Granzyme B Induces Smooth Muscle Cell Apoptosis in the Absence of Perforin: Involvement of Extracellular Matrix Degradation

OBJECTIVE—T cell-induced cytotoxicity, of which granzyme B is a key mediator, is believed to contribute to the pathogenesis of inflammatory vascular diseases. In this report, we investigate the mechanism of granzyme B-induced smooth muscle cell (SMC) death. METHODS AND RESULTS—The addition of purifi...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2004-12, Vol.24 (12), p.2245-2250
Hauptverfasser:	Choy, Jonathan C, Hung, Vivian H.Y, Hunter, Arwen L, Cheung, Paul K, Motyka, Bruce, Goping, Ing Swie, Sawchuk, Tracy, Bleackley, R Chris, Podor, Thomas J, McManus, Bruce M, Granville, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Caspase 3 Caspases - metabolism Cell Line, Tumor Cell Survival - physiology Coronary Vessels - enzymology Coronary Vessels - metabolism Extracellular Matrix - enzymology Extracellular Matrix - metabolism Extracellular Matrix Proteins - metabolism Granzymes HeLa Cells - chemistry HeLa Cells - metabolism Humans Membrane Glycoproteins - deficiency Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - physiology Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - physiology Perforin Pore Forming Cytotoxic Proteins Rats Serine Endopeptidases - metabolism Serine Endopeptidases - physiology Spleen - cytology Spleen - metabolism
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