High-throughput multiplexed capillary electrophoresis in drug discovery
The demand for high-throughput analytical tools to support drug discovery applications has led to the development of multiplexed capillary electrophoresis and multichannel microfluidic devices to characterize libraries of compounds and alleviate backlogs in the discovery process. The capability to a...
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| Veröffentlicht in: | Drug Discovery Today 2004-12, Vol.9 (24), p.1072-1080 |
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| creator | Pang, Ho-ming Kenseth, Jeremy Coldiron, Shelley |
| description | The demand for high-throughput analytical tools to support drug discovery applications has led to the development of multiplexed capillary electrophoresis and multichannel microfluidic devices to characterize libraries of compounds and alleviate backlogs in the discovery process. The capability to analyze multiple samples in parallel, and the diverse separation conditions that are permissible, facilitates rapid turnaround times. Examples of high-throughput applications of multiplexed electrophoresis in drug discovery include: physicochemical profiling, enzyme analysis, chiral separations and protein/metabolite analysis. Many single capillary electrophoresis methods can be potentially adapted to a multiplexed format, therefore, we anticipate the development of other high-throughput applications in the near future, which should facilitate decreases in sample analysis time and help improve laboratory efficiency.
This review focuses on recent developments relating to multiplexed capillary electrophoresis and multichannel microfluidic electrophoresis devices for performing high throughput drug discovery and development applications. |
| doi_str_mv | 10.1016/S1359-6446(04)03293-3 |
| format | Article |
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This review focuses on recent developments relating to multiplexed capillary electrophoresis and multichannel microfluidic electrophoresis devices for performing high throughput drug discovery and development applications.</description><subject>Biological and medical sciences</subject><subject>chiral separations</subject><subject>Drug Design</subject><subject>drug profiling</subject><subject>Electrophoresis, Capillary - instrumentation</subject><subject>Electrophoresis, Capillary - methods</subject><subject>enzyme analysis</subject><subject>General pharmacology</subject><subject>high throughput drug discovery application</subject><subject>Medical sciences</subject><subject>Microfluidic Analytical Techniques - instrumentation</subject><subject>Microfluidic Analytical Techniques - methods</subject><subject>multiplexed capillary electrophoresis</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. 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| ispartof | Drug Discovery Today, 2004-12, Vol.9 (24), p.1072-1080 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences chiral separations Drug Design drug profiling Electrophoresis, Capillary - instrumentation Electrophoresis, Capillary - methods enzyme analysis General pharmacology high throughput drug discovery application Medical sciences Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - methods multiplexed capillary electrophoresis Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments physicochemical profiling protein analysis Technology, Pharmaceutical - methods Technology, Pharmaceutical - trends |
| title | High-throughput multiplexed capillary electrophoresis in drug discovery |
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