Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription

We previously reported prolonged HIV-1 transcriptional gene silencing by an RNA duplex targeting a sequence located within the NF-κB binding motif of the HIV-1 promoter in a susceptible HeLa cell line. Here we report extremely prolonged suppression of productive HIV-1 infection in a T-cell line (Mol...

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Veröffentlicht in:	Microbes and infection 2009-04, Vol.11 (4), p.500-508
Hauptverfasser:	Yamagishi, Makoto, Ishida, Takaomi, Miyake, Ariko, Cooper, David A., Kelleher, Anthony D., Suzuki, Kazuo, Watanabe, Toshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Base Sequence Biological and medical sciences CD4-Positive T-Lymphocytes - virology Fundamental and applied biological sciences. Psychology Gene Silencing HeLa Cells HIV-1 HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus 1 Humans Microbiology Miscellaneous Molecular Sequence Data Retroviridae - genetics RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA, Small Interfering - pharmacology RNA, Viral - genetics RNA, Viral - metabolism shRNA Transcription, Genetic Transcriptional gene silencing Transduction, Genetic Virology Virus Replication
Online-Zugang:	Volltext
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