Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry
Living cells rival computers in their ability to process external information and make complex behavioral decisions. Many of these decisions are made by networks of interacting signaling proteins. Ongoing structural, biochemical and cell-based studies have begun to reveal several common principles b...
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| Veröffentlicht in: | Current opinion in structural biology 2004-12, Vol.14 (6), p.690-699 |
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| container_title | Current opinion in structural biology |
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| creator | Dueber, John E Yeh, Brian J Bhattacharyya, Roby P Lim, Wendell A |
| description | Living cells rival computers in their ability to process external information and make complex behavioral decisions. Many of these decisions are made by networks of interacting signaling proteins. Ongoing structural, biochemical and cell-based studies have begun to reveal several common principles by which protein components are used to specifically transmit and process information. Recent engineering studies demonstrate that these relatively simple principles can be used to rewire signaling behavior in a process that mimics the evolution of new phenotypic responses. |
| doi_str_mv | 10.1016/j.sbi.2004.10.004 |
| format | Article |
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| ispartof | Current opinion in structural biology, 2004-12, Vol.14 (6), p.690-699 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptation, Physiological - physiology Animals Binding Sites Eukaryotic Cells - chemistry Eukaryotic Cells - metabolism Evolution, Molecular Gene Expression Regulation - physiology Humans Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - metabolism Models, Biological Models, Chemical Models, Molecular Protein Binding Protein Engineering - methods Signal Transduction - physiology Structure-Activity Relationship |
| title | Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry |
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