Replicon Dynamics, Dormant Origin Firing, and Terminal Fork Integrity after Double-Strand Break Formation

In response to replication stress, the Mec1/ATR and SUMO pathways control stalled- and damaged-fork stability. We investigated the S phase response at forks encountering a broken template (termed the terminal fork). We show that double-strand break (DSB) formation can locally trigger dormant origin...

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Veröffentlicht in:	Cell 2009-04, Vol.137 (2), p.247-258
Hauptverfasser:	Doksani, Ylli, Bermejo, Rodrigo, Fiorani, Simona, Haber, James E., Foiani, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	CELLCYCLE DNA DNA Repair DNA Replication Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Endonucleases Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Replication Origin Replicon Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism
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