A model of a transmembrane drug-efflux pump from Gram-negative bacteria

In Gram-negative bacteria, drug resistance is due in part to the activity of transmembrane efflux-pumps, which are composed of three types of proteins. A representative pump from Escherichia coli is an assembly of the trimeric outer-membrane protein TolC, which is an allosteric channel, the trimeric...

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Veröffentlicht in:	FEBS letters 2004-12, Vol.578 (1), p.5-9
Hauptverfasser:	Fernandez-Recio, Juan, Walas, Fabien, Federici, Luca, Venkatesh Pratap, J., Bavro, Vassiliy N., Miguel, Ricardo Nunez, Mizuguchi, Kenji, Luisi, Ben
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - metabolism Carrier Proteins - chemistry Carrier Proteins - metabolism Drug Resistance, Microbial Escherichia coli Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Gram-Negative Bacteria - physiology Homology modelling inner-membrane major facilitator superfamily membrane fusion protein Membrane Proteins - chemistry Membrane Proteins - metabolism Membrane Transport Proteins - chemistry Membrane Transport Proteins - metabolism MFP MFS Models, Biological Models, Molecular Molecular docking and allostery Multidrug resistance Multidrug Resistance-Associated Proteins outer-membrane Protein Conformation Pseudomonas aeruginosa Pump-channel resistance-nodulation-division RND Transmembrane transport
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