The effect of topoisomerase II inhibitors on the kinetoplast ultrastructure

Topoisomerases from trypanosomatids play key functions in the replication and organization of kinetoplast DNA (kDNA). Hence, they are considered as potential targets for anti-parasite drugs. In this paper, the effect of topoisomerase II inhibitors, such as nalidixic acid, novobiocin and etoposide, o...

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Veröffentlicht in:	Parasitology research (1987) 2004-12, Vol.94 (6), p.439-448
Hauptverfasser:	CAVALCANTI, Danielle P, FRAGOSO, Stenio P, GOLDENBERG, Samuel, DE SOUZA, Wanderley, MOTTA, Maria Cristina M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences DNA Replication DNA Topoisomerases, Type II - metabolism DNA, Kinetoplast - metabolism DNA, Kinetoplast - ultrastructure Enzyme Inhibitors - pharmacology Etoposide - pharmacology Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Invertebrates Nalidixic Acid - pharmacology Novobiocin - pharmacology Parasitic Sensitivity Tests Topoisomerase II Inhibitors Trypanocidal Agents - pharmacology Trypanosomatina - drug effects Trypanosomatina - enzymology Trypanosomatina - genetics Trypanosomatina - growth & development
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