Searching for new allosteric sites in enzymes

The discovery of new allosteric sites generates opportunities for the identification of novel pharmaceuticals and increases our understanding of basic biological processes. Increasingly, allosteric sites are being discovered in various families of proteins by several methods, paving the way for the...

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Veröffentlicht in:	Current opinion in structural biology 2004-12, Vol.14 (6), p.706-715
Hauptverfasser:	Hardy, Jeanne A, Wells, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site - physiology Animals Binding Sites Catalysis Enzyme Activation Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzymes - chemistry Enzymes - metabolism Homeostasis - physiology Humans Models, Biological Models, Chemical Models, Molecular Protein Binding Protein Conformation Sequence Analysis, Protein - methods Structure-Activity Relationship
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