Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells

Regulator of G protein signalling (RGS) protein expression is altered under growth promoting conditions in vascular smooth muscle cells (VSMCs). Since sphingosine-1-phosphate (S1P) is an important growth stimulatory factor, we investigated whether stimulation of VSMCs with S1P results in alterations...

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Veröffentlicht in:	European journal of pharmacology 2009-03, Vol.606 (1), p.25-31
Hauptverfasser:	Hendriks-Balk, Mariëlle C., Hajji, Najat, van Loenen, Pieter B., Michel, Martin C., Peters, Stephan L.M., Alewijnse, Astrid E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences FTY720-P Gene Expression Regulation - drug effects Lysophospholipids - metabolism Lysophospholipids - pharmacology Male Medical sciences Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Receptors, Lysosphingolipid - metabolism Regulator of G protein signalling RGS Proteins - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine - pharmacology Sphingosine-1-phosphate receptor Up-Regulation - drug effects VSMC
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