Malignant transformation of sialadenoma papilliferum of the palate: a case report
We report a case of a 79-year-old woman with an unusual salivary gland tumor that developed at the junction between the soft and hard palates. The tumor consisted of sialadenoma papilliferum (SP) with areas of an epithelial-myoepithelial carcinoma (EMC) component and a high-grade carcinoma component...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2004-12, Vol.445 (6), p.641-646 |
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| container_title | Virchows Archiv : an international journal of pathology |
| container_volume | 445 |
| creator | SHIMODA, Masayuki KAMEYAMA, Kaori MORINAGA, Shojiroh TANAKA, Youichi HASHIGUCHI, Kazuhiro SHIMADA, Megumi OKADA, Yasunori |
| description | We report a case of a 79-year-old woman with an unusual salivary gland tumor that developed at the junction between the soft and hard palates. The tumor consisted of sialadenoma papilliferum (SP) with areas of an epithelial-myoepithelial carcinoma (EMC) component and a high-grade carcinoma component. There were also transitional regions among the SP, the EMC and the high-grade carcinoma components. The high-grade carcinoma component, which was similar to invasive micropapillary carcinoma of the breast, infiltrated into the right parapharyngeal space and metastasized to the lungs and cervical vertebrae. The high-grade carcinoma cells were positively immunostained for p53 protein. SP has been considered to be a benign tumor with exceptionally good prognosis, and, to the best of our knowledge, there has never been a confirmed case of malignant SP. This is the first report of SP with a definite malignant component. |
| doi_str_mv | 10.1007/s00428-004-1091-4 |
| format | Article |
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The tumor consisted of sialadenoma papilliferum (SP) with areas of an epithelial-myoepithelial carcinoma (EMC) component and a high-grade carcinoma component. There were also transitional regions among the SP, the EMC and the high-grade carcinoma components. The high-grade carcinoma component, which was similar to invasive micropapillary carcinoma of the breast, infiltrated into the right parapharyngeal space and metastasized to the lungs and cervical vertebrae. The high-grade carcinoma cells were positively immunostained for p53 protein. SP has been considered to be a benign tumor with exceptionally good prognosis, and, to the best of our knowledge, there has never been a confirmed case of malignant SP. This is the first report of SP with a definite malignant component.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-004-1091-4</identifier><identifier>PMID: 15455228</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Aged ; Biological and medical sciences ; Cell Transformation, Neoplastic ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Palatal Neoplasms - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. 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The tumor consisted of sialadenoma papilliferum (SP) with areas of an epithelial-myoepithelial carcinoma (EMC) component and a high-grade carcinoma component. There were also transitional regions among the SP, the EMC and the high-grade carcinoma components. The high-grade carcinoma component, which was similar to invasive micropapillary carcinoma of the breast, infiltrated into the right parapharyngeal space and metastasized to the lungs and cervical vertebrae. The high-grade carcinoma cells were positively immunostained for p53 protein. SP has been considered to be a benign tumor with exceptionally good prognosis, and, to the best of our knowledge, there has never been a confirmed case of malignant SP. 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| ispartof | Virchows Archiv : an international journal of pathology, 2004-12, Vol.445 (6), p.641-646 |
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| source | MEDLINE; SpringerNature Complete Journals |
| subjects | Aged Biological and medical sciences Cell Transformation, Neoplastic Female Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Palatal Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Salivary Gland Neoplasms - pathology Tumor Suppressor Protein p53 - analysis |
| title | Malignant transformation of sialadenoma papilliferum of the palate: a case report |
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