The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid

Because monocyte chemotactic protein (MCP)-1 is an important cofactor in HIV neuropathogenesis, we investigated the relationship between MCP-1 genotype and expression in cerebrospinal fluid (CSF). We evaluated a genetic polymorphism in the MCP-1 promoter at position -2578 (alternatively designated -...

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Veröffentlicht in:	Journal of neuroimmunology 2004-12, Vol.157 (1), p.193-196
Hauptverfasser:	Letendre, Scott, Marquie-Beck, Jennifer, Singh, Kumud K., de Almeida, Sergio, Zimmerman, Joshua, A. Spector, Stephen, Grant, Igor, Ellis, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS Alleles Cerebrospinal fluid Chemokine Chemokine CCL2 - blood Chemokine CCL2 - cerebrospinal fluid Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Demography Female Genotype HIV HIV Infections - blood HIV Infections - cerebrospinal fluid Human immunodeficiency virus Humans Male MCP-1 Monocytes - metabolism Polymorphism, Single Nucleotide - genetics Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis
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