The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells

Calcium ion is one of the most important second messengers of cellular signal transduction including hypoxia-elicited signals. In this study, we investigated the effects of the L-type calcium channel blockers such as nifedipine, efonidipine cilnidipine, diltiazem, and verapamil, on the activity of h...

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Veröffentlicht in:	European journal of pharmacology 2009-03, Vol.606 (1), p.130-136
Hauptverfasser:	Oda, Seiko, Oda, Tomoyuki, Takabuchi, Satoshi, Nishi, Kenichiro, Wakamatsu, Takuhiko, Tanaka, Tomoharu, Adachi, Takehiko, Fukuda, Kazuhiko, Nohara, Ryuji, Hirota, Kiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium - metabolism Calcium channel blocker Calcium Channel Blockers - pharmacology Cell Line, Tumor Dihydropyridines - pharmacology Gene Expression Regulation - drug effects Humans Hypoxia Hypoxia-inducible factor 1 (HIF-1) Hypoxia-Inducible Factor 1 - antagonists & inhibitors Hypoxia-Inducible Factor 1 - metabolism Intracellular Space - drug effects Intracellular Space - metabolism Medical sciences Oxygen - metabolism Pharmacology. Drug treatments Smooth muscle cell Stress, Physiological - drug effects Translation Vascular endothelial cell
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