Correlation of Clinical Features With the Mutational Status of GM-CSF Signaling Pathway-Related Genes in Juvenile Myelomonocytic Leukemia

Mutations in RAS , neurofibromatosis type 1 ( NF1 ), and PTPN11 , constituents of the granulocyte-macrophage colony-stimulating factor signaling pathway, have been recognized in patients with juvenile myelomonocytic leukemia (JMML). We assessed 71 children with JMML for NRAS , KRAS , and PTPN11 muta...

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Veröffentlicht in:	Pediatric research 2009-03, Vol.65 (3), p.334-340
Hauptverfasser:	Yoshida, Nao, Yagasaki, Hiroshi, Xu, Yinyan, Matsuda, Kazuyuki, Yoshimi, Ayami, Takahashi, Yoshiyuki, Hama, Asahito, Nishio, Nobuhiro, Muramatsu, Hideki, Watanabe, Nobuhiro, Matsumoto, Kimikazu, Kato, Koji, Ueyama, Junichi, Inada, Hiroko, Goto, Hiroaki, Yabe, Miharu, Kudo, Kazuko, Mimaya, Junichi, Kikuchi, Akira, Manabe, Atsushi, Koike, Kenichi, Kojima, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Child Child, Preschool DNA Mutational Analysis General aspects Genetic Testing Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Hematopoietic Stem Cell Transplantation Humans Infant Japan Leukemia, Myelomonocytic, Juvenile - genetics Leukemia, Myelomonocytic, Juvenile - therapy Medical sciences Medicine Medicine & Public Health Neurofibromin 1 - genetics Pediatric Surgery Pediatrics Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics ras Proteins - genetics Signal Transduction - genetics Survival Analysis translational-investigation
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