Osteosarcoma and Ewing's sarcoma in children and adolescents: retrospective clinicopathological study
Almost 20 different prognostic factors have so far been investigated in childhood bone tumors, but apart from clinical stage the results have been inconclusive. We evaluated possible prognostic factors of malignant bone tumors in children and adolescents. Seventy children and adolescents, who have b...
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| Veröffentlicht in: | Croatian medical journal 2004-12, Vol.45 (6), p.740-745 |
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| creator | Ilić, Ivana Manojlović, Spomenka Cepulić, Mladen Orlić, Dubravko Seiwerth, Sven |
| description | Almost 20 different prognostic factors have so far been investigated in childhood bone tumors, but apart from clinical stage the results have been inconclusive. We evaluated possible prognostic factors of malignant bone tumors in children and adolescents.
Seventy children and adolescents, who have been treated for bone sarcomas (36 with osteosarcoma and 34 with Ewing's sarcoma) at the Children's Hospital in Zagreb and the Orthopedic Clinic of the Zagreb University School of Medicine were included in the study. We analyzed 9 variables: clinical stage, patient age and sex, tumor size and location, location of metastases, chemotherapy response, concentration of lactate dehydrogenase (LDH) and erythrocyte sedimentation rate (ESR), and chondroid differentiation in osteosarcoma.
The clinical stage was the most important prognostic factor for both type of tumors. Lactate dehydrogenase in patients with Ewing's sarcoma (p=0.033) and in patients with osteosarcoma (p=0.015) as well as erythrocyte sedimentation rate (p |
| format | Article |
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Seventy children and adolescents, who have been treated for bone sarcomas (36 with osteosarcoma and 34 with Ewing's sarcoma) at the Children's Hospital in Zagreb and the Orthopedic Clinic of the Zagreb University School of Medicine were included in the study. We analyzed 9 variables: clinical stage, patient age and sex, tumor size and location, location of metastases, chemotherapy response, concentration of lactate dehydrogenase (LDH) and erythrocyte sedimentation rate (ESR), and chondroid differentiation in osteosarcoma.
The clinical stage was the most important prognostic factor for both type of tumors. Lactate dehydrogenase in patients with Ewing's sarcoma (p=0.033) and in patients with osteosarcoma (p=0.015) as well as erythrocyte sedimentation rate (p<0.001 and p=0.014, respectively) may also be of predictive value.
Elevated erythrocyte sedimentation rate and high LDH concentration seem to be of importance in both Ewing's sarcoma and osteosarcoma, regardless of their different pathogenesis or pathohistology.</description><identifier>ISSN: 0353-9504</identifier><identifier>PMID: 15578809</identifier><language>eng</language><publisher>Croatia</publisher><subject>Adolescent ; Bone Neoplasms - diagnosis ; Bone Neoplasms - mortality ; Bone Neoplasms - therapy ; Child ; Child, Preschool ; Croatia - epidemiology ; Female ; Humans ; Infant ; Male ; Osteosarcoma - diagnosis ; Osteosarcoma - mortality ; Osteosarcoma - therapy ; Prognosis ; Retrospective Studies ; Sarcoma, Ewing - diagnosis ; Sarcoma, Ewing - mortality ; Sarcoma, Ewing - therapy ; Survival Rate</subject><ispartof>Croatian medical journal, 2004-12, Vol.45 (6), p.740-745</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15578809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ilić, Ivana</creatorcontrib><creatorcontrib>Manojlović, Spomenka</creatorcontrib><creatorcontrib>Cepulić, Mladen</creatorcontrib><creatorcontrib>Orlić, Dubravko</creatorcontrib><creatorcontrib>Seiwerth, Sven</creatorcontrib><title>Osteosarcoma and Ewing's sarcoma in children and adolescents: retrospective clinicopathological study</title><title>Croatian medical journal</title><addtitle>Croat Med J</addtitle><description>Almost 20 different prognostic factors have so far been investigated in childhood bone tumors, but apart from clinical stage the results have been inconclusive. We evaluated possible prognostic factors of malignant bone tumors in children and adolescents.
Seventy children and adolescents, who have been treated for bone sarcomas (36 with osteosarcoma and 34 with Ewing's sarcoma) at the Children's Hospital in Zagreb and the Orthopedic Clinic of the Zagreb University School of Medicine were included in the study. We analyzed 9 variables: clinical stage, patient age and sex, tumor size and location, location of metastases, chemotherapy response, concentration of lactate dehydrogenase (LDH) and erythrocyte sedimentation rate (ESR), and chondroid differentiation in osteosarcoma.
The clinical stage was the most important prognostic factor for both type of tumors. Lactate dehydrogenase in patients with Ewing's sarcoma (p=0.033) and in patients with osteosarcoma (p=0.015) as well as erythrocyte sedimentation rate (p<0.001 and p=0.014, respectively) may also be of predictive value.
Elevated erythrocyte sedimentation rate and high LDH concentration seem to be of importance in both Ewing's sarcoma and osteosarcoma, regardless of their different pathogenesis or pathohistology.</description><subject>Adolescent</subject><subject>Bone Neoplasms - diagnosis</subject><subject>Bone Neoplasms - mortality</subject><subject>Bone Neoplasms - therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Croatia - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Osteosarcoma - diagnosis</subject><subject>Osteosarcoma - mortality</subject><subject>Osteosarcoma - therapy</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sarcoma, Ewing - diagnosis</subject><subject>Sarcoma, Ewing - mortality</subject><subject>Sarcoma, Ewing - therapy</subject><subject>Survival Rate</subject><issn>0353-9504</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLAzEcxHNQbK1-BclJTwvZzWMbb1LqAwq96HnJ479tJJusSVbpt7doexqY-TEMc4HmhHJaSU7YDF3n_ElIQxgTV2hWc94ul0TOEWxzgZhVMnFQWAWL1z8u7B4yPnsuYLN33iYIf7my0UM2EEp-xAlKinkEU9w3YONdcCaOquyjjztnlMe5TPZwgy575TPcnnSBPp7X76vXarN9eVs9baqxIbJUlBuuKQhpQGvDj3NFDS2RmlmpBFN1rTldNtIKznsA3ROhqNDMkJ4aVQu6QPf_vWOKXxPk0g3uONV7FSBOuRNtzVohmiN4dwInPYDtxuQGlQ7d-Rj6C3RCYJ4</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Ilić, Ivana</creator><creator>Manojlović, Spomenka</creator><creator>Cepulić, Mladen</creator><creator>Orlić, Dubravko</creator><creator>Seiwerth, Sven</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200412</creationdate><title>Osteosarcoma and Ewing's sarcoma in children and adolescents: retrospective clinicopathological study</title><author>Ilić, Ivana ; Manojlović, Spomenka ; Cepulić, Mladen ; Orlić, Dubravko ; Seiwerth, Sven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-35c5b3e69cebbc502061e709b4d9a64a11b53829d655feebf06a36b4c0f3ca163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Bone Neoplasms - diagnosis</topic><topic>Bone Neoplasms - mortality</topic><topic>Bone Neoplasms - therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Croatia - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Osteosarcoma - diagnosis</topic><topic>Osteosarcoma - mortality</topic><topic>Osteosarcoma - therapy</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sarcoma, Ewing - diagnosis</topic><topic>Sarcoma, Ewing - mortality</topic><topic>Sarcoma, Ewing - therapy</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ilić, Ivana</creatorcontrib><creatorcontrib>Manojlović, Spomenka</creatorcontrib><creatorcontrib>Cepulić, Mladen</creatorcontrib><creatorcontrib>Orlić, Dubravko</creatorcontrib><creatorcontrib>Seiwerth, Sven</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Croatian medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ilić, Ivana</au><au>Manojlović, Spomenka</au><au>Cepulić, Mladen</au><au>Orlić, Dubravko</au><au>Seiwerth, Sven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteosarcoma and Ewing's sarcoma in children and adolescents: retrospective clinicopathological study</atitle><jtitle>Croatian medical journal</jtitle><addtitle>Croat Med J</addtitle><date>2004-12</date><risdate>2004</risdate><volume>45</volume><issue>6</issue><spage>740</spage><epage>745</epage><pages>740-745</pages><issn>0353-9504</issn><abstract>Almost 20 different prognostic factors have so far been investigated in childhood bone tumors, but apart from clinical stage the results have been inconclusive. We evaluated possible prognostic factors of malignant bone tumors in children and adolescents.
Seventy children and adolescents, who have been treated for bone sarcomas (36 with osteosarcoma and 34 with Ewing's sarcoma) at the Children's Hospital in Zagreb and the Orthopedic Clinic of the Zagreb University School of Medicine were included in the study. We analyzed 9 variables: clinical stage, patient age and sex, tumor size and location, location of metastases, chemotherapy response, concentration of lactate dehydrogenase (LDH) and erythrocyte sedimentation rate (ESR), and chondroid differentiation in osteosarcoma.
The clinical stage was the most important prognostic factor for both type of tumors. Lactate dehydrogenase in patients with Ewing's sarcoma (p=0.033) and in patients with osteosarcoma (p=0.015) as well as erythrocyte sedimentation rate (p<0.001 and p=0.014, respectively) may also be of predictive value.
Elevated erythrocyte sedimentation rate and high LDH concentration seem to be of importance in both Ewing's sarcoma and osteosarcoma, regardless of their different pathogenesis or pathohistology.</abstract><cop>Croatia</cop><pmid>15578809</pmid><tpages>6</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Bone Neoplasms - diagnosis Bone Neoplasms - mortality Bone Neoplasms - therapy Child Child, Preschool Croatia - epidemiology Female Humans Infant Male Osteosarcoma - diagnosis Osteosarcoma - mortality Osteosarcoma - therapy Prognosis Retrospective Studies Sarcoma, Ewing - diagnosis Sarcoma, Ewing - mortality Sarcoma, Ewing - therapy Survival Rate |
| title | Osteosarcoma and Ewing's sarcoma in children and adolescents: retrospective clinicopathological study |
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