Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry
The sensitivity of a large number of antibiotic-resistant and nonresistant Helicobacter pylori isolates to the antiadhesion effect of a high-molecular-mass, nondialysable constituent of cranberry juice was tested. Confluent monolayers of gastric cell line in microtiter plate wells were exposed to ba...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 2004-12, Vol.50 (4), p.231-235 |
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| container_title | Diagnostic microbiology and infectious disease |
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| creator | Shmuely, Haim Burger, Ora Neeman, Itzhak Yahav, Jacob Samra, Zmira Niv, Yaron Sharon, Nathan Weiss, Erwin Athamna, Abed Tabak, Miriam Ofek, Itzhak |
| description | The sensitivity of a large number of antibiotic-resistant and nonresistant
Helicobacter pylori isolates to the antiadhesion effect of a high-molecular-mass, nondialysable constituent of cranberry juice was tested. Confluent monolayers of gastric cell line in microtiter plate wells were exposed to bacterial suspensions prepared from 83
H. pylori isolates from antibiotic-treated and untreated patients in the presence and absence of the cranberry constituent. Urease assay was used to calculate the percentage of adhesion inhibition. In two thirds of the isolates, adhesion to the gastric cells was inhibited by 0.2 mg/mL of the nondialysable material. There was no relationship between the antiadhesion effect of the cranberry material and metronidazole resistance in isolates from either treated or untreated patients (N = 35). Only 13 isolates (16%) were resistant to both the nondialysable material and metronidazole, and 30 (36%) were resistant to the nondialysable material alone. There was no cross-resistance to the nondialysable material and metronidazole. These data suggest that a combination of antibiotics and a cranberry preparation may improve
H. pylori eradication. |
| doi_str_mv | 10.1016/j.diagmicrobio.2004.08.011 |
| format | Article |
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Helicobacter pylori isolates to the antiadhesion effect of a high-molecular-mass, nondialysable constituent of cranberry juice was tested. Confluent monolayers of gastric cell line in microtiter plate wells were exposed to bacterial suspensions prepared from 83
H. pylori isolates from antibiotic-treated and untreated patients in the presence and absence of the cranberry constituent. Urease assay was used to calculate the percentage of adhesion inhibition. In two thirds of the isolates, adhesion to the gastric cells was inhibited by 0.2 mg/mL of the nondialysable material. There was no relationship between the antiadhesion effect of the cranberry material and metronidazole resistance in isolates from either treated or untreated patients (N = 35). Only 13 isolates (16%) were resistant to both the nondialysable material and metronidazole, and 30 (36%) were resistant to the nondialysable material alone. There was no cross-resistance to the nondialysable material and metronidazole. These data suggest that a combination of antibiotics and a cranberry preparation may improve
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Helicobacter pylori isolates to the antiadhesion effect of a high-molecular-mass, nondialysable constituent of cranberry juice was tested. Confluent monolayers of gastric cell line in microtiter plate wells were exposed to bacterial suspensions prepared from 83
H. pylori isolates from antibiotic-treated and untreated patients in the presence and absence of the cranberry constituent. Urease assay was used to calculate the percentage of adhesion inhibition. In two thirds of the isolates, adhesion to the gastric cells was inhibited by 0.2 mg/mL of the nondialysable material. There was no relationship between the antiadhesion effect of the cranberry material and metronidazole resistance in isolates from either treated or untreated patients (N = 35). Only 13 isolates (16%) were resistant to both the nondialysable material and metronidazole, and 30 (36%) were resistant to the nondialysable material alone. There was no cross-resistance to the nondialysable material and metronidazole. These data suggest that a combination of antibiotics and a cranberry preparation may improve
H. pylori eradication.</description><subject>Amoxicillin - pharmacology</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Adhesion - drug effects</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Dialysis</subject><subject>Drug Resistance, Bacterial</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - drug effects</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Weight</topic><topic>Penicillin Resistance</topic><topic>Stomach - cytology</topic><topic>Vaccinium macrocarpon - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shmuely, Haim</creatorcontrib><creatorcontrib>Burger, Ora</creatorcontrib><creatorcontrib>Neeman, Itzhak</creatorcontrib><creatorcontrib>Yahav, Jacob</creatorcontrib><creatorcontrib>Samra, Zmira</creatorcontrib><creatorcontrib>Niv, Yaron</creatorcontrib><creatorcontrib>Sharon, Nathan</creatorcontrib><creatorcontrib>Weiss, Erwin</creatorcontrib><creatorcontrib>Athamna, Abed</creatorcontrib><creatorcontrib>Tabak, Miriam</creatorcontrib><creatorcontrib>Ofek, Itzhak</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shmuely, Haim</au><au>Burger, Ora</au><au>Neeman, Itzhak</au><au>Yahav, Jacob</au><au>Samra, Zmira</au><au>Niv, Yaron</au><au>Sharon, Nathan</au><au>Weiss, Erwin</au><au>Athamna, Abed</au><au>Tabak, Miriam</au><au>Ofek, Itzhak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>50</volume><issue>4</issue><spage>231</spage><epage>235</epage><pages>231-235</pages><issn>0732-8893</issn><eissn>1879-0070</eissn><coden>DMIDDZ</coden><abstract>The sensitivity of a large number of antibiotic-resistant and nonresistant
Helicobacter pylori isolates to the antiadhesion effect of a high-molecular-mass, nondialysable constituent of cranberry juice was tested. Confluent monolayers of gastric cell line in microtiter plate wells were exposed to bacterial suspensions prepared from 83
H. pylori isolates from antibiotic-treated and untreated patients in the presence and absence of the cranberry constituent. Urease assay was used to calculate the percentage of adhesion inhibition. In two thirds of the isolates, adhesion to the gastric cells was inhibited by 0.2 mg/mL of the nondialysable material. There was no relationship between the antiadhesion effect of the cranberry material and metronidazole resistance in isolates from either treated or untreated patients (N = 35). Only 13 isolates (16%) were resistant to both the nondialysable material and metronidazole, and 30 (36%) were resistant to the nondialysable material alone. There was no cross-resistance to the nondialysable material and metronidazole. These data suggest that a combination of antibiotics and a cranberry preparation may improve
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| ispartof | Diagnostic microbiology and infectious disease, 2004-12, Vol.50 (4), p.231-235 |
| issn | 0732-8893 1879-0070 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amoxicillin - pharmacology Anti-Bacterial Agents - pharmacology Bacterial Adhesion - drug effects Bacteriology Biological and medical sciences Cell Line, Tumor Dialysis Drug Resistance, Bacterial Fundamental and applied biological sciences. Psychology Helicobacter pylori Helicobacter pylori - drug effects Humans Infectious diseases Medical sciences Microbiology Miscellaneous Molecular Weight Penicillin Resistance Stomach - cytology Vaccinium macrocarpon - chemistry |
| title | Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry |
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