Familial Aggregation of Melanoma Risks in a Large Population-Based Sample of Melanoma Cases
Objective: Melanoma has been shown in numerous studies to be associated with sun exposure, and with host phenotypic factors of genetic origin. In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of in...
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| Veröffentlicht in: | Cancer causes & control 2004-11, Vol.15 (9), p.957-965 |
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| creator | Begg, Colin B. Hummer, Amanda Mujumdar, Urvi Armstrong, Bruce K. Kricker, Anne Marrett, Loraine D. Millikan, Robert C. Gruber, Stephen B. Anton-Culver, Hoda Klotz, Judith B. Zanetti, Roberto Gallagher, Richard P. Dwyer, Terence Rebbeck, Timothy R. Berwick, Marianne |
| description | Objective: Melanoma has been shown in numerous studies to be associated with sun exposure, and with host phenotypic factors of genetic origin. In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of incidence of melanoma in the first-degree relatives of these cases. Methods: A total of 2508 incident cases of melanoma provided information on basic demographic data and pigmentary characteristics, in addition to detailed information on family history of melanoma. These data were used to examine the incidence rates ratios of melanoma in the relatives of cases in relation to population rates, and also with respect to phenotypic characteristics of the probands that have been shown to be associated with melanoma: mole counts, hair color, eye color, and skin sensitivity to the sun. Results: The incidence rates reflect the underlying patterns of incidence in the source populations, with generally higher rates in the Australian sample, low rates in Italy, and intermediate rates in the USA and Canada. Also, rates are higher in men than in women, except at very young ages. Phenotypic characteristics of the probands were only weakly associated with the observed rates in the relatives although there is a strong inverse association with age at diagnosis. Cumulative risk of melanoma rises to 6.9% (6.1%) at age 80 in male (female) first-degree relatives of cases, and to 10.8% (9.5%) in relatives of cases diagnosed before age 50. Conclusions: Relatives of cases diagnosed with melanoma are at considerable lifetime risk of the disease, especially if the case is diagnosed at a young age. |
| doi_str_mv | 10.1007/s10552-004-2474-1 |
| format | Article |
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In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of incidence of melanoma in the first-degree relatives of these cases. Methods: A total of 2508 incident cases of melanoma provided information on basic demographic data and pigmentary characteristics, in addition to detailed information on family history of melanoma. These data were used to examine the incidence rates ratios of melanoma in the relatives of cases in relation to population rates, and also with respect to phenotypic characteristics of the probands that have been shown to be associated with melanoma: mole counts, hair color, eye color, and skin sensitivity to the sun. Results: The incidence rates reflect the underlying patterns of incidence in the source populations, with generally higher rates in the Australian sample, low rates in Italy, and intermediate rates in the USA and Canada. Also, rates are higher in men than in women, except at very young ages. Phenotypic characteristics of the probands were only weakly associated with the observed rates in the relatives although there is a strong inverse association with age at diagnosis. Cumulative risk of melanoma rises to 6.9% (6.1%) at age 80 in male (female) first-degree relatives of cases, and to 10.8% (9.5%) in relatives of cases diagnosed before age 50. Conclusions: Relatives of cases diagnosed with melanoma are at considerable lifetime risk of the disease, especially if the case is diagnosed at a young age.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-004-2474-1</identifier><identifier>PMID: 15577298</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Netherlands: Kluwer Academic Publishers</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Aggregation ; Australia - epidemiology ; Cancer ; Cohort Studies ; Disease prevention ; Disease risk ; Epidemiology ; Family Health ; Family history ; Family medical history ; Female ; Genetic Predisposition to Disease - epidemiology ; Genetic Predisposition to Disease - genetics ; Hair ; Humans ; Incidence ; Male ; Medical genetics ; Melanoma ; Melanoma - epidemiology ; Melanoma - genetics ; Middle Aged ; Nevus ; North America - epidemiology ; Phenotype ; Population ; Predisposing factors ; Questionnaires ; Risk factors ; Sex Distribution</subject><ispartof>Cancer causes & control, 2004-11, Vol.15 (9), p.957-965</ispartof><rights>Copyright 2004 Kluwer Academic Publishers</rights><rights>Copyright (c) 2004 Kluwer Academic Publishers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-f8981c535d1f18851140bae24671e567e18d7d70f295c850d13fc47c055b89823</citedby><cites>FETCH-LOGICAL-c390t-f8981c535d1f18851140bae24671e567e18d7d70f295c850d13fc47c055b89823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3553605$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3553605$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15577298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Begg, Colin B.</creatorcontrib><creatorcontrib>Hummer, Amanda</creatorcontrib><creatorcontrib>Mujumdar, Urvi</creatorcontrib><creatorcontrib>Armstrong, Bruce K.</creatorcontrib><creatorcontrib>Kricker, Anne</creatorcontrib><creatorcontrib>Marrett, Loraine D.</creatorcontrib><creatorcontrib>Millikan, Robert C.</creatorcontrib><creatorcontrib>Gruber, Stephen B.</creatorcontrib><creatorcontrib>Anton-Culver, Hoda</creatorcontrib><creatorcontrib>Klotz, Judith B.</creatorcontrib><creatorcontrib>Zanetti, Roberto</creatorcontrib><creatorcontrib>Gallagher, Richard P.</creatorcontrib><creatorcontrib>Dwyer, Terence</creatorcontrib><creatorcontrib>Rebbeck, Timothy R.</creatorcontrib><creatorcontrib>Berwick, Marianne</creatorcontrib><creatorcontrib>GEM Study Group</creatorcontrib><title>Familial Aggregation of Melanoma Risks in a Large Population-Based Sample of Melanoma Cases</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><description>Objective: Melanoma has been shown in numerous studies to be associated with sun exposure, and with host phenotypic factors of genetic origin. In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of incidence of melanoma in the first-degree relatives of these cases. Methods: A total of 2508 incident cases of melanoma provided information on basic demographic data and pigmentary characteristics, in addition to detailed information on family history of melanoma. These data were used to examine the incidence rates ratios of melanoma in the relatives of cases in relation to population rates, and also with respect to phenotypic characteristics of the probands that have been shown to be associated with melanoma: mole counts, hair color, eye color, and skin sensitivity to the sun. Results: The incidence rates reflect the underlying patterns of incidence in the source populations, with generally higher rates in the Australian sample, low rates in Italy, and intermediate rates in the USA and Canada. Also, rates are higher in men than in women, except at very young ages. Phenotypic characteristics of the probands were only weakly associated with the observed rates in the relatives although there is a strong inverse association with age at diagnosis. Cumulative risk of melanoma rises to 6.9% (6.1%) at age 80 in male (female) first-degree relatives of cases, and to 10.8% (9.5%) in relatives of cases diagnosed before age 50. Conclusions: Relatives of cases diagnosed with melanoma are at considerable lifetime risk of the disease, especially if the case is diagnosed at a young age.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aggregation</subject><subject>Australia - epidemiology</subject><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Disease prevention</subject><subject>Disease risk</subject><subject>Epidemiology</subject><subject>Family Health</subject><subject>Family history</subject><subject>Family medical history</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Hair</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Melanoma</subject><subject>Melanoma - epidemiology</subject><subject>Melanoma - genetics</subject><subject>Middle Aged</subject><subject>Nevus</subject><subject>North America - epidemiology</subject><subject>Phenotype</subject><subject>Population</subject><subject>Predisposing factors</subject><subject>Questionnaires</subject><subject>Risk factors</subject><subject>Sex Distribution</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkE1PGzEQhi1UVAL0ByBVlcWBm2HG9sS7RxrxJQWBoJw4WM6uN9p0N07t7IF_j2kiEJzmMM_7auZh7AjhFAHMWUIgkgJAC6mNFrjDRkhGCSMlfWMjKMkIklrtsf2UFgBAYwnf2R4SGSPLYsSeL13fdq3r-Pl8Hv3crduw5KHht75zy9A7_tCmv4m3S-741MW55_dhNXT_OfHbJV_zR9evOv8pNMmLdMh2G9cl_2M7D9jT5cWfybWY3l3dTM6nolIlrEVTlAVWpKjGBouCEDXMnJd6bNDT2HgsalMbaGRJVUFQo2oqbar8-yxHpTpgJ5veVQz_Bp_Wtm9T5bt8iw9DsrkndxmdweMv4CIMcZlvsxJVlqlLyhBuoCqGlKJv7Cq2vYsvFsG-abcb7TZrt2_aLebMr23xMOt9_ZHYes7Azw2wSOsQ3_eKSI2B1Cumi4RW</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Begg, Colin B.</creator><creator>Hummer, Amanda</creator><creator>Mujumdar, Urvi</creator><creator>Armstrong, Bruce K.</creator><creator>Kricker, Anne</creator><creator>Marrett, Loraine D.</creator><creator>Millikan, Robert C.</creator><creator>Gruber, Stephen B.</creator><creator>Anton-Culver, Hoda</creator><creator>Klotz, Judith B.</creator><creator>Zanetti, Roberto</creator><creator>Gallagher, Richard P.</creator><creator>Dwyer, Terence</creator><creator>Rebbeck, Timothy R.</creator><creator>Berwick, Marianne</creator><general>Kluwer Academic Publishers</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20041101</creationdate><title>Familial Aggregation of Melanoma Risks in a Large Population-Based Sample of Melanoma Cases</title><author>Begg, Colin B. ; Hummer, Amanda ; Mujumdar, Urvi ; Armstrong, Bruce K. ; Kricker, Anne ; Marrett, Loraine D. ; Millikan, Robert C. ; Gruber, Stephen B. ; Anton-Culver, Hoda ; Klotz, Judith B. ; Zanetti, Roberto ; Gallagher, Richard P. ; Dwyer, Terence ; Rebbeck, Timothy R. ; Berwick, Marianne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-f8981c535d1f18851140bae24671e567e18d7d70f295c850d13fc47c055b89823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aggregation</topic><topic>Australia - epidemiology</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Disease prevention</topic><topic>Disease risk</topic><topic>Epidemiology</topic><topic>Family Health</topic><topic>Family history</topic><topic>Family medical history</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Hair</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Melanoma</topic><topic>Melanoma - epidemiology</topic><topic>Melanoma - genetics</topic><topic>Middle Aged</topic><topic>Nevus</topic><topic>North America - epidemiology</topic><topic>Phenotype</topic><topic>Population</topic><topic>Predisposing factors</topic><topic>Questionnaires</topic><topic>Risk factors</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Begg, Colin B.</creatorcontrib><creatorcontrib>Hummer, Amanda</creatorcontrib><creatorcontrib>Mujumdar, Urvi</creatorcontrib><creatorcontrib>Armstrong, Bruce K.</creatorcontrib><creatorcontrib>Kricker, Anne</creatorcontrib><creatorcontrib>Marrett, Loraine D.</creatorcontrib><creatorcontrib>Millikan, Robert C.</creatorcontrib><creatorcontrib>Gruber, Stephen B.</creatorcontrib><creatorcontrib>Anton-Culver, Hoda</creatorcontrib><creatorcontrib>Klotz, Judith B.</creatorcontrib><creatorcontrib>Zanetti, Roberto</creatorcontrib><creatorcontrib>Gallagher, Richard P.</creatorcontrib><creatorcontrib>Dwyer, Terence</creatorcontrib><creatorcontrib>Rebbeck, Timothy R.</creatorcontrib><creatorcontrib>Berwick, Marianne</creatorcontrib><creatorcontrib>GEM Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Begg, Colin B.</au><au>Hummer, Amanda</au><au>Mujumdar, Urvi</au><au>Armstrong, Bruce K.</au><au>Kricker, Anne</au><au>Marrett, Loraine D.</au><au>Millikan, Robert C.</au><au>Gruber, Stephen B.</au><au>Anton-Culver, Hoda</au><au>Klotz, Judith B.</au><au>Zanetti, Roberto</au><au>Gallagher, Richard P.</au><au>Dwyer, Terence</au><au>Rebbeck, Timothy R.</au><au>Berwick, Marianne</au><aucorp>GEM Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Familial Aggregation of Melanoma Risks in a Large Population-Based Sample of Melanoma Cases</atitle><jtitle>Cancer causes & control</jtitle><addtitle>Cancer Causes Control</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>15</volume><issue>9</issue><spage>957</spage><epage>965</epage><pages>957-965</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Objective: Melanoma has been shown in numerous studies to be associated with sun exposure, and with host phenotypic factors of genetic origin. In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of incidence of melanoma in the first-degree relatives of these cases. Methods: A total of 2508 incident cases of melanoma provided information on basic demographic data and pigmentary characteristics, in addition to detailed information on family history of melanoma. These data were used to examine the incidence rates ratios of melanoma in the relatives of cases in relation to population rates, and also with respect to phenotypic characteristics of the probands that have been shown to be associated with melanoma: mole counts, hair color, eye color, and skin sensitivity to the sun. Results: The incidence rates reflect the underlying patterns of incidence in the source populations, with generally higher rates in the Australian sample, low rates in Italy, and intermediate rates in the USA and Canada. Also, rates are higher in men than in women, except at very young ages. Phenotypic characteristics of the probands were only weakly associated with the observed rates in the relatives although there is a strong inverse association with age at diagnosis. Cumulative risk of melanoma rises to 6.9% (6.1%) at age 80 in male (female) first-degree relatives of cases, and to 10.8% (9.5%) in relatives of cases diagnosed before age 50. Conclusions: Relatives of cases diagnosed with melanoma are at considerable lifetime risk of the disease, especially if the case is diagnosed at a young age.</abstract><cop>Netherlands</cop><pub>Kluwer Academic Publishers</pub><pmid>15577298</pmid><doi>10.1007/s10552-004-2474-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Age Factors Aged Aggregation Australia - epidemiology Cancer Cohort Studies Disease prevention Disease risk Epidemiology Family Health Family history Family medical history Female Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Hair Humans Incidence Male Medical genetics Melanoma Melanoma - epidemiology Melanoma - genetics Middle Aged Nevus North America - epidemiology Phenotype Population Predisposing factors Questionnaires Risk factors Sex Distribution |
| title | Familial Aggregation of Melanoma Risks in a Large Population-Based Sample of Melanoma Cases |
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