Silencing of Fas-associated Death Domain Protects Mice from Septic Lung Inflammation and Apoptosis

A better understanding of the molecular mechanisms involved in the pathogenesis of sepsis and its resultant organ failure and new therapeutic approaches and targets are urgently needed. Accumulating evidence suggests that apoptosis plays an important role in the pathophysiology of sepsis and that ap...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of respiratory and critical care medicine 2009-05, Vol.179 (9), p.806-815
Hauptverfasser:	Matsuda, Naoyuki, Yamamoto, Seiji, Takano, Ken-ichi, Kageyama, Shun-ichiro, Kurobe, Yusuke, Yoshihara, Yasunori, Takano, Yasuo, Hattori, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Acute Lung Injury - pathology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Apoptosis Biological and medical sciences Caspase 8 - metabolism Cell death Fas-Associated Death Domain Protein - genetics Fas-Associated Death Domain Protein - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Silencing Hydrogen-Ion Concentration Immunobiology In Situ Nick-End Labeling Intensive care medicine Ligands Lung - pathology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Male Medical sciences Mice Mice, Inbred BALB C Mortality Nitric Oxide Synthase Type II - metabolism Proteins Reagents Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism RNA, Small Interfering - administration & dosage Sepsis Sepsis - pathology Spleen - pathology TNF Receptor-Associated Death Domain Protein - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!