VEGF and angiogenesis in acute and chronic MOG(35–55) peptide induced EAE

Abstract An increased expression of vascular endothelial growth factor (VEGF) is associated with demyelinated lesions in both multiple sclerosis (MS) and its model (EAE), implicating changes in vasculature as a potential component of CNS plaque formation. The purpose of this study was to investigate...

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Veröffentlicht in:	Journal of neuroimmunology 2009-04, Vol.209 (1), p.6-15
Hauptverfasser:	Roscoe, W.A, Welsh, M.E, Carter, D.E, Karlik, S.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanyl aminopeptidase Allergy and Immunology Angiogenesis Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Angiogenic Proteins - genetics Animals Blood Vessels - drug effects Blood Vessels - metabolism Blood Vessels - pathology Caspase 8 Disease Models, Animal EAE Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Female Glycoproteins Hif1a Indoles - pharmacology Indoles - therapeutic use Laminin Laminin - drug effects Laminin - metabolism Mice Mice, Inbred C57BL MMP-19 Multiple sclerosis Myelin Sheath - drug effects Myelin Sheath - immunology Myelin Sheath - pathology Myelin-Oligodendrocyte Glycoprotein Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - physiopathology Neurology Peptide Fragments Plasminogen activator inhibitor Pyrroles - pharmacology Pyrroles - therapeutic use Remyelination RNA, Messenger - drug effects RNA, Messenger - metabolism Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology SU5416 Thrombospondin Up-Regulation - drug effects Up-Regulation - physiology Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF Wallerian Degeneration - chemically induced Wallerian Degeneration - pathology Wallerian Degeneration - physiopathology
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