Stage specific over-expression of the dominant negative Ikaros 6 reveals distinct role of Ikaros throughout human B-cell differentiation

Ikaros is a transcription factor that acts both as an activator and as an inhibitor of gene expression in several hematopoietic lineages. Ikaros functions in hematopoiesis have mostly been studied in mice, and are notably crucial for lymphopoiesis. Deregulation of Ikaros expression was evidenced in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular immunology 2009-05, Vol.46 (8), p.1736-1743
Hauptverfasser:	Tonnelle, Cécile, Dijon, Marilyne, Moreau, Thomas, Garulli, Céline, Bardin, Florence, Chabannon, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - metabolism B lymphocytes B-Lymphocytes - metabolism B-Lymphocytes - physiology Cell Differentiation - genetics Cell Line Female Genes, Dominant - physiology Human hematopoietic differentiation Humans Ikaros Ikaros Transcription Factor - genetics Ikaros Transcription Factor - metabolism Ikaros Transcription Factor - physiology Jurkat Cells Lentiviral vectors Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic Pregnancy Time Factors Transcription factors Transduction, Genetic Transplantation, Heterologous Up-Regulation - genetics Xeno-transplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!