Genetic risk factors for infection in patients with early rheumatoid arthritis

We analyzed clinical and genetic factors contributing to infections in 457 subjects with early rheumatoid arthritis (RA) enrolled in a prospective, 1-year clinical trial of methotrexate and the TNF inhibitor etanercept. Subjects were genotyped for the following single nucleotide polymorphisms (SNPs)...

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Veröffentlicht in:	Genes and immunity 2004-12, Vol.5 (8), p.641-647
Hauptverfasser:	Hughes, L B, Criswell, L A, Beasley, T M, Edberg, J C, Kimberly, R P, Moreland, L W, Seldin, M F, Bridges, S L
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Alleles Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - genetics Biomedical and Life Sciences Biomedicine Cancer Research Complications and side effects Disease susceptibility Etanercept Fc receptors Female full-paper Gene Expression Genetic aspects Genetic factors Genetic Predisposition to Disease Genotype Genotype & phenotype Human Genetics Humans Immunoglobulin G - therapeutic use Immunology Infection Leukocytes (neutrophilic) Lymphotoxin Lymphotoxin-alpha - genetics Male Methotrexate Methotrexate - therapeutic use Middle Aged Polymorphism, Single Nucleotide Prospective Studies Receptors, IgG - genetics Receptors, Tumor Necrosis Factor - therapeutic use Rheumatoid arthritis Risk Factors Single-nucleotide polymorphism Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-β Urinary tract Urinary tract infections Urinary Tract Infections - complications Urinary Tract Infections - genetics Viral infections
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