Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE
Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total se...
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| Veröffentlicht in: | Allergy 2009-05, Vol.64 (5), p.746-753 |
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| creator | Tewfik, M.A Bossé, Y Lemire, M Hudson, T.J Vallée-Smejda, S Al-Shemari, H Laprise, C Desrosiers, M |
| description | Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE level. A population of 206 patients with severe chronic rhinosinusitis (CRS) was used. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for measurement of total serum IgE, as well as DNA extraction. A maximally informative set of SNPs in the TLR1, 2, 3, 4, 6, 9, 10, CD14, MD2, MyD88, IRAK4, and TRAF6 genes were selected and genotyped. Significant findings were replicated in a second independent population of 956 subjects from 227 families with asthma. A total of 97 out of 104 SNPs were successfully genotyped. Three SNPs in IRAK4- rs1461567, rs4251513, and rs4251559 - were associated with total serum IgE levels (P < 0.004). In the replication sample, the same SNPs as well as the same orientation of the risk allele were associated with IgE levels (P < 0.031). These results demonstrate a clear association between polymorphisms in the IRAK4 gene and serum IgE levels in patients with CRS and asthma. IRAK4 may be important in the regulation of IgE levels in patients with inflammatory diseases of the airways. |
| doi_str_mv | 10.1111/j.1398-9995.2008.01889.x |
| format | Article |
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We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE level. A population of 206 patients with severe chronic rhinosinusitis (CRS) was used. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for measurement of total serum IgE, as well as DNA extraction. A maximally informative set of SNPs in the TLR1, 2, 3, 4, 6, 9, 10, CD14, MD2, MyD88, IRAK4, and TRAF6 genes were selected and genotyped. Significant findings were replicated in a second independent population of 956 subjects from 227 families with asthma. A total of 97 out of 104 SNPs were successfully genotyped. Three SNPs in IRAK4- rs1461567, rs4251513, and rs4251559 - were associated with total serum IgE levels (P < 0.004). In the replication sample, the same SNPs as well as the same orientation of the risk allele were associated with IgE levels (P < 0.031). These results demonstrate a clear association between polymorphisms in the IRAK4 gene and serum IgE levels in patients with CRS and asthma. IRAK4 may be important in the regulation of IgE levels in patients with inflammatory diseases of the airways.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>EISSN: 0108-1675</identifier><identifier>DOI: 10.1111/j.1398-9995.2008.01889.x</identifier><identifier>PMID: 19254290</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Adult ; Allergies ; asthma ; Biological and medical sciences ; Chronic Disease ; Chronic obstructive pulmonary disease, asthma ; chronic rhinosinusitis ; Cross-Sectional Studies ; Cytokines ; Dermatology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Frequency - genetics ; Gene Frequency - immunology ; genetics innate immunity ; Genotype ; Genotype & phenotype ; Humans ; Hypersensitivity - genetics ; Hypersensitivity - immunology ; Immune system ; immunoglobulin E ; Immunoglobulin E - blood ; Immunoglobulins ; Interleukin-1 Receptor-Associated Kinases - genetics ; Interleukin-1 Receptor-Associated Kinases - immunology ; Linkage Disequilibrium ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Polymorphism ; Polymorphism, Single Nucleotide ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Surveys and Questionnaires</subject><ispartof>Allergy, 2009-05, Vol.64 (5), p.746-753</ispartof><rights>2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard</rights><rights>2009 INIST-CNRS</rights><rights>Journal compilation © 2009 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4799-53b7b0ed4f36956742c906a752987084624169bb65a11c0817110cfe6d9010b63</citedby><cites>FETCH-LOGICAL-c4799-53b7b0ed4f36956742c906a752987084624169bb65a11c0817110cfe6d9010b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1398-9995.2008.01889.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1398-9995.2008.01889.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21354529$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19254290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tewfik, M.A</creatorcontrib><creatorcontrib>Bossé, Y</creatorcontrib><creatorcontrib>Lemire, M</creatorcontrib><creatorcontrib>Hudson, T.J</creatorcontrib><creatorcontrib>Vallée-Smejda, S</creatorcontrib><creatorcontrib>Al-Shemari, H</creatorcontrib><creatorcontrib>Laprise, C</creatorcontrib><creatorcontrib>Desrosiers, M</creatorcontrib><title>Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE</title><title>Allergy</title><addtitle>Allergy</addtitle><description>Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE level. A population of 206 patients with severe chronic rhinosinusitis (CRS) was used. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for measurement of total serum IgE, as well as DNA extraction. A maximally informative set of SNPs in the TLR1, 2, 3, 4, 6, 9, 10, CD14, MD2, MyD88, IRAK4, and TRAF6 genes were selected and genotyped. Significant findings were replicated in a second independent population of 956 subjects from 227 families with asthma. A total of 97 out of 104 SNPs were successfully genotyped. Three SNPs in IRAK4- rs1461567, rs4251513, and rs4251559 - were associated with total serum IgE levels (P < 0.004). In the replication sample, the same SNPs as well as the same orientation of the risk allele were associated with IgE levels (P < 0.031). These results demonstrate a clear association between polymorphisms in the IRAK4 gene and serum IgE levels in patients with CRS and asthma. IRAK4 may be important in the regulation of IgE levels in patients with inflammatory diseases of the airways.</description><subject>Adult</subject><subject>Allergies</subject><subject>asthma</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>chronic rhinosinusitis</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Frequency - genetics</subject><subject>Gene Frequency - immunology</subject><subject>genetics innate immunity</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Hypersensitivity - genetics</subject><subject>Hypersensitivity - immunology</subject><subject>Immune system</subject><subject>immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulins</subject><subject>Interleukin-1 Receptor-Associated Kinases - genetics</subject><subject>Interleukin-1 Receptor-Associated Kinases - immunology</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Surveys and Questionnaires</subject><issn>0105-4538</issn><issn>1398-9995</issn><issn>0108-1675</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EokvhFcBCglvCjGM79oFDVRWotBJI0LPleJ02SxIvdqJ2374Ou2oRF7AseeT5_hmPf0IoQol5fdiWWGlVaK1FyQBUCaiULu-ekNVD4ilZAYIouKjUCXmR0hYAaqbhOTlBzQTP4YqYb6HfDyHubro0JNqNeU8-9n7-2Y0F0uid300hFjal4Do7-Q3NGZs85dRGT_-4v-2mGzqFyfY0-TgP9PL64iV51to--VfH85Rcfbr4cf6lWH_9fHl-ti4cr7UuRNXUDfgNbyuphaw5cxqkrQXTqgbFJeModdNIYREdKKwRwbVebnQespHVKXl_qLuL4dfs02SGLjnf93b0YU5G1siFYPBPkIGoUUqVwbd_gdswxzEPYVBLjbkxy5A6QC6GlKJvzS52g417g2AWq8zWLI6YxRGzWGV-W2XusvT1sf7cDH7zKDx6k4F3R8AmZ_s22tF16YFjWAme_ydzHw_cbdf7_X8_wJyt10uU9W8O-tYGY69j7nH1nQFWgBKZkljdA5TVtkg</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Tewfik, M.A</creator><creator>Bossé, Y</creator><creator>Lemire, M</creator><creator>Hudson, T.J</creator><creator>Vallée-Smejda, S</creator><creator>Al-Shemari, H</creator><creator>Laprise, C</creator><creator>Desrosiers, M</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200905</creationdate><title>Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE</title><author>Tewfik, M.A ; Bossé, Y ; Lemire, M ; Hudson, T.J ; Vallée-Smejda, S ; Al-Shemari, H ; Laprise, C ; Desrosiers, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4799-53b7b0ed4f36956742c906a752987084624169bb65a11c0817110cfe6d9010b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Allergies</topic><topic>asthma</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>chronic rhinosinusitis</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Frequency - genetics</topic><topic>Gene Frequency - immunology</topic><topic>genetics innate immunity</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Hypersensitivity - genetics</topic><topic>Hypersensitivity - immunology</topic><topic>Immune system</topic><topic>immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulins</topic><topic>Interleukin-1 Receptor-Associated Kinases - genetics</topic><topic>Interleukin-1 Receptor-Associated Kinases - immunology</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tewfik, M.A</creatorcontrib><creatorcontrib>Bossé, Y</creatorcontrib><creatorcontrib>Lemire, M</creatorcontrib><creatorcontrib>Hudson, T.J</creatorcontrib><creatorcontrib>Vallée-Smejda, S</creatorcontrib><creatorcontrib>Al-Shemari, H</creatorcontrib><creatorcontrib>Laprise, C</creatorcontrib><creatorcontrib>Desrosiers, M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tewfik, M.A</au><au>Bossé, Y</au><au>Lemire, M</au><au>Hudson, T.J</au><au>Vallée-Smejda, S</au><au>Al-Shemari, H</au><au>Laprise, C</au><au>Desrosiers, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE</atitle><jtitle>Allergy</jtitle><addtitle>Allergy</addtitle><date>2009-05</date><risdate>2009</risdate><volume>64</volume><issue>5</issue><spage>746</spage><epage>753</epage><pages>746-753</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><eissn>0108-1675</eissn><coden>LLRGDY</coden><abstract>Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE level. A population of 206 patients with severe chronic rhinosinusitis (CRS) was used. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for measurement of total serum IgE, as well as DNA extraction. A maximally informative set of SNPs in the TLR1, 2, 3, 4, 6, 9, 10, CD14, MD2, MyD88, IRAK4, and TRAF6 genes were selected and genotyped. Significant findings were replicated in a second independent population of 956 subjects from 227 families with asthma. A total of 97 out of 104 SNPs were successfully genotyped. Three SNPs in IRAK4- rs1461567, rs4251513, and rs4251559 - were associated with total serum IgE levels (P < 0.004). In the replication sample, the same SNPs as well as the same orientation of the risk allele were associated with IgE levels (P < 0.031). These results demonstrate a clear association between polymorphisms in the IRAK4 gene and serum IgE levels in patients with CRS and asthma. IRAK4 may be important in the regulation of IgE levels in patients with inflammatory diseases of the airways.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>19254290</pmid><doi>10.1111/j.1398-9995.2008.01889.x</doi><tpages>8</tpages></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Allergies asthma Biological and medical sciences Chronic Disease Chronic obstructive pulmonary disease, asthma chronic rhinosinusitis Cross-Sectional Studies Cytokines Dermatology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Frequency - genetics Gene Frequency - immunology genetics innate immunity Genotype Genotype & phenotype Humans Hypersensitivity - genetics Hypersensitivity - immunology Immune system immunoglobulin E Immunoglobulin E - blood Immunoglobulins Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - immunology Linkage Disequilibrium Male Medical sciences Middle Aged Pneumology Polymorphism Polymorphism, Single Nucleotide Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Surveys and Questionnaires |
| title | Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE |
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