Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats

The kinetics of albendazole metabolites and albendazole sulphoxide enantiomers were studied in 2- and 14-month-old female and male goats, after a single oral dose administration (10 mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12...

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Veröffentlicht in:	Research in veterinary science 2009-06, Vol.86 (3), p.498-502
Hauptverfasser:	Capece, B.P.S., Afonso, S.M.S., Lazáro, R., Harun, M., Godoy, C., Castells, G., Cristòfol, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging - physiology Albendazole Albendazole - analogs & derivatives Albendazole - blood Albendazole - pharmacokinetics albendazole sulfoxide Albendazole sulphoxide animal age Animals Anthelmintics - blood Anthelmintics - pharmacokinetics Antiprotozoal Agents - blood Antiprotozoal Agents - pharmacokinetics blood chemistry dosage Drug dosages Enantiomers Female females Gender Gender differences Goats Goats - metabolism high performance liquid chromatography Male males Metabolites oral administration Parasites Pharmacokinetics Regression Analysis Sex Characteristics Sheep temporal variation Veterinary medicine
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