Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats
The kinetics of albendazole metabolites and albendazole sulphoxide enantiomers were studied in 2- and 14-month-old female and male goats, after a single oral dose administration (10 mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12...
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| Veröffentlicht in: | Research in veterinary science 2009-06, Vol.86 (3), p.498-502 |
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| creator | Capece, B.P.S. Afonso, S.M.S. Lazáro, R. Harun, M. Godoy, C. Castells, G. Cristòfol, C. |
| description | The kinetics of albendazole metabolites and albendazole sulphoxide enantiomers were studied in 2- and 14-month-old female and male goats, after a single oral dose administration (10
mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 30, 36, 42, 48 and 54
h post-treatment and analyzed using a high performance liquid chromatography method. In all groups the area under the plasma concentration-time curve (AUC) and peak concentration (
C
max) values of (+)-ABZSO were significantly higher than those of (−)-ABZSO. The AUC and
C
max values obtained for (+)-ABZSO and (−)-ABZSO in adult animals were higher compared to the results in young animals, showing significant differences except for (+)-ABZSO in female animals. In young animals, independently of gender, the
C
max appeared earlier compared to adult animals. The mean residence time (MRT) values were shorter in young animals compared to adult animals for all compounds analyzed. No sex-related differences were found for any of the parameters calculated except for the (+)-ABZSO from adult animals. |
| doi_str_mv | 10.1016/j.rvsc.2008.08.002 |
| format | Article |
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mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 30, 36, 42, 48 and 54
h post-treatment and analyzed using a high performance liquid chromatography method. In all groups the area under the plasma concentration-time curve (AUC) and peak concentration (
C
max) values of (+)-ABZSO were significantly higher than those of (−)-ABZSO. The AUC and
C
max values obtained for (+)-ABZSO and (−)-ABZSO in adult animals were higher compared to the results in young animals, showing significant differences except for (+)-ABZSO in female animals. In young animals, independently of gender, the
C
max appeared earlier compared to adult animals. The mean residence time (MRT) values were shorter in young animals compared to adult animals for all compounds analyzed. No sex-related differences were found for any of the parameters calculated except for the (+)-ABZSO from adult animals.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2008.08.002</identifier><identifier>PMID: 18805559</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Age ; Aging - physiology ; Albendazole ; Albendazole - analogs & derivatives ; Albendazole - blood ; Albendazole - pharmacokinetics ; albendazole sulfoxide ; Albendazole sulphoxide ; animal age ; Animals ; Anthelmintics - blood ; Anthelmintics - pharmacokinetics ; Antiprotozoal Agents - blood ; Antiprotozoal Agents - pharmacokinetics ; blood chemistry ; dosage ; Drug dosages ; Enantiomers ; Female ; females ; Gender ; Gender differences ; Goats ; Goats - metabolism ; high performance liquid chromatography ; Male ; males ; Metabolites ; oral administration ; Parasites ; Pharmacokinetics ; Regression Analysis ; Sex Characteristics ; Sheep ; temporal variation ; Veterinary medicine</subject><ispartof>Research in veterinary science, 2009-06, Vol.86 (3), p.498-502</ispartof><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-e0c7b59bbe2bda570c6cfb88efc776a1d5b578ef959a358a6af7c7c4fc72c4473</citedby><cites>FETCH-LOGICAL-c406t-e0c7b59bbe2bda570c6cfb88efc776a1d5b578ef959a358a6af7c7c4fc72c4473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rvsc.2008.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18805559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capece, B.P.S.</creatorcontrib><creatorcontrib>Afonso, S.M.S.</creatorcontrib><creatorcontrib>Lazáro, R.</creatorcontrib><creatorcontrib>Harun, M.</creatorcontrib><creatorcontrib>Godoy, C.</creatorcontrib><creatorcontrib>Castells, G.</creatorcontrib><creatorcontrib>Cristòfol, C.</creatorcontrib><title>Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The kinetics of albendazole metabolites and albendazole sulphoxide enantiomers were studied in 2- and 14-month-old female and male goats, after a single oral dose administration (10
mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 30, 36, 42, 48 and 54
h post-treatment and analyzed using a high performance liquid chromatography method. In all groups the area under the plasma concentration-time curve (AUC) and peak concentration (
C
max) values of (+)-ABZSO were significantly higher than those of (−)-ABZSO. The AUC and
C
max values obtained for (+)-ABZSO and (−)-ABZSO in adult animals were higher compared to the results in young animals, showing significant differences except for (+)-ABZSO in female animals. In young animals, independently of gender, the
C
max appeared earlier compared to adult animals. The mean residence time (MRT) values were shorter in young animals compared to adult animals for all compounds analyzed. No sex-related differences were found for any of the parameters calculated except for the (+)-ABZSO from adult animals.</description><subject>Age</subject><subject>Aging - physiology</subject><subject>Albendazole</subject><subject>Albendazole - analogs & derivatives</subject><subject>Albendazole - blood</subject><subject>Albendazole - pharmacokinetics</subject><subject>albendazole sulfoxide</subject><subject>Albendazole sulphoxide</subject><subject>animal age</subject><subject>Animals</subject><subject>Anthelmintics - blood</subject><subject>Anthelmintics - pharmacokinetics</subject><subject>Antiprotozoal Agents - blood</subject><subject>Antiprotozoal Agents - pharmacokinetics</subject><subject>blood chemistry</subject><subject>dosage</subject><subject>Drug dosages</subject><subject>Enantiomers</subject><subject>Female</subject><subject>females</subject><subject>Gender</subject><subject>Gender differences</subject><subject>Goats</subject><subject>Goats - metabolism</subject><subject>high performance liquid chromatography</subject><subject>Male</subject><subject>males</subject><subject>Metabolites</subject><subject>oral administration</subject><subject>Parasites</subject><subject>Pharmacokinetics</subject><subject>Regression Analysis</subject><subject>Sex Characteristics</subject><subject>Sheep</subject><subject>temporal variation</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVpaLZp_0APraHQm7cj2fow9BJC-gGBHNKchSyPd7W1pa1kh7a_PnK90NJDYWAY5nlfhnkJeUVhS4GK94dtfEh2ywDUdilgT8iG8oqVTAj6lGwAqrrkTKlz8jylAwDUlMpn5JwqBZzzZkPCdd-jnYrQF2aHhfFdsUPfYSycL6Y9Fse9iaOx4ZvzODmbfpNDmxnzKwyr4u85zcNxH364Dgv0xk8ujBjT4rYLZkovyFlvhoQvT_2C3H-8_nr1uby5_fTl6vKmtDWIqUSwsuVN2yJrO8MlWGH7VinsrZTC0I63XOap4Y2puDLC9NJKW-c1s3UtqwvybvU9xvB9xjTp0SWLw2A8hjlpIWldg4IMvv0HPIQ5-nybplBxqBrJRabYStkYUorY62N0o4k_M6SXMPRBL2HoJQy9FLAsen2yntsRuz-S0_cz8GYFehO02UWX9P0dA1plQ8EkrTLxYSUw_-rBYdTJOvQWOxdzbLoL7n8XPAKMOKYO</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Capece, B.P.S.</creator><creator>Afonso, S.M.S.</creator><creator>Lazáro, R.</creator><creator>Harun, M.</creator><creator>Godoy, C.</creator><creator>Castells, G.</creator><creator>Cristòfol, C.</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats</title><author>Capece, B.P.S. ; Afonso, S.M.S. ; Lazáro, R. ; Harun, M. ; Godoy, C. ; Castells, G. ; Cristòfol, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-e0c7b59bbe2bda570c6cfb88efc776a1d5b578ef959a358a6af7c7c4fc72c4473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age</topic><topic>Aging - physiology</topic><topic>Albendazole</topic><topic>Albendazole - analogs & derivatives</topic><topic>Albendazole - blood</topic><topic>Albendazole - pharmacokinetics</topic><topic>albendazole sulfoxide</topic><topic>Albendazole sulphoxide</topic><topic>animal age</topic><topic>Animals</topic><topic>Anthelmintics - blood</topic><topic>Anthelmintics - pharmacokinetics</topic><topic>Antiprotozoal Agents - blood</topic><topic>Antiprotozoal Agents - pharmacokinetics</topic><topic>blood chemistry</topic><topic>dosage</topic><topic>Drug dosages</topic><topic>Enantiomers</topic><topic>Female</topic><topic>females</topic><topic>Gender</topic><topic>Gender differences</topic><topic>Goats</topic><topic>Goats - metabolism</topic><topic>high performance liquid chromatography</topic><topic>Male</topic><topic>males</topic><topic>Metabolites</topic><topic>oral administration</topic><topic>Parasites</topic><topic>Pharmacokinetics</topic><topic>Regression Analysis</topic><topic>Sex Characteristics</topic><topic>Sheep</topic><topic>temporal variation</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capece, B.P.S.</creatorcontrib><creatorcontrib>Afonso, S.M.S.</creatorcontrib><creatorcontrib>Lazáro, R.</creatorcontrib><creatorcontrib>Harun, M.</creatorcontrib><creatorcontrib>Godoy, C.</creatorcontrib><creatorcontrib>Castells, G.</creatorcontrib><creatorcontrib>Cristòfol, C.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capece, B.P.S.</au><au>Afonso, S.M.S.</au><au>Lazáro, R.</au><au>Harun, M.</au><au>Godoy, C.</au><au>Castells, G.</au><au>Cristòfol, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>86</volume><issue>3</issue><spage>498</spage><epage>502</epage><pages>498-502</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The kinetics of albendazole metabolites and albendazole sulphoxide enantiomers were studied in 2- and 14-month-old female and male goats, after a single oral dose administration (10
mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 30, 36, 42, 48 and 54
h post-treatment and analyzed using a high performance liquid chromatography method. In all groups the area under the plasma concentration-time curve (AUC) and peak concentration (
C
max) values of (+)-ABZSO were significantly higher than those of (−)-ABZSO. The AUC and
C
max values obtained for (+)-ABZSO and (−)-ABZSO in adult animals were higher compared to the results in young animals, showing significant differences except for (+)-ABZSO in female animals. In young animals, independently of gender, the
C
max appeared earlier compared to adult animals. The mean residence time (MRT) values were shorter in young animals compared to adult animals for all compounds analyzed. No sex-related differences were found for any of the parameters calculated except for the (+)-ABZSO from adult animals.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>18805559</pmid><doi>10.1016/j.rvsc.2008.08.002</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 2009-06, Vol.86 (3), p.498-502 |
| issn | 0034-5288 1532-2661 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Age Aging - physiology Albendazole Albendazole - analogs & derivatives Albendazole - blood Albendazole - pharmacokinetics albendazole sulfoxide Albendazole sulphoxide animal age Animals Anthelmintics - blood Anthelmintics - pharmacokinetics Antiprotozoal Agents - blood Antiprotozoal Agents - pharmacokinetics blood chemistry dosage Drug dosages Enantiomers Female females Gender Gender differences Goats Goats - metabolism high performance liquid chromatography Male males Metabolites oral administration Parasites Pharmacokinetics Regression Analysis Sex Characteristics Sheep temporal variation Veterinary medicine |
| title | Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats |
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