Vasoactive intestinal peptide behaves as a pro-metastatic factor in human prostate cancer cells

BACKGROUND There is little known on the involvement of vasoactive intestinal peptide (VIP) in the metastatic cascade of human prostate cancer, that is, cell proliferation, cell–cell adhesion, extracellular‐matrix degradation, and migration/invasion. Here we evaluated the expression of related biomar...

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Veröffentlicht in:	The Prostate 2009-05, Vol.69 (7), p.774-786
Hauptverfasser:	Fernández-Martínez, Ana B., Bajo, Ana M., Sánchez-Chapado, Manuel, Prieto, Juan C., Carmena, María J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Biological and medical sciences Biomarkers, Tumor - biosynthesis Cadherins - biosynthesis Cell Adhesion - drug effects Cell Adhesion - physiology Cell Growth Processes - drug effects Cell Growth Processes - physiology Cell Line, Tumor Cell Movement - drug effects Cell Movement - physiology Curcumin - pharmacology Cyclin D1 - metabolism Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix - pathology GPI-Linked Proteins Gynecology. Andrology. Obstetrics Humans LNCaP and PC3 cells Male Male genital diseases Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Medical sciences Membrane Glycoproteins - biosynthesis metastatic cascade Microscopy, Confocal Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Nephrology. Urinary tract diseases prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction Tumors Tumors of the urinary system Urinary tract. Prostate gland Vasoactive Intestinal Peptide - metabolism Vasoactive Intestinal Peptide - pharmacology VIP
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