BMP-7 protects against progression of cartilage degeneration after impact injury

In vivo studies were used to characterize a model of cartilage injury leading to osteoarthritis progression in the medial femorotibial joint of sheep. In three subsequent studies, bilateral impact injuries were created and one joint received intraarticular injections of 340 µg of rhBMP‐7 protein in...

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Veröffentlicht in:	Journal of orthopaedic research 2009-05, Vol.27 (5), p.602-611
Hauptverfasser:	Hurtig, Mark, Chubinskaya, Susan, Dickey, Jim, Rueger, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - drug therapy Arthritis, Experimental - pathology BMP-7 Bone Morphogenetic Proteins - pharmacokinetics Bone Morphogenetic Proteins - therapeutic use Cartilage, Articular - drug effects Cartilage, Articular - injuries Cartilage, Articular - pathology Chondrocytes - metabolism Chondrocytes - pathology Disease Models, Animal Female Femur - injuries Hindlimb - injuries Humans impact injury In Situ Nick-End Labeling Injections, Intra-Articular Joints - injuries knee Knee Injuries - drug therapy Knee Injuries - pathology osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - pathology sheep
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