Suppressive Effect of Antibiotic Siomycin on Antibody Production
The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No. 806097) in search of antibody production inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cell independent antigen DNP-LPS (dinitrophenyl-lipo...
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| Veröffentlicht in: | Journal of antibiotics 2004/09/25, Vol.57(9), pp.590-596 |
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| container_title | Journal of antibiotics |
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| creator | UENO, MOTOI FURUKAWA, SATOKO ABE, FUMIE USHIODA, MICHIKO FUJINE, KIYOTAKA JOHKI, SHIGERU HATORI, HIDETAKA UEDA, HIROTSUGU |
| description | The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No. 806097) in search of antibody production inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cell independent antigen DNP-LPS (dinitrophenyl-lipopolysaccharide) while it also showed inhibitory effect against T-cell proliferation. Its inhibitory mechanism was considered to be different from that of FK506, the representative of T-cell immunosuppressant. Moreover, siomycin showed inhibitory effect in both T-cell dependent and independent murine antibody production models and decreased the severity in murine collagen arthritis model. Therefore, siomycin is a unique immunosuppressant which has potential for the treatment of some antibody-mediated diseases. |
| doi_str_mv | 10.7164/antibiotics.57.590 |
| format | Article |
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Its inhibitory mechanism was considered to be different from that of FK506, the representative of T-cell immunosuppressant. Moreover, siomycin showed inhibitory effect in both T-cell dependent and independent murine antibody production models and decreased the severity in murine collagen arthritis model. Therefore, siomycin is a unique immunosuppressant which has potential for the treatment of some antibody-mediated diseases.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.57.590</identifier><identifier>PMID: 15580960</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibody Formation - drug effects ; Arthritis, Experimental - drug therapy ; B-Lymphocytes - immunology ; Collagen ; Female ; Humans ; Immunosuppressive Agents - pharmacology ; Immunosuppressive Agents - therapeutic use ; Lymphocyte Activation - drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred DBA ; Peptides - pharmacology ; Peptides - therapeutic use ; T-Lymphocytes - immunology ; Tacrolimus - pharmacology ; Tacrolimus - therapeutic use ; Thiostrepton - pharmacology ; Thiostrepton - therapeutic use</subject><ispartof>The Journal of Antibiotics, 2004/09/25, Vol.57(9), pp.590-596</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-3b688417f867b89f5726c2c9854535c45bb48d29635e386833745fde485b12343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15580960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>UENO, MOTOI</creatorcontrib><creatorcontrib>FURUKAWA, SATOKO</creatorcontrib><creatorcontrib>ABE, FUMIE</creatorcontrib><creatorcontrib>USHIODA, MICHIKO</creatorcontrib><creatorcontrib>FUJINE, KIYOTAKA</creatorcontrib><creatorcontrib>JOHKI, SHIGERU</creatorcontrib><creatorcontrib>HATORI, HIDETAKA</creatorcontrib><creatorcontrib>UEDA, HIROTSUGU</creatorcontrib><title>Suppressive Effect of Antibiotic Siomycin on Antibody Production</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No. 806097) in search of antibody production inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cell independent antigen DNP-LPS (dinitrophenyl-lipopolysaccharide) while it also showed inhibitory effect against T-cell proliferation. Its inhibitory mechanism was considered to be different from that of FK506, the representative of T-cell immunosuppressant. Moreover, siomycin showed inhibitory effect in both T-cell dependent and independent murine antibody production models and decreased the severity in murine collagen arthritis model. Therefore, siomycin is a unique immunosuppressant which has potential for the treatment of some antibody-mediated diseases.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibody Formation - drug effects</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>B-Lymphocytes - immunology</subject><subject>Collagen</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred DBA</subject><subject>Peptides - pharmacology</subject><subject>Peptides - therapeutic use</subject><subject>T-Lymphocytes - immunology</subject><subject>Tacrolimus - pharmacology</subject><subject>Tacrolimus - therapeutic use</subject><subject>Thiostrepton - pharmacology</subject><subject>Thiostrepton - therapeutic use</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKw0AUQAdRbK3-gAvJyl3qTOa9s5T6wIJCdT0kk4lOSTJxJhH696Yk1O7c3AuXc8_iAHCN4JwjRu7SurWZda3VYU75nEp4AqZICBQjwuQpmEKYoFiIBE7ARQhbCDHHXJyDCaJUQMngFNxvuqbxJgT7Y6JVURjdRq6IFgd1tLGu2mlbR64ezi7fRW_e5Z1urasvwVmRlsFcjXsGPh5W78uneP36-LxcrGPNMG5jnDEhCOKFYDwTsqA8YTrRUlBCMdWEZhkReSIZpgYLJjDmhBa5IYJmKMEEz8Dt4G28--5MaFVlgzZlmdbGdUExjno9l_-CPQQhQqgHkwHU3oXgTaEab6vU7xSCah9YHQVWlKs-cP90M9q7rDL538tYtAdeBmAb2vTTHIDU95rSHDuRZGLvleOQ8EDpr9QrU-NfKe2Txg</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>UENO, MOTOI</creator><creator>FURUKAWA, SATOKO</creator><creator>ABE, FUMIE</creator><creator>USHIODA, MICHIKO</creator><creator>FUJINE, KIYOTAKA</creator><creator>JOHKI, SHIGERU</creator><creator>HATORI, HIDETAKA</creator><creator>UEDA, HIROTSUGU</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Suppressive Effect of Antibiotic Siomycin on Antibody Production</title><author>UENO, MOTOI ; FURUKAWA, SATOKO ; ABE, FUMIE ; USHIODA, MICHIKO ; FUJINE, KIYOTAKA ; JOHKI, SHIGERU ; HATORI, HIDETAKA ; UEDA, HIROTSUGU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c633t-3b688417f867b89f5726c2c9854535c45bb48d29635e386833745fde485b12343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibody Formation - drug effects</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>B-Lymphocytes - immunology</topic><topic>Collagen</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred DBA</topic><topic>Peptides - pharmacology</topic><topic>Peptides - therapeutic use</topic><topic>T-Lymphocytes - immunology</topic><topic>Tacrolimus - pharmacology</topic><topic>Tacrolimus - therapeutic use</topic><topic>Thiostrepton - pharmacology</topic><topic>Thiostrepton - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>UENO, MOTOI</creatorcontrib><creatorcontrib>FURUKAWA, SATOKO</creatorcontrib><creatorcontrib>ABE, FUMIE</creatorcontrib><creatorcontrib>USHIODA, MICHIKO</creatorcontrib><creatorcontrib>FUJINE, KIYOTAKA</creatorcontrib><creatorcontrib>JOHKI, SHIGERU</creatorcontrib><creatorcontrib>HATORI, HIDETAKA</creatorcontrib><creatorcontrib>UEDA, HIROTSUGU</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UENO, MOTOI</au><au>FURUKAWA, SATOKO</au><au>ABE, FUMIE</au><au>USHIODA, MICHIKO</au><au>FUJINE, KIYOTAKA</au><au>JOHKI, SHIGERU</au><au>HATORI, HIDETAKA</au><au>UEDA, HIROTSUGU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppressive Effect of Antibiotic Siomycin on Antibody Production</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>2004</date><risdate>2004</risdate><volume>57</volume><issue>9</issue><spage>590</spage><epage>596</epage><pages>590-596</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No. 806097) in search of antibody production inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cell independent antigen DNP-LPS (dinitrophenyl-lipopolysaccharide) while it also showed inhibitory effect against T-cell proliferation. Its inhibitory mechanism was considered to be different from that of FK506, the representative of T-cell immunosuppressant. Moreover, siomycin showed inhibitory effect in both T-cell dependent and independent murine antibody production models and decreased the severity in murine collagen arthritis model. 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| subjects | Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibody Formation - drug effects Arthritis, Experimental - drug therapy B-Lymphocytes - immunology Collagen Female Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Lymphocyte Activation - drug effects Male Mice Mice, Inbred BALB C Mice, Inbred DBA Peptides - pharmacology Peptides - therapeutic use T-Lymphocytes - immunology Tacrolimus - pharmacology Tacrolimus - therapeutic use Thiostrepton - pharmacology Thiostrepton - therapeutic use |
| title | Suppressive Effect of Antibiotic Siomycin on Antibody Production |
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