Low Levels of Estrogen Receptor β Protein Predict Resistance to Tamoxifen Therapy in Breast Cancer

Purpose: Breast cancer is a hormone-dependent cancer, and the presence of estrogen receptor α (ER-α) in tumors is used clinically to predict the likelihood of response to hormonal therapies. The clinical value of the second recently identified ER isoform, called ER-β, is less clear, and there is cur...

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Veröffentlicht in:	Clinical cancer research 2004-11, Vol.10 (22), p.7490-7499
Hauptverfasser:	Hopp, Torsten A, Weiss, Heidi L, Parra, Irma S, Cui, Yukun, Osborne, C Kent, Fuqua, Suzanne A W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Antineoplastic Agents, Hormonal - pharmacology Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Disease-Free Survival Drug Resistance, Neoplasm Estrogen Receptor beta - biosynthesis Estrogen Receptor beta - physiology Female Gynecology. Andrology. Obstetrics Humans Immunoblotting Ligands Lymphatic Metastasis Mammary gland diseases Medical sciences Middle Aged Multivariate Analysis Pharmacology. Drug treatments Prognosis Proportional Hazards Models Protein Isoforms Retrospective Studies Tamoxifen - therapeutic use Time Factors Tumors
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