Discovery of Novel Phenolic Antioxidants as Inhibitors of Vascular Cell Adhesion Molecule-1 Expression for Use in Chronic Inflammatory Diseases

Vascular cell adhesion molecule-1 (VCAM-1) mediates recruitment of leukocytes to endothelial cells and is implicated in many inflammatory conditions. Since part of the signal transduction pathway that regulates the activation of VCAM-1 expression is redox-sensitive, compounds with antioxidant proper...

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Veröffentlicht in:	Journal of medicinal chemistry 2004-12, Vol.47 (25), p.6420-6432
Hauptverfasser:	Meng, Charles Q, Somers, Patricia K, Hoong, Lee K, Zheng, X. Sharon, Ye, Zhihong, Worsencroft, Kimberly J, Simpson, Jacob E, Hotema, Martha R, Weingarten, M. David, MacDonald, Mathew L, Hill, Russell R, Marino, Elaine M, Suen, Ki-Ling, Luchoomun, Jayraz, Kunsch, Charles, Landers, Laura K, Stefanopoulos, Dimitria, Howard, Randy B, Sundell, Cynthia L, Saxena, Uday, Wasserman, Martin A, Sikorski, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anticholesteremic Agents - chemical synthesis Anticholesteremic Agents - chemistry Anticholesteremic Agents - pharmacology Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cells, Cultured Cholesterol, HDL - blood Cholesterol, LDL - blood Chronic Disease Cricetinae Depression, Chemical Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Humans Inflammation - drug therapy Interleukin-1 - antagonists & inhibitors Interleukin-1 - secretion Interleukin-6 - antagonists & inhibitors Interleukin-6 - secretion Male Medical sciences Mice Mice, Inbred BALB C Pharmacology. Drug treatments Phenols - chemical synthesis Phenols - chemistry Phenols - pharmacology Probucol - chemistry Structure-Activity Relationship Sulfides - chemical synthesis Sulfides - chemistry Sulfides - pharmacology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - secretion Vascular Cell Adhesion Molecule-1 - biosynthesis
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