Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: An FDG–PET study
Summary This study was to explore the relationship between scalp ictal EEG patterns and interictal hypometabolic patterns in hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) and determine the clinical significance of interictal hypometabolic patterns. Twenty-five patients wer...
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| Veröffentlicht in: | Epilepsy research 2009-04, Vol.84 (2), p.187-193 |
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| creator | Lee, Eun Mi Im, Ki Chun Kim, Ji Hyun Lee, Jung Kyo Hong, Seok Ho No, Young Joo Lee, Sang-Ahm Kim, Jae Seung Kang, Joong Koo |
| description | Summary This study was to explore the relationship between scalp ictal EEG patterns and interictal hypometabolic patterns in hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) and determine the clinical significance of interictal hypometabolic patterns. Twenty-five patients were classified into 2 groups based on initial ictal discharge (IID) frequency on scalp EEG: (a) those with a sustained regular 5- to 9-Hz rhythm with a restricted temporal or subtemporal distribution (group 1, N = 9); and (b) those with an irregular 2- to 5-Hz rhythm with a widespread distribution (group 2, N = 16). Using statistical parametric mapping, the PET results of each group were compared with age- and sex-matched controls to identify regions of significant hypometabolism, and the clinical characteristics were compared. Group 1 showed focal hypometabolism confined to the ipsilateral temporal lobe, whereas group 2 showed widespread hypometabolism in the ipsilateral temporal lobe, insular cortex and anterior part of the putamen. The two groups showed no significant differences in clinical characteristics. Among semiologic features, dystonic limb posturing was more frequently observed in group 2 ( p = 0.03). In summary, scalp EEG IID patterns in HS-MTLE can be important in determining hypometabolic patterns on interictal PET. Differences in hypometabolic patterns may reflect preferential pathways of ictal propagation rather than intrinsic epileptogenic regions. |
| doi_str_mv | 10.1016/j.eplepsyres.2009.02.005 |
| format | Article |
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Twenty-five patients were classified into 2 groups based on initial ictal discharge (IID) frequency on scalp EEG: (a) those with a sustained regular 5- to 9-Hz rhythm with a restricted temporal or subtemporal distribution (group 1, N = 9); and (b) those with an irregular 2- to 5-Hz rhythm with a widespread distribution (group 2, N = 16). Using statistical parametric mapping, the PET results of each group were compared with age- and sex-matched controls to identify regions of significant hypometabolism, and the clinical characteristics were compared. Group 1 showed focal hypometabolism confined to the ipsilateral temporal lobe, whereas group 2 showed widespread hypometabolism in the ipsilateral temporal lobe, insular cortex and anterior part of the putamen. The two groups showed no significant differences in clinical characteristics. Among semiologic features, dystonic limb posturing was more frequently observed in group 2 ( p = 0.03). In summary, scalp EEG IID patterns in HS-MTLE can be important in determining hypometabolic patterns on interictal PET. Differences in hypometabolic patterns may reflect preferential pathways of ictal propagation rather than intrinsic epileptogenic regions.</description><identifier>ISSN: 0920-1211</identifier><identifier>EISSN: 1872-6844</identifier><identifier>DOI: 10.1016/j.eplepsyres.2009.02.005</identifier><identifier>PMID: 19285834</identifier><identifier>CODEN: EPIRE8</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Brain Mapping ; Dystonic posture ; Electrodiagnosis. Electric activity recording ; Electroencephalography ; Epilepsy, Temporal Lobe - complications ; Epilepsy, Temporal Lobe - diagnostic imaging ; Epilepsy, Temporal Lobe - pathology ; Female ; Fluorodeoxyglucose F18 ; Functional Laterality - physiology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampus - diagnostic imaging ; Hippocampus - metabolism ; Hippocampus - physiopathology ; Humans ; Hypometabolism ; Ictal scalp EEG ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Mesial temporal lobe epilepsy ; Nervous system ; Nervous system (semeiology, syndromes) ; Neurology ; PET ; Positron-Emission Tomography - methods ; Retrospective Studies ; Scalp - physiopathology ; Sclerosis - diagnostic imaging ; Sclerosis - etiology ; Sclerosis - pathology ; Young Adult</subject><ispartof>Epilepsy research, 2009-04, Vol.84 (2), p.187-193</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-4e0e0876d48c17237c4e70296b378018b47b009058a1cedf00074e749c07f6843</citedby><cites>FETCH-LOGICAL-c488t-4e0e0876d48c17237c4e70296b378018b47b009058a1cedf00074e749c07f6843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0920121109000357$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21464112$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19285834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Eun Mi</creatorcontrib><creatorcontrib>Im, Ki Chun</creatorcontrib><creatorcontrib>Kim, Ji Hyun</creatorcontrib><creatorcontrib>Lee, Jung Kyo</creatorcontrib><creatorcontrib>Hong, Seok Ho</creatorcontrib><creatorcontrib>No, Young Joo</creatorcontrib><creatorcontrib>Lee, Sang-Ahm</creatorcontrib><creatorcontrib>Kim, Jae Seung</creatorcontrib><creatorcontrib>Kang, Joong Koo</creatorcontrib><title>Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: An FDG–PET study</title><title>Epilepsy research</title><addtitle>Epilepsy Res</addtitle><description>Summary This study was to explore the relationship between scalp ictal EEG patterns and interictal hypometabolic patterns in hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) and determine the clinical significance of interictal hypometabolic patterns. Twenty-five patients were classified into 2 groups based on initial ictal discharge (IID) frequency on scalp EEG: (a) those with a sustained regular 5- to 9-Hz rhythm with a restricted temporal or subtemporal distribution (group 1, N = 9); and (b) those with an irregular 2- to 5-Hz rhythm with a widespread distribution (group 2, N = 16). Using statistical parametric mapping, the PET results of each group were compared with age- and sex-matched controls to identify regions of significant hypometabolism, and the clinical characteristics were compared. Group 1 showed focal hypometabolism confined to the ipsilateral temporal lobe, whereas group 2 showed widespread hypometabolism in the ipsilateral temporal lobe, insular cortex and anterior part of the putamen. The two groups showed no significant differences in clinical characteristics. Among semiologic features, dystonic limb posturing was more frequently observed in group 2 ( p = 0.03). In summary, scalp EEG IID patterns in HS-MTLE can be important in determining hypometabolic patterns on interictal PET. Differences in hypometabolic patterns may reflect preferential pathways of ictal propagation rather than intrinsic epileptogenic regions.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Brain Mapping</subject><subject>Dystonic posture</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Electroencephalography</subject><subject>Epilepsy, Temporal Lobe - complications</subject><subject>Epilepsy, Temporal Lobe - diagnostic imaging</subject><subject>Epilepsy, Temporal Lobe - pathology</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Functional Laterality - physiology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Hypometabolism</subject><subject>Ictal scalp EEG</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesial temporal lobe epilepsy</subject><subject>Nervous system</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>PET</subject><subject>Positron-Emission Tomography - methods</subject><subject>Retrospective Studies</subject><subject>Scalp - physiopathology</subject><subject>Sclerosis - diagnostic imaging</subject><subject>Sclerosis - etiology</subject><subject>Sclerosis - pathology</subject><subject>Young Adult</subject><issn>0920-1211</issn><issn>1872-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksGO0zAQhiMEYsvCKyBf4JYwdtzY4YC0u3QL0kogWM6W40xVl9QJtsMqN56AC2_Ik-DQikpc4GRL_v4Zz_9PlhEKBQVavdgVOHQ4hMljKBhAXQArAJb3sgWVguWV5Px-toCaQU4ZpWfZoxB2ACCA84fZGa2ZXMqSL7LvH7DT0fYubO1AGox3iI5sp6HfY9RN31lDBh0jeheIdi2xJuqOBKO7gaxW69OjdfPdoouB3Nm4JaOzqTT6hKfaQ2_0fvgt7dD3wYaX5MKR69frn99-vF_dkhDHdnqcPdjoLuCT43mefbpe3V69yW_erd9eXdzkhksZc46AIEXVcmmoYKUwHAWwumpKIYHKhosmuQJLqanBdjNPngheGxCbZE55nj0_1B18_2XEENXeBoNdpx32Y1CVoKWsOf0nyIBSuRQygfIAmjRc8LhRg7d77SdFQc2hqZ06habm0BQwlUJL0qfHHmOzx_YkPKaUgGdHQM_Gb7x2xoY_HKO84pSyxF0eOEzWfbXoVTApkOSA9Wiianv7P7959VcR01lnU9_POGHY9aN3KRpFVUgC9XFesnnHkt0A5VKUvwD5WdGp</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Lee, Eun Mi</creator><creator>Im, Ki Chun</creator><creator>Kim, Ji Hyun</creator><creator>Lee, Jung Kyo</creator><creator>Hong, Seok Ho</creator><creator>No, Young Joo</creator><creator>Lee, Sang-Ahm</creator><creator>Kim, Jae Seung</creator><creator>Kang, Joong Koo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: An FDG–PET study</title><author>Lee, Eun Mi ; Im, Ki Chun ; Kim, Ji Hyun ; Lee, Jung Kyo ; Hong, Seok Ho ; No, Young Joo ; Lee, Sang-Ahm ; Kim, Jae Seung ; Kang, Joong Koo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-4e0e0876d48c17237c4e70296b378018b47b009058a1cedf00074e749c07f6843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Brain Mapping</topic><topic>Dystonic posture</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Electroencephalography</topic><topic>Epilepsy, Temporal Lobe - complications</topic><topic>Epilepsy, Temporal Lobe - diagnostic imaging</topic><topic>Epilepsy, Temporal Lobe - pathology</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Functional Laterality - physiology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Hypometabolism</topic><topic>Ictal scalp EEG</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesial temporal lobe epilepsy</topic><topic>Nervous system</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>PET</topic><topic>Positron-Emission Tomography - methods</topic><topic>Retrospective Studies</topic><topic>Scalp - physiopathology</topic><topic>Sclerosis - diagnostic imaging</topic><topic>Sclerosis - etiology</topic><topic>Sclerosis - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Eun Mi</creatorcontrib><creatorcontrib>Im, Ki Chun</creatorcontrib><creatorcontrib>Kim, Ji Hyun</creatorcontrib><creatorcontrib>Lee, Jung Kyo</creatorcontrib><creatorcontrib>Hong, Seok Ho</creatorcontrib><creatorcontrib>No, Young Joo</creatorcontrib><creatorcontrib>Lee, Sang-Ahm</creatorcontrib><creatorcontrib>Kim, Jae Seung</creatorcontrib><creatorcontrib>Kang, Joong Koo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Eun Mi</au><au>Im, Ki Chun</au><au>Kim, Ji Hyun</au><au>Lee, Jung Kyo</au><au>Hong, Seok Ho</au><au>No, Young Joo</au><au>Lee, Sang-Ahm</au><au>Kim, Jae Seung</au><au>Kang, Joong Koo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: An FDG–PET study</atitle><jtitle>Epilepsy research</jtitle><addtitle>Epilepsy Res</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>84</volume><issue>2</issue><spage>187</spage><epage>193</epage><pages>187-193</pages><issn>0920-1211</issn><eissn>1872-6844</eissn><coden>EPIRE8</coden><abstract>Summary This study was to explore the relationship between scalp ictal EEG patterns and interictal hypometabolic patterns in hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) and determine the clinical significance of interictal hypometabolic patterns. Twenty-five patients were classified into 2 groups based on initial ictal discharge (IID) frequency on scalp EEG: (a) those with a sustained regular 5- to 9-Hz rhythm with a restricted temporal or subtemporal distribution (group 1, N = 9); and (b) those with an irregular 2- to 5-Hz rhythm with a widespread distribution (group 2, N = 16). Using statistical parametric mapping, the PET results of each group were compared with age- and sex-matched controls to identify regions of significant hypometabolism, and the clinical characteristics were compared. Group 1 showed focal hypometabolism confined to the ipsilateral temporal lobe, whereas group 2 showed widespread hypometabolism in the ipsilateral temporal lobe, insular cortex and anterior part of the putamen. The two groups showed no significant differences in clinical characteristics. Among semiologic features, dystonic limb posturing was more frequently observed in group 2 ( p = 0.03). In summary, scalp EEG IID patterns in HS-MTLE can be important in determining hypometabolic patterns on interictal PET. Differences in hypometabolic patterns may reflect preferential pathways of ictal propagation rather than intrinsic epileptogenic regions.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>19285834</pmid><doi>10.1016/j.eplepsyres.2009.02.005</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Blood Glucose - metabolism Brain Mapping Dystonic posture Electrodiagnosis. Electric activity recording Electroencephalography Epilepsy, Temporal Lobe - complications Epilepsy, Temporal Lobe - diagnostic imaging Epilepsy, Temporal Lobe - pathology Female Fluorodeoxyglucose F18 Functional Laterality - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - diagnostic imaging Hippocampus - metabolism Hippocampus - physiopathology Humans Hypometabolism Ictal scalp EEG Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Male Medical sciences Mesial temporal lobe epilepsy Nervous system Nervous system (semeiology, syndromes) Neurology PET Positron-Emission Tomography - methods Retrospective Studies Scalp - physiopathology Sclerosis - diagnostic imaging Sclerosis - etiology Sclerosis - pathology Young Adult |
| title | Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: An FDG–PET study |
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