Cancer/testis antigen CT45: Analysis of mRNA and protein expression in human cancer
CT45 is a cancer/testis gene that we previously identified by massively parallel signature sequencing. Encoded by a multigene family on chromosome X, CT45 showed restricted mRNA expression to normal testis and various cancers. In this study, monoclonal antibodies were generated against recombinant C...
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| Veröffentlicht in: | International journal of cancer 2009-06, Vol.124 (12), p.2893-2898 |
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| creator | Chen, Yao‐Tseng Hsu, Melinda Lee, Peishan Shin, Sandra J. Mhawech‐Fauceglia, Paulette Odunsi, Kunle Altorki, Nasser K. Song, Chao‐Jun Jin, Bo‐Quan Simpson, Andrew J. Old, Lloyd J. |
| description | CT45 is a cancer/testis gene that we previously identified by massively parallel signature sequencing. Encoded by a multigene family on chromosome X, CT45 showed restricted mRNA expression to normal testis and various cancers. In this study, monoclonal antibodies were generated against recombinant CT45 protein, and CT45 protein expression in normal and tumor tissues was evaluated by immunohistochemical analysis. In adult normal tissue, CT45 expression was restricted to testicular germ cells, detected as a nuclear protein mainly at the stage of primary spermatocytes. In tumors, CT45 protein expression correlated with the mRNA levels detected by quantitative RT‐PCR, and most lung cancer and ovarian cancers with CT45 mRNA at levels >1% of testicular expression were CT45 protein‐positive. In positive cases, CT45 showed expression patterns that ranged from diffuse strong staining to heterogeneous and patchy expression. In lung cancer, CT45 expression was least frequent in adenocarcinoma, more frequent in squamous cell carcinoma and neuroendocrine tumors. Using tissue microarrays, 376 lung cancer, 219 ovarian cancer and 155 breast cancer were evaluated for CT45 protein expression. The expression frequency was highest in ovarian cancer (37%), followed by lung cancer (13%) and lowest in breast cancer ( |
| doi_str_mv | 10.1002/ijc.24296 |
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Encoded by a multigene family on chromosome X, CT45 showed restricted mRNA expression to normal testis and various cancers. In this study, monoclonal antibodies were generated against recombinant CT45 protein, and CT45 protein expression in normal and tumor tissues was evaluated by immunohistochemical analysis. In adult normal tissue, CT45 expression was restricted to testicular germ cells, detected as a nuclear protein mainly at the stage of primary spermatocytes. In tumors, CT45 protein expression correlated with the mRNA levels detected by quantitative RT‐PCR, and most lung cancer and ovarian cancers with CT45 mRNA at levels >1% of testicular expression were CT45 protein‐positive. In positive cases, CT45 showed expression patterns that ranged from diffuse strong staining to heterogeneous and patchy expression. In lung cancer, CT45 expression was least frequent in adenocarcinoma, more frequent in squamous cell carcinoma and neuroendocrine tumors. Using tissue microarrays, 376 lung cancer, 219 ovarian cancer and 155 breast cancer were evaluated for CT45 protein expression. The expression frequency was highest in ovarian cancer (37%), followed by lung cancer (13%) and lowest in breast cancer (<5%). Given the focal nature of CT45 expression in many cases, these numbers represented the minimal frequency of expression in these tumor types. In summary, the expression frequency and characteristics of CT45 expression are similar to other CT cancer vaccine targets currently in clinical trials, e.g., NY‐ESO‐1 and MAGE‐A, suggesting CT45 as a potentially useful cancer target. © 2009 UICC</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.24296</identifier><identifier>PMID: 19296537</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - secondary ; Animals ; Antibodies, Monoclonal - immunology ; Antibodies, Monoclonal - metabolism ; Antigens, Neoplasm - genetics ; Antigens, Neoplasm - immunology ; Antigens, Neoplasm - metabolism ; Biological and medical sciences ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; cancer vaccine ; cancer/testis antigen ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - secondary ; Female ; Humans ; Lung Neoplasms - genetics ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology ; Prognosis ; Recombinant Proteins - genetics ; Recombinant Proteins - immunology ; Recombinant Proteins - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Testicular Neoplasms - genetics ; Testicular Neoplasms - metabolism ; Testicular Neoplasms - pathology ; Tissue Array Analysis ; tumor antigen ; Tumors</subject><ispartof>International journal of cancer, 2009-06, Vol.124 (12), p.2893-2898</ispartof><rights>Copyright © 2009 UICC</rights><rights>2009 INIST-CNRS</rights><rights>Copyright 2008 UICC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4506-fa95a2a27f26d54dffb384419458100c36b778aa567b6043a7df065b32fcff493</citedby><cites>FETCH-LOGICAL-c4506-fa95a2a27f26d54dffb384419458100c36b778aa567b6043a7df065b32fcff493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.24296$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.24296$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21370922$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19296537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yao‐Tseng</creatorcontrib><creatorcontrib>Hsu, Melinda</creatorcontrib><creatorcontrib>Lee, Peishan</creatorcontrib><creatorcontrib>Shin, Sandra J.</creatorcontrib><creatorcontrib>Mhawech‐Fauceglia, Paulette</creatorcontrib><creatorcontrib>Odunsi, Kunle</creatorcontrib><creatorcontrib>Altorki, Nasser K.</creatorcontrib><creatorcontrib>Song, Chao‐Jun</creatorcontrib><creatorcontrib>Jin, Bo‐Quan</creatorcontrib><creatorcontrib>Simpson, Andrew J.</creatorcontrib><creatorcontrib>Old, Lloyd J.</creatorcontrib><title>Cancer/testis antigen CT45: Analysis of mRNA and protein expression in human cancer</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>CT45 is a cancer/testis gene that we previously identified by massively parallel signature sequencing. Encoded by a multigene family on chromosome X, CT45 showed restricted mRNA expression to normal testis and various cancers. In this study, monoclonal antibodies were generated against recombinant CT45 protein, and CT45 protein expression in normal and tumor tissues was evaluated by immunohistochemical analysis. In adult normal tissue, CT45 expression was restricted to testicular germ cells, detected as a nuclear protein mainly at the stage of primary spermatocytes. In tumors, CT45 protein expression correlated with the mRNA levels detected by quantitative RT‐PCR, and most lung cancer and ovarian cancers with CT45 mRNA at levels >1% of testicular expression were CT45 protein‐positive. In positive cases, CT45 showed expression patterns that ranged from diffuse strong staining to heterogeneous and patchy expression. In lung cancer, CT45 expression was least frequent in adenocarcinoma, more frequent in squamous cell carcinoma and neuroendocrine tumors. Using tissue microarrays, 376 lung cancer, 219 ovarian cancer and 155 breast cancer were evaluated for CT45 protein expression. The expression frequency was highest in ovarian cancer (37%), followed by lung cancer (13%) and lowest in breast cancer (<5%). Given the focal nature of CT45 expression in many cases, these numbers represented the minimal frequency of expression in these tumor types. In summary, the expression frequency and characteristics of CT45 expression are similar to other CT cancer vaccine targets currently in clinical trials, e.g., NY‐ESO‐1 and MAGE‐A, suggesting CT45 as a potentially useful cancer target. © 2009 UICC</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - secondary</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>Antigens, Neoplasm - genetics</subject><subject>Antigens, Neoplasm - immunology</subject><subject>Antigens, Neoplasm - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>cancer vaccine</subject><subject>cancer/testis antigen</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Prognosis</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - immunology</subject><subject>Recombinant Proteins - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Testicular Neoplasms - genetics</subject><subject>Testicular Neoplasms - metabolism</subject><subject>Testicular Neoplasms - pathology</subject><subject>Tissue Array Analysis</subject><subject>tumor antigen</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqWw4AdQNiCxSOu3E3ZVxFMVSFDWkePY4CqPEieC_j1uE8EKsRrNzNGduReAUwSnCEI8sys1xRTHfA-MEYxFCDFi-2DsdzAUiPAROHJuBSFCDNJDMEKxhxkRY_CSyErpZtZq11oXyKq1b7oKkiVlV8G8ksXG-XFtgvL5ce7XebBu6lbbKtBf60Y7Z-sq8N17V8oqUDuxY3BgZOH0yVAn4PXmepnchYun2_tkvggVZZCHRsZMYomFwTxnNDcmIxGlKKYs8rYU4ZkQkZSMi4xDSqTIDeQsI9goY2hMJuCi1_UvfXTeQFpap3RRyErXnUu5ty5I9D-IEcKQkC142YOqqZ1rtEnXjS1ls0kRTLdRpz7qdBe1Z88G0S4rdf5LDtl64HwApFOyMI0Px7ofDvvnYIyx52Y992kLvfn7Ynr_kPSnvwGFnpMN</recordid><startdate>20090615</startdate><enddate>20090615</enddate><creator>Chen, Yao‐Tseng</creator><creator>Hsu, Melinda</creator><creator>Lee, Peishan</creator><creator>Shin, Sandra J.</creator><creator>Mhawech‐Fauceglia, Paulette</creator><creator>Odunsi, Kunle</creator><creator>Altorki, Nasser K.</creator><creator>Song, Chao‐Jun</creator><creator>Jin, Bo‐Quan</creator><creator>Simpson, Andrew J.</creator><creator>Old, Lloyd J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20090615</creationdate><title>Cancer/testis antigen CT45: Analysis of mRNA and protein expression in human cancer</title><author>Chen, Yao‐Tseng ; Hsu, Melinda ; Lee, Peishan ; Shin, Sandra J. ; Mhawech‐Fauceglia, Paulette ; Odunsi, Kunle ; Altorki, Nasser K. ; Song, Chao‐Jun ; Jin, Bo‐Quan ; Simpson, Andrew J. ; Old, Lloyd J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4506-fa95a2a27f26d54dffb384419458100c36b778aa567b6043a7df065b32fcff493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - secondary</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibodies, Monoclonal - metabolism</topic><topic>Antigens, Neoplasm - genetics</topic><topic>Antigens, Neoplasm - immunology</topic><topic>Antigens, Neoplasm - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>cancer vaccine</topic><topic>cancer/testis antigen</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Prognosis</topic><topic>Recombinant Proteins - genetics</topic><topic>Recombinant Proteins - immunology</topic><topic>Recombinant Proteins - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Testicular Neoplasms - genetics</topic><topic>Testicular Neoplasms - metabolism</topic><topic>Testicular Neoplasms - pathology</topic><topic>Tissue Array Analysis</topic><topic>tumor antigen</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yao‐Tseng</creatorcontrib><creatorcontrib>Hsu, Melinda</creatorcontrib><creatorcontrib>Lee, Peishan</creatorcontrib><creatorcontrib>Shin, Sandra J.</creatorcontrib><creatorcontrib>Mhawech‐Fauceglia, Paulette</creatorcontrib><creatorcontrib>Odunsi, Kunle</creatorcontrib><creatorcontrib>Altorki, Nasser K.</creatorcontrib><creatorcontrib>Song, Chao‐Jun</creatorcontrib><creatorcontrib>Jin, Bo‐Quan</creatorcontrib><creatorcontrib>Simpson, Andrew J.</creatorcontrib><creatorcontrib>Old, Lloyd J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yao‐Tseng</au><au>Hsu, Melinda</au><au>Lee, Peishan</au><au>Shin, Sandra J.</au><au>Mhawech‐Fauceglia, Paulette</au><au>Odunsi, Kunle</au><au>Altorki, Nasser K.</au><au>Song, Chao‐Jun</au><au>Jin, Bo‐Quan</au><au>Simpson, Andrew J.</au><au>Old, Lloyd J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer/testis antigen CT45: Analysis of mRNA and protein expression in human cancer</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2009-06-15</date><risdate>2009</risdate><volume>124</volume><issue>12</issue><spage>2893</spage><epage>2898</epage><pages>2893-2898</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>CT45 is a cancer/testis gene that we previously identified by massively parallel signature sequencing. Encoded by a multigene family on chromosome X, CT45 showed restricted mRNA expression to normal testis and various cancers. In this study, monoclonal antibodies were generated against recombinant CT45 protein, and CT45 protein expression in normal and tumor tissues was evaluated by immunohistochemical analysis. In adult normal tissue, CT45 expression was restricted to testicular germ cells, detected as a nuclear protein mainly at the stage of primary spermatocytes. In tumors, CT45 protein expression correlated with the mRNA levels detected by quantitative RT‐PCR, and most lung cancer and ovarian cancers with CT45 mRNA at levels >1% of testicular expression were CT45 protein‐positive. In positive cases, CT45 showed expression patterns that ranged from diffuse strong staining to heterogeneous and patchy expression. In lung cancer, CT45 expression was least frequent in adenocarcinoma, more frequent in squamous cell carcinoma and neuroendocrine tumors. Using tissue microarrays, 376 lung cancer, 219 ovarian cancer and 155 breast cancer were evaluated for CT45 protein expression. The expression frequency was highest in ovarian cancer (37%), followed by lung cancer (13%) and lowest in breast cancer (<5%). Given the focal nature of CT45 expression in many cases, these numbers represented the minimal frequency of expression in these tumor types. In summary, the expression frequency and characteristics of CT45 expression are similar to other CT cancer vaccine targets currently in clinical trials, e.g., NY‐ESO‐1 and MAGE‐A, suggesting CT45 as a potentially useful cancer target. © 2009 UICC</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19296537</pmid><doi>10.1002/ijc.24296</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - secondary Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology cancer vaccine cancer/testis antigen Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - secondary Female Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical sciences Mice Mice, Inbred BALB C Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Prognosis Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Testicular Neoplasms - genetics Testicular Neoplasms - metabolism Testicular Neoplasms - pathology Tissue Array Analysis tumor antigen Tumors |
| title | Cancer/testis antigen CT45: Analysis of mRNA and protein expression in human cancer |
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