Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes
A subset of CD8(+) T cells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8(+) T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a diff...
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| Veröffentlicht in: | European journal of immunology 2004-12, Vol.34 (12), p.3456-3464 |
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| container_title | European journal of immunology |
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| creator | Arlettaz, Lionel Villard, Jean de Rham, Casimir Degermann, Sylvie Chapuis, Bernard Huard, Bertrand Roosnek, Eddy |
| description | A subset of CD8(+) T cells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8(+) T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a different subset consisting of CCR7(+) memory cells and CCR7(-) effector cells. Since NKG2A can only be induced on naive CD8(+) T cells while CD94(-) memory cells are refractory, it is likely that commitment to the CD94:NKG2A(+) subset occurs during the first encounter with antigen. CCR7(+)CD94:NKG2A(+) T cells recirculate through lymph nodes where upon activation, they produce large quantities of IFN-gamma. These cells occur as a separate CD94:NKG2A(+) T cell lineage with a distinct TCR repertoire that differs from that of the other CD8(+)CD94(-) T cells activated in situ. |
| format | Article |
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We found that although many CD8(+) T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a different subset consisting of CCR7(+) memory cells and CCR7(-) effector cells. Since NKG2A can only be induced on naive CD8(+) T cells while CD94(-) memory cells are refractory, it is likely that commitment to the CD94:NKG2A(+) subset occurs during the first encounter with antigen. CCR7(+)CD94:NKG2A(+) T cells recirculate through lymph nodes where upon activation, they produce large quantities of IFN-gamma. 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We found that although many CD8(+) T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a different subset consisting of CCR7(+) memory cells and CCR7(-) effector cells. Since NKG2A can only be induced on naive CD8(+) T cells while CD94(-) memory cells are refractory, it is likely that commitment to the CD94:NKG2A(+) subset occurs during the first encounter with antigen. CCR7(+)CD94:NKG2A(+) T cells recirculate through lymph nodes where upon activation, they produce large quantities of IFN-gamma. These cells occur as a separate CD94:NKG2A(+) T cell lineage with a distinct TCR repertoire that differs from that of the other CD8(+)CD94(-) T cells activated in situ.</description><subject>Antigens, CD - immunology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Humans</subject><subject>Immunologic Memory - immunology</subject><subject>Interferon-gamma - metabolism</subject><subject>Lectins, C-Type - immunology</subject><subject>NK Cell Lectin-Like Receptor Subfamily C</subject><subject>NK Cell Lectin-Like Receptor Subfamily D</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>Receptors, Immunologic - immunology</subject><subject>Receptors, Natural Killer Cell</subject><subject>T-Lymphocyte Subsets - immunology</subject><issn>0014-2980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhntQ3HX1L0hOXqSQtknaeFu6uoqLguy9TJKpG-lHbFKxv8C_bcEV5_LCvA8PzJxES0oTFqeyoIvo3Pt3SqkUXJ5Fi4TzJBdJuoy-1zrYTwi2eyPlRrLb56dtWhLoDLHdwSob-mH6b9ZkQI1uXnoCAxL8cgN6j4aoiRjrZ48OxI_KY_Ckr4nu29aGMAPlprgh-_KVQOMOoDAAaabWHXo9BfQX0WkNjcfLY66i_f3dvnyIdy_bx3K9ix1naQySMS7qRKQFSlCFkRKBC15rLRjoAqQ0qlYyL3KmuKn5PIBMUYFKz0dnq-j6V-uG_mNEH6rWeo1NAx32o69EnmQip2wGr47gqFo0lRtsC8NU_X0u-wEKFGl1</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Arlettaz, Lionel</creator><creator>Villard, Jean</creator><creator>de Rham, Casimir</creator><creator>Degermann, Sylvie</creator><creator>Chapuis, Bernard</creator><creator>Huard, Bertrand</creator><creator>Roosnek, Eddy</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200412</creationdate><title>Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes</title><author>Arlettaz, Lionel ; Villard, Jean ; de Rham, Casimir ; Degermann, Sylvie ; Chapuis, Bernard ; Huard, Bertrand ; Roosnek, Eddy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p542-a94456f1628e9ab8d99ea565fcc64ac8a99dbfb97874b5df5555ae4b06ebc1553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antigens, CD - immunology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>Humans</topic><topic>Immunologic Memory - immunology</topic><topic>Interferon-gamma - metabolism</topic><topic>Lectins, C-Type - immunology</topic><topic>NK Cell Lectin-Like Receptor Subfamily C</topic><topic>NK Cell Lectin-Like Receptor Subfamily D</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>Receptors, Immunologic - immunology</topic><topic>Receptors, Natural Killer Cell</topic><topic>T-Lymphocyte Subsets - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arlettaz, Lionel</creatorcontrib><creatorcontrib>Villard, Jean</creatorcontrib><creatorcontrib>de Rham, Casimir</creatorcontrib><creatorcontrib>Degermann, Sylvie</creatorcontrib><creatorcontrib>Chapuis, Bernard</creatorcontrib><creatorcontrib>Huard, Bertrand</creatorcontrib><creatorcontrib>Roosnek, Eddy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arlettaz, Lionel</au><au>Villard, Jean</au><au>de Rham, Casimir</au><au>Degermann, Sylvie</au><au>Chapuis, Bernard</au><au>Huard, Bertrand</au><au>Roosnek, Eddy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>2004-12</date><risdate>2004</risdate><volume>34</volume><issue>12</issue><spage>3456</spage><epage>3464</epage><pages>3456-3464</pages><issn>0014-2980</issn><abstract>A subset of CD8(+) T cells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8(+) T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a different subset consisting of CCR7(+) memory cells and CCR7(-) effector cells. Since NKG2A can only be induced on naive CD8(+) T cells while CD94(-) memory cells are refractory, it is likely that commitment to the CD94:NKG2A(+) subset occurs during the first encounter with antigen. CCR7(+)CD94:NKG2A(+) T cells recirculate through lymph nodes where upon activation, they produce large quantities of IFN-gamma. These cells occur as a separate CD94:NKG2A(+) T cell lineage with a distinct TCR repertoire that differs from that of the other CD8(+)CD94(-) T cells activated in situ.</abstract><cop>Germany</cop><pmid>15517612</pmid><tpages>9</tpages></addata></record> |
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| ispartof | European journal of immunology, 2004-12, Vol.34 (12), p.3456-3464 |
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| language | eng |
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| source | MEDLINE; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals |
| subjects | Antigens, CD - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Humans Immunologic Memory - immunology Interferon-gamma - metabolism Lectins, C-Type - immunology NK Cell Lectin-Like Receptor Subfamily C NK Cell Lectin-Like Receptor Subfamily D Receptors, Antigen, T-Cell - immunology Receptors, Immunologic - immunology Receptors, Natural Killer Cell T-Lymphocyte Subsets - immunology |
| title | Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes |
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