Effect of surface structure on protein adsorption to biphasic calcium-phosphate ceramics in vitro and in vivo
Protein adsorption affects the function of cells and determines the bioactivity of biomaterial implants. Surface structure and properties of materials determine the behavior of protein adsorption. In the present study, two biphasic calcium-phosphate ceramics (BCPs) with different surface structures...
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| Veröffentlicht in: | Acta biomaterialia 2009-05, Vol.5 (4), p.1311-1318 |
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| container_title | Acta biomaterialia |
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| creator | Zhu, X.D. Fan, H.S. Xiao, Y.M. Li, D.X. Zhang, H.J. Luxbacher, T. Zhang, X.D. |
| description | Protein adsorption affects the function of cells and determines the bioactivity of biomaterial implants. Surface structure and properties of materials determine the behavior of protein adsorption. In the present study, two biphasic calcium-phosphate ceramics (BCPs) with different surface structures were fabricated by pressing and H
2O
2 foaming methods. Their surface characteristics were analyzed and the in vitro and in vivo protein adsorption on them was investigated. Porous BCP showed higher ability to adsorb proteins, and transforming growth factor-β1 (TGF-β1) adsorption notably increased with increasing in vivo implantation time. The strong affinity of BCP to TGF-β1 might provide important information for exploring the mechanism of the osteoinduction of calcium phosphates. |
| doi_str_mv | 10.1016/j.actbio.2008.11.024 |
| format | Article |
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2O
2 foaming methods. Their surface characteristics were analyzed and the in vitro and in vivo protein adsorption on them was investigated. Porous BCP showed higher ability to adsorb proteins, and transforming growth factor-β1 (TGF-β1) adsorption notably increased with increasing in vivo implantation time. The strong affinity of BCP to TGF-β1 might provide important information for exploring the mechanism of the osteoinduction of calcium phosphates.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2008.11.024</identifier><identifier>PMID: 19121984</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adsorption ; Animals ; BCPs ; Calcium Phosphates - chemistry ; Ceramics - chemistry ; Microscopy, Electron, Scanning ; Protein adsorption ; Rats ; Rats, Sprague-Dawley ; Surface structure ; TGF-β1 ; Transforming Growth Factor beta - chemistry ; X-Ray Diffraction</subject><ispartof>Acta biomaterialia, 2009-05, Vol.5 (4), p.1311-1318</ispartof><rights>2008 Acta Materialia Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-d3769aef2aeced2e8369b15c51e397531f93b3f7252bb7e3405ac35c9533715a3</citedby><cites>FETCH-LOGICAL-c539t-d3769aef2aeced2e8369b15c51e397531f93b3f7252bb7e3405ac35c9533715a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actbio.2008.11.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19121984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, X.D.</creatorcontrib><creatorcontrib>Fan, H.S.</creatorcontrib><creatorcontrib>Xiao, Y.M.</creatorcontrib><creatorcontrib>Li, D.X.</creatorcontrib><creatorcontrib>Zhang, H.J.</creatorcontrib><creatorcontrib>Luxbacher, T.</creatorcontrib><creatorcontrib>Zhang, X.D.</creatorcontrib><title>Effect of surface structure on protein adsorption to biphasic calcium-phosphate ceramics in vitro and in vivo</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>Protein adsorption affects the function of cells and determines the bioactivity of biomaterial implants. Surface structure and properties of materials determine the behavior of protein adsorption. In the present study, two biphasic calcium-phosphate ceramics (BCPs) with different surface structures were fabricated by pressing and H
2O
2 foaming methods. Their surface characteristics were analyzed and the in vitro and in vivo protein adsorption on them was investigated. Porous BCP showed higher ability to adsorb proteins, and transforming growth factor-β1 (TGF-β1) adsorption notably increased with increasing in vivo implantation time. The strong affinity of BCP to TGF-β1 might provide important information for exploring the mechanism of the osteoinduction of calcium phosphates.</description><subject>Adsorption</subject><subject>Animals</subject><subject>BCPs</subject><subject>Calcium Phosphates - chemistry</subject><subject>Ceramics - chemistry</subject><subject>Microscopy, Electron, Scanning</subject><subject>Protein adsorption</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Surface structure</subject><subject>TGF-β1</subject><subject>Transforming Growth Factor beta - chemistry</subject><subject>X-Ray Diffraction</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrHSEQx6U0NGnSb1CKp9526-i6updCCUlbCPSSnMV1R-Lj7bpV90G_fQ37oLfmpA6_mZH_j5CPwFpg0H85tNaVMcSWM6ZbgJbx7g25Aq10o2Sv39a76nijWA-X5H3OB8aEBq7fkUsYgMOguysy33mPrtDoad6Stw5pLmlzZUtI40LXFAuGhdopx7SWUEsl0jGszzYHR509urDNzfoccy0VpA6TnYPLtDadQkmR2mXaH6d4Qy68PWb8cD6vydP93ePtj-bh1_eft98eGifFUJpJqH6w6LlFhxNHLfphBOkkoBiUFOAHMQqvuOTjqFB0TFonpBukEAqkFdfk8z63fv_3hrmYOWSHx6NdMG7Z9ApE34N-FRRdTXfo-KsgZ5J3vBMV7HbQpZhzQm_WFGab_hhg5kWcOZhdnHkRZwBMFVfbPp3nb-OM07-ms6kKfN0BrLmdAiaTXcCl5hNSFWimGP6_4S-7OKxa</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Zhu, X.D.</creator><creator>Fan, H.S.</creator><creator>Xiao, Y.M.</creator><creator>Li, D.X.</creator><creator>Zhang, H.J.</creator><creator>Luxbacher, T.</creator><creator>Zhang, X.D.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Effect of surface structure on protein adsorption to biphasic calcium-phosphate ceramics in vitro and in vivo</title><author>Zhu, X.D. ; Fan, H.S. ; Xiao, Y.M. ; Li, D.X. ; Zhang, H.J. ; Luxbacher, T. ; Zhang, X.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-d3769aef2aeced2e8369b15c51e397531f93b3f7252bb7e3405ac35c9533715a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adsorption</topic><topic>Animals</topic><topic>BCPs</topic><topic>Calcium Phosphates - chemistry</topic><topic>Ceramics - chemistry</topic><topic>Microscopy, Electron, Scanning</topic><topic>Protein adsorption</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Surface structure</topic><topic>TGF-β1</topic><topic>Transforming Growth Factor beta - chemistry</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, X.D.</creatorcontrib><creatorcontrib>Fan, H.S.</creatorcontrib><creatorcontrib>Xiao, Y.M.</creatorcontrib><creatorcontrib>Li, D.X.</creatorcontrib><creatorcontrib>Zhang, H.J.</creatorcontrib><creatorcontrib>Luxbacher, T.</creatorcontrib><creatorcontrib>Zhang, X.D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, X.D.</au><au>Fan, H.S.</au><au>Xiao, Y.M.</au><au>Li, D.X.</au><au>Zhang, H.J.</au><au>Luxbacher, T.</au><au>Zhang, X.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of surface structure on protein adsorption to biphasic calcium-phosphate ceramics in vitro and in vivo</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>5</volume><issue>4</issue><spage>1311</spage><epage>1318</epage><pages>1311-1318</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>Protein adsorption affects the function of cells and determines the bioactivity of biomaterial implants. Surface structure and properties of materials determine the behavior of protein adsorption. In the present study, two biphasic calcium-phosphate ceramics (BCPs) with different surface structures were fabricated by pressing and H
2O
2 foaming methods. Their surface characteristics were analyzed and the in vitro and in vivo protein adsorption on them was investigated. Porous BCP showed higher ability to adsorb proteins, and transforming growth factor-β1 (TGF-β1) adsorption notably increased with increasing in vivo implantation time. The strong affinity of BCP to TGF-β1 might provide important information for exploring the mechanism of the osteoinduction of calcium phosphates.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19121984</pmid><doi>10.1016/j.actbio.2008.11.024</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Acta biomaterialia, 2009-05, Vol.5 (4), p.1311-1318 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adsorption Animals BCPs Calcium Phosphates - chemistry Ceramics - chemistry Microscopy, Electron, Scanning Protein adsorption Rats Rats, Sprague-Dawley Surface structure TGF-β1 Transforming Growth Factor beta - chemistry X-Ray Diffraction |
| title | Effect of surface structure on protein adsorption to biphasic calcium-phosphate ceramics in vitro and in vivo |
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