Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications
Injectable acrylamide/ N-vinylpyrrolidinone copolymers with pendent thiol groups were prepared by a radical polymerization and reductive dissolution reaction. The solution of copolymers was re-gelled through oxidation in air or the thiol–disulfide exchange reaction. The re-gelation time could be adj...
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| Veröffentlicht in: | Acta biomaterialia 2009-05, Vol.5 (4), p.1056-1063 |
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| container_title | Acta biomaterialia |
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| creator | Niu, Guoguang Yang, Ying Zhang, Hongbin Yang, Jun Song, Li Kashima, Miki Yang, Zhou Cao, Hui Zheng, Yudong Zhu, Siquan Yang, Huai |
| description | Injectable acrylamide/
N-vinylpyrrolidinone copolymers with pendent thiol groups were prepared by a radical polymerization and reductive dissolution reaction. The solution of copolymers was re-gelled through oxidation in air or the thiol–disulfide exchange reaction. The re-gelation time could be adjusted from several minutes to several hours by changing the amount of the disulfide exchange reagent. The re-gelled hydrogels possessed high transmittance in the visible region but could block out some of the ultraviolet radiation. Their refractive indexes ranged from 1.34 to 1.35, and their equilibrium water contents were over 95.0%. The morphologies of the hydrogels were analyzed and the porous structure, with pore sizes of 50–300
μm, was noted. The cytotoxicities of the hydrogels were clearly reduced compared with previous results. The experimental results indicated that the injectable copolymers could be used as an artificial vitreous substance or as a scaffold for lens regeneration. |
| doi_str_mv | 10.1016/j.actbio.2008.10.015 |
| format | Article |
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N-vinylpyrrolidinone copolymers with pendent thiol groups were prepared by a radical polymerization and reductive dissolution reaction. The solution of copolymers was re-gelled through oxidation in air or the thiol–disulfide exchange reaction. The re-gelation time could be adjusted from several minutes to several hours by changing the amount of the disulfide exchange reagent. The re-gelled hydrogels possessed high transmittance in the visible region but could block out some of the ultraviolet radiation. Their refractive indexes ranged from 1.34 to 1.35, and their equilibrium water contents were over 95.0%. The morphologies of the hydrogels were analyzed and the porous structure, with pore sizes of 50–300
μm, was noted. The cytotoxicities of the hydrogels were clearly reduced compared with previous results. The experimental results indicated that the injectable copolymers could be used as an artificial vitreous substance or as a scaffold for lens regeneration.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2008.10.015</identifier><identifier>PMID: 19070556</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acrylamide - chemistry ; Disulfide bond ; Disulfides - chemistry ; Eye ; Hydrogel ; Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry ; Hydrogen-Ion Concentration ; Lens regeneration ; Microscopy, Electron, Scanning ; Molecular Structure ; Polymers - chemical synthesis ; Polymers - chemistry ; Pyrrolidinones - chemistry ; Solutions ; Spectrum Analysis, Raman ; Sulfhydryl Compounds - chemistry ; Vitreous substance</subject><ispartof>Acta biomaterialia, 2009-05, Vol.5 (4), p.1056-1063</ispartof><rights>2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-b8218756f7b7d9b11bf12d01995cf7b051c4347462f5aae588e3a68f33f4a6533</citedby><cites>FETCH-LOGICAL-c422t-b8218756f7b7d9b11bf12d01995cf7b051c4347462f5aae588e3a68f33f4a6533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706108003292$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19070556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niu, Guoguang</creatorcontrib><creatorcontrib>Yang, Ying</creatorcontrib><creatorcontrib>Zhang, Hongbin</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><creatorcontrib>Song, Li</creatorcontrib><creatorcontrib>Kashima, Miki</creatorcontrib><creatorcontrib>Yang, Zhou</creatorcontrib><creatorcontrib>Cao, Hui</creatorcontrib><creatorcontrib>Zheng, Yudong</creatorcontrib><creatorcontrib>Zhu, Siquan</creatorcontrib><creatorcontrib>Yang, Huai</creatorcontrib><title>Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>Injectable acrylamide/
N-vinylpyrrolidinone copolymers with pendent thiol groups were prepared by a radical polymerization and reductive dissolution reaction. The solution of copolymers was re-gelled through oxidation in air or the thiol–disulfide exchange reaction. The re-gelation time could be adjusted from several minutes to several hours by changing the amount of the disulfide exchange reagent. The re-gelled hydrogels possessed high transmittance in the visible region but could block out some of the ultraviolet radiation. Their refractive indexes ranged from 1.34 to 1.35, and their equilibrium water contents were over 95.0%. The morphologies of the hydrogels were analyzed and the porous structure, with pore sizes of 50–300
μm, was noted. The cytotoxicities of the hydrogels were clearly reduced compared with previous results. The experimental results indicated that the injectable copolymers could be used as an artificial vitreous substance or as a scaffold for lens regeneration.</description><subject>Acrylamide - chemistry</subject><subject>Disulfide bond</subject><subject>Disulfides - chemistry</subject><subject>Eye</subject><subject>Hydrogel</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Lens regeneration</subject><subject>Microscopy, Electron, Scanning</subject><subject>Molecular Structure</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - chemistry</subject><subject>Pyrrolidinones - chemistry</subject><subject>Solutions</subject><subject>Spectrum Analysis, Raman</subject><subject>Sulfhydryl Compounds - chemistry</subject><subject>Vitreous substance</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhosozjj6D0Syctc7-U66EWTwCwZdqOuQpic2l7SpSe5I3fjX7Z17wZ2zSnh5zntInqZ5SfCOYCKv9zvrah_SjmKst2iHiXjUXBKtdKuE1I-3u-K0VViSi-ZZKXuMmSZUP20uSIcVFkJeNn--rnMdoYSC7DwgN9q81UIOv20NaUbJI-vyGu0UBrj-3N6FeY3LmnOKYUgzIJeWFNcJMvoV6ogWmAeYK6pjSBH9yOmwFORTRmkZ62jjFByyyxKDu-8vz5sn3sYCL87nVfP9_btvNx_b2y8fPt28vW0dp7S2vabbw4T0qldD1xPSe0IHTLpOuC3DgjjOuOKSemEtCK2BWak9Y55bKRi7al6fepecfh6gVDOF4iBGO0M6FCMVYUJ13YMg40wRSdSDIMWCcnq_mp9Al1MpGbxZcphsXg3B5qjS7M1JpTmqPKabym3s1bn_0E8w_Bs6u9uANycAtn-7C5BNcQFmB0PI4KoZUvj_hr84eLRh</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Niu, Guoguang</creator><creator>Yang, Ying</creator><creator>Zhang, Hongbin</creator><creator>Yang, Jun</creator><creator>Song, Li</creator><creator>Kashima, Miki</creator><creator>Yang, Zhou</creator><creator>Cao, Hui</creator><creator>Zheng, Yudong</creator><creator>Zhu, Siquan</creator><creator>Yang, Huai</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications</title><author>Niu, Guoguang ; 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N-vinylpyrrolidinone copolymers with pendent thiol groups were prepared by a radical polymerization and reductive dissolution reaction. The solution of copolymers was re-gelled through oxidation in air or the thiol–disulfide exchange reaction. The re-gelation time could be adjusted from several minutes to several hours by changing the amount of the disulfide exchange reagent. The re-gelled hydrogels possessed high transmittance in the visible region but could block out some of the ultraviolet radiation. Their refractive indexes ranged from 1.34 to 1.35, and their equilibrium water contents were over 95.0%. The morphologies of the hydrogels were analyzed and the porous structure, with pore sizes of 50–300
μm, was noted. The cytotoxicities of the hydrogels were clearly reduced compared with previous results. The experimental results indicated that the injectable copolymers could be used as an artificial vitreous substance or as a scaffold for lens regeneration.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19070556</pmid><doi>10.1016/j.actbio.2008.10.015</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acrylamide - chemistry Disulfide bond Disulfides - chemistry Eye Hydrogel Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogen-Ion Concentration Lens regeneration Microscopy, Electron, Scanning Molecular Structure Polymers - chemical synthesis Polymers - chemistry Pyrrolidinones - chemistry Solutions Spectrum Analysis, Raman Sulfhydryl Compounds - chemistry Vitreous substance |
| title | Synthesis and characterization of acrylamide/N-vinylpyrrolidone copolymer with pendent thiol groups for ophthalmic applications |
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