Intraocular injection of tamoxifen‐loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis

In this study, we tested the efficiency of an intravitreal injection of tamoxifen, a non‐steroidal estrogen receptor modulator, in retinal soluble antigen (S‐Ag)‐induced experimental autoimmune uveoretinitis (EAU). To increase the bioavailability of tamoxifen, we incorporated tamoxifen into polyethy...

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Veröffentlicht in:	European journal of immunology 2004-12, Vol.34 (12), p.3702-3712
Hauptverfasser:	de Kozak, Yvonne, Andrieux, Karine, Villarroya, Henri, Klein, Christophe, Thillaye‐Goldenberg, Brigitte, Naud, Marie‐Christine, Garcia, Elisabeth, Couvreur, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - metabolism Drug delivery Experimental autoimmune uveoretinitis Immunohistochemistry Injections Nanoparticles Nanotubes Rats Retina - immunology Retina - metabolism Retinitis - drug therapy Selective Estrogen Receptor Modulators - administration & dosage Selective Estrogen Receptor Modulators - therapeutic use Tamoxifen Tamoxifen - administration & dosage Tamoxifen - therapeutic use Time Factors Treatment Uvea - immunology Uvea - metabolism Uveitis - drug therapy
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