Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients
Vascular dysfunction in hypertensive condition is characterized by impaired endothelial function and reduced artery elasticity. Circulating endothelial microparticles (EMPs) and brachial–ankle pulse wave velocity (baPWV) are novel evaluation parameters for vascular function. However, their changes i...
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| Veröffentlicht in: | Journal of human hypertension 2009-05, Vol.23 (5), p.307-315 |
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| creator | Wang, J-M Su, C Wang, Y Huang, Y-J Yang, Z Chen, L Wu, F Xu, S-Y Tao, J |
| description | Vascular dysfunction in hypertensive condition is characterized by impaired endothelial function and reduced artery elasticity. Circulating endothelial microparticles (EMPs) and brachial–ankle pulse wave velocity (baPWV) are novel evaluation parameters for vascular function. However, their changes in patients with well-controlled blood pressure (BP) have not been fully acquired. To address this issue, circulating EMPs, defined as CD31+/CD42− MPs and baPWV were detected in 30 healthy subjects, 30 uncontrolled hypertensive (UCHT) patients and 23 well-controlled hypertensive (WCHT) patients. UCHT patients displayed elevated baPWV (
P |
| doi_str_mv | 10.1038/jhh.2008.137 |
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P
<0.01) and circulating EMPs (
P
<0.01) compared with healthy subjects. In WCHT patients, vascular damage represented by these two parameters constantly existed (
P
<0.01). Values of circulating EMPs were positively related to baPWV (
P
<0.01). Multivariate regression defined circulating EMPs as an independent contributor to the increase of baPWV value (
P
<0.05). Our study indicated that though BP was controlled, impaired endothelial function and arterial elasticity continued. The optimal therapy for patients with hypertension should include not only lowering BP but also improvement of vascular injury in parallel.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/jhh.2008.137</identifier><identifier>PMID: 19037229</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Ankle ; Ankle Brachial Index - methods ; Antihypertensive agents ; Antihypertensive drugs ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Blood pressure ; Cardiology. Vascular system ; Cardiovascular diseases ; Cardiovascular system ; Case-Control Studies ; Cell-Derived Microparticles - metabolism ; Cross-Sectional Studies ; Diagnosis ; Drug therapy ; Elasticity ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - physiopathology ; Epidemiology ; Female ; Flow Cytometry ; Health Administration ; Health aspects ; Humans ; Hypertension ; Hypertension - diagnosis ; Hypertension - physiopathology ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Microparticles ; Middle Aged ; original-article ; Pharmacology. Drug treatments ; Platelet Endothelial Cell Adhesion Molecule-1 - blood ; Platelet Glycoprotein GPIb-IX Complex - metabolism ; Plethysmography - methods ; Public Health ; Risk factors ; Velocity</subject><ispartof>Journal of human hypertension, 2009-05, Vol.23 (5), p.307-315</ispartof><rights>Macmillan Publishers Limited 2009</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2009</rights><rights>Macmillan Publishers Limited 2009.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-b340bf3925ca7005cdef9aec9c61ecde395b9c939de879da47adff0d61fc79e33</citedby><cites>FETCH-LOGICAL-c576t-b340bf3925ca7005cdef9aec9c61ecde395b9c939de879da47adff0d61fc79e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jhh.2008.137$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jhh.2008.137$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21324871$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19037229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, J-M</creatorcontrib><creatorcontrib>Su, C</creatorcontrib><creatorcontrib>Wang, Y</creatorcontrib><creatorcontrib>Huang, Y-J</creatorcontrib><creatorcontrib>Yang, Z</creatorcontrib><creatorcontrib>Chen, L</creatorcontrib><creatorcontrib>Wu, F</creatorcontrib><creatorcontrib>Xu, S-Y</creatorcontrib><creatorcontrib>Tao, J</creatorcontrib><title>Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Vascular dysfunction in hypertensive condition is characterized by impaired endothelial function and reduced artery elasticity. Circulating endothelial microparticles (EMPs) and brachial–ankle pulse wave velocity (baPWV) are novel evaluation parameters for vascular function. However, their changes in patients with well-controlled blood pressure (BP) have not been fully acquired. To address this issue, circulating EMPs, defined as CD31+/CD42− MPs and baPWV were detected in 30 healthy subjects, 30 uncontrolled hypertensive (UCHT) patients and 23 well-controlled hypertensive (WCHT) patients. UCHT patients displayed elevated baPWV (
P
<0.01) and circulating EMPs (
P
<0.01) compared with healthy subjects. In WCHT patients, vascular damage represented by these two parameters constantly existed (
P
<0.01). Values of circulating EMPs were positively related to baPWV (
P
<0.01). Multivariate regression defined circulating EMPs as an independent contributor to the increase of baPWV value (
P
<0.05). Our study indicated that though BP was controlled, impaired endothelial function and arterial elasticity continued. The optimal therapy for patients with hypertension should include not only lowering BP but also improvement of vascular injury in parallel.</description><subject>Ankle</subject><subject>Ankle Brachial Index - methods</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive drugs</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular system</subject><subject>Case-Control Studies</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Diagnosis</subject><subject>Drug therapy</subject><subject>Elasticity</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Health Administration</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microparticles</subject><subject>Middle Aged</subject><subject>original-article</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - blood</subject><subject>Platelet Glycoprotein GPIb-IX Complex - metabolism</subject><subject>Plethysmography - methods</subject><subject>Public Health</subject><subject>Risk factors</subject><subject>Velocity</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1ksuO0zAUhiMEYsrAjjWKQMyKFDtO4ng5Gg0XaSQ2sLZc56Rxce1gOx11B8_AG_IknKgVZdAgLyz7fOfi33-WPadkSQlr326GYVkS0i4p4w-yBa14U9R1yR9mCyJqUoiyImfZkxg3hMzB9nF2RgVhvCzFIvtxbWGnEnS5NkFPViXj1jm4zqcBrFE23xod_KhCMtpCzJXr8lVQesDYr-8_lftqIR8nGyG_VTvId2C9NmmfG5ffgrWF9i4Fby22GPYjhAQuGgRHbAUuxafZo15h-rPjfp59eXf9-epDcfPp_cery5tC17xJxYpVZNUzUdZacUJq3UEvFGihGwp4YKJeCS2Y6KDlolMVV13fk66hveYCGDvPLg51x-C_TRCT3JqocULlwE9RNpwyJohA8NU_4MZPweFssmwqUrctLylSL_9LUSGahlblqdRaWZDG9T6hdHNfeUlFW1dctPNky3soXB2g-N5Bb_D-TsLFXwkDKJuG6O2UjHfxLvjmAOIXxhigl2MwWxX2khI5u0eie-TsHonuQfzF8U3TagvdCT7aBYHXR0BFrWwflNMm_uFQlrJq-SxOceAihtwawkmcexv_Brac3eA</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Wang, J-M</creator><creator>Su, C</creator><creator>Wang, Y</creator><creator>Huang, Y-J</creator><creator>Yang, Z</creator><creator>Chen, L</creator><creator>Wu, F</creator><creator>Xu, S-Y</creator><creator>Tao, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients</title><author>Wang, J-M ; Su, C ; Wang, Y ; Huang, Y-J ; Yang, Z ; Chen, L ; Wu, F ; Xu, S-Y ; Tao, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-b340bf3925ca7005cdef9aec9c61ecde395b9c939de879da47adff0d61fc79e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Ankle</topic><topic>Ankle Brachial Index - methods</topic><topic>Antihypertensive agents</topic><topic>Antihypertensive drugs</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Blood pressure</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular system</topic><topic>Case-Control Studies</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Diagnosis</topic><topic>Drug therapy</topic><topic>Elasticity</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Health Administration</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microparticles</topic><topic>Middle Aged</topic><topic>original-article</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - blood</topic><topic>Platelet Glycoprotein GPIb-IX Complex - metabolism</topic><topic>Plethysmography - methods</topic><topic>Public Health</topic><topic>Risk factors</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, J-M</creatorcontrib><creatorcontrib>Su, C</creatorcontrib><creatorcontrib>Wang, Y</creatorcontrib><creatorcontrib>Huang, Y-J</creatorcontrib><creatorcontrib>Yang, Z</creatorcontrib><creatorcontrib>Chen, L</creatorcontrib><creatorcontrib>Wu, F</creatorcontrib><creatorcontrib>Xu, S-Y</creatorcontrib><creatorcontrib>Tao, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, J-M</au><au>Su, C</au><au>Wang, Y</au><au>Huang, Y-J</au><au>Yang, Z</au><au>Chen, L</au><au>Wu, F</au><au>Xu, S-Y</au><au>Tao, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>23</volume><issue>5</issue><spage>307</spage><epage>315</epage><pages>307-315</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Vascular dysfunction in hypertensive condition is characterized by impaired endothelial function and reduced artery elasticity. Circulating endothelial microparticles (EMPs) and brachial–ankle pulse wave velocity (baPWV) are novel evaluation parameters for vascular function. However, their changes in patients with well-controlled blood pressure (BP) have not been fully acquired. To address this issue, circulating EMPs, defined as CD31+/CD42− MPs and baPWV were detected in 30 healthy subjects, 30 uncontrolled hypertensive (UCHT) patients and 23 well-controlled hypertensive (WCHT) patients. UCHT patients displayed elevated baPWV (
P
<0.01) and circulating EMPs (
P
<0.01) compared with healthy subjects. In WCHT patients, vascular damage represented by these two parameters constantly existed (
P
<0.01). Values of circulating EMPs were positively related to baPWV (
P
<0.01). Multivariate regression defined circulating EMPs as an independent contributor to the increase of baPWV value (
P
<0.05). Our study indicated that though BP was controlled, impaired endothelial function and arterial elasticity continued. The optimal therapy for patients with hypertension should include not only lowering BP but also improvement of vascular injury in parallel.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19037229</pmid><doi>10.1038/jhh.2008.137</doi><tpages>9</tpages></addata></record> |
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| subjects | Ankle Ankle Brachial Index - methods Antihypertensive agents Antihypertensive drugs Arterial hypertension. Arterial hypotension Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Blood pressure Cardiology. Vascular system Cardiovascular diseases Cardiovascular system Case-Control Studies Cell-Derived Microparticles - metabolism Cross-Sectional Studies Diagnosis Drug therapy Elasticity Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Epidemiology Female Flow Cytometry Health Administration Health aspects Humans Hypertension Hypertension - diagnosis Hypertension - physiopathology Male Medical sciences Medicine Medicine & Public Health Microparticles Middle Aged original-article Pharmacology. Drug treatments Platelet Endothelial Cell Adhesion Molecule-1 - blood Platelet Glycoprotein GPIb-IX Complex - metabolism Plethysmography - methods Public Health Risk factors Velocity |
| title | Elevated circulating endothelial microparticles and brachial–ankle pulse wave velocity in well-controlled hypertensive patients |
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