Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men
Few cohort studies have examined the association of carotid intima-media thickness (IMT) and plaque characteristics with the risk of stroke in apparently healthy persons. We examined the relationship of carotid IMT and the surface, morphology, and calcification of carotid plaques with the incidence...
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| Veröffentlicht in: | Stroke (1970) 2004-12, Vol.35 (12), p.2788-2794 |
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| container_title | Stroke (1970) |
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| creator | KITAMURA, Akihiko ISO, Hiroyasu IMANO, Hironori OHIRA, Tetsuya OKADA, Takeo SATO, Shinichi KIYAMA, Masahiko TANIGAWA, Takeshi YAMAGISHI, Kazumasa SHIMAMOTO, Takashi |
| description | Few cohort studies have examined the association of carotid intima-media thickness (IMT) and plaque characteristics with the risk of stroke in apparently healthy persons. We examined the relationship of carotid IMT and the surface, morphology, and calcification of carotid plaques with the incidence of stroke among Japanese men.
Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 1289 men aged 60 to 74 years without a previous stroke or coronary heart disease. In this cohort, the subsequent incidence of stroke was investigated.
During the 4.5-year follow-up, 34 strokes occurred. The multivariate-adjusted relative risk (95% CI) for the highest versus lowest quartiles of maximum IMT of the common carotid artery (CCA; > or =1.07 versus < or =0.77 mm) was 3.0 (1.1 to 8.3) for stroke. The combination of CCA and internal carotid artery (ICA) wall thickness was a better predictor of the risk of stroke than was CCA wall thickness alone. Men with a plaque, defined as a focal wall thickness of > or =1.5 mm, in the ICA had a 3-fold higher risk of stroke than those without a plaque, and the plaque surface irregularity further increased the stroke risk. A significant excess risk of stroke was confined to men with an uncalcified plaque.
Increased IMT of the CCA and an uncalcified plaque in the ICA, as assessed by ultrasonography, are risk factors for stroke in elderly Japanese men. |
| doi_str_mv | 10.1161/01.STR.0000147723.52033.9e |
| format | Article |
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Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 1289 men aged 60 to 74 years without a previous stroke or coronary heart disease. In this cohort, the subsequent incidence of stroke was investigated.
During the 4.5-year follow-up, 34 strokes occurred. The multivariate-adjusted relative risk (95% CI) for the highest versus lowest quartiles of maximum IMT of the common carotid artery (CCA; > or =1.07 versus < or =0.77 mm) was 3.0 (1.1 to 8.3) for stroke. The combination of CCA and internal carotid artery (ICA) wall thickness was a better predictor of the risk of stroke than was CCA wall thickness alone. Men with a plaque, defined as a focal wall thickness of > or =1.5 mm, in the ICA had a 3-fold higher risk of stroke than those without a plaque, and the plaque surface irregularity further increased the stroke risk. A significant excess risk of stroke was confined to men with an uncalcified plaque.
Increased IMT of the CCA and an uncalcified plaque in the ICA, as assessed by ultrasonography, are risk factors for stroke in elderly Japanese men.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000147723.52033.9e</identifier><identifier>PMID: 15528460</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Carotid Arteries - diagnostic imaging ; Carotid Stenosis - diagnostic imaging ; Carotid Stenosis - epidemiology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Japan - epidemiology ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Risk Factors ; Stroke - epidemiology ; Tunica Intima - diagnostic imaging ; Ultrasonography ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2004-12, Vol.35 (12), p.2788-2794</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-a97271dd970d7a992fe7b006824a3a58c46ae741482d3aaa352333e479e8984b3</citedby><cites>FETCH-LOGICAL-c502t-a97271dd970d7a992fe7b006824a3a58c46ae741482d3aaa352333e479e8984b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16318142$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15528460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KITAMURA, Akihiko</creatorcontrib><creatorcontrib>ISO, Hiroyasu</creatorcontrib><creatorcontrib>IMANO, Hironori</creatorcontrib><creatorcontrib>OHIRA, Tetsuya</creatorcontrib><creatorcontrib>OKADA, Takeo</creatorcontrib><creatorcontrib>SATO, Shinichi</creatorcontrib><creatorcontrib>KIYAMA, Masahiko</creatorcontrib><creatorcontrib>TANIGAWA, Takeshi</creatorcontrib><creatorcontrib>YAMAGISHI, Kazumasa</creatorcontrib><creatorcontrib>SHIMAMOTO, Takashi</creatorcontrib><title>Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Few cohort studies have examined the association of carotid intima-media thickness (IMT) and plaque characteristics with the risk of stroke in apparently healthy persons. We examined the relationship of carotid IMT and the surface, morphology, and calcification of carotid plaques with the incidence of stroke among Japanese men.
Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 1289 men aged 60 to 74 years without a previous stroke or coronary heart disease. In this cohort, the subsequent incidence of stroke was investigated.
During the 4.5-year follow-up, 34 strokes occurred. The multivariate-adjusted relative risk (95% CI) for the highest versus lowest quartiles of maximum IMT of the common carotid artery (CCA; > or =1.07 versus < or =0.77 mm) was 3.0 (1.1 to 8.3) for stroke. The combination of CCA and internal carotid artery (ICA) wall thickness was a better predictor of the risk of stroke than was CCA wall thickness alone. Men with a plaque, defined as a focal wall thickness of > or =1.5 mm, in the ICA had a 3-fold higher risk of stroke than those without a plaque, and the plaque surface irregularity further increased the stroke risk. A significant excess risk of stroke was confined to men with an uncalcified plaque.
Increased IMT of the CCA and an uncalcified plaque in the ICA, as assessed by ultrasonography, are risk factors for stroke in elderly Japanese men.</description><subject>Aged</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Stenosis - diagnostic imaging</subject><subject>Carotid Stenosis - epidemiology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Risk Factors</subject><subject>Stroke - epidemiology</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Ultrasonography</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LHDEUhoNUdGv9CxKEejdjvmaS9K4s2g-EQmuvw9nMGYw7H2sye-G_77EubEgISZ7z5vAwdi1FLWUrb4Ws_zz-rgUNaaxVum6U0Lr2eMJWslGmMq1yH9hKCO0rZbw_Zx9LeSZeadecsXPZNMqZVqzYuIY8L6njaVrSCNWIXQK-PKW4nbAUDlPHdwO87JHHJ8gQF8ypLCnSE01Ohy3v6XrOvKdVljxvkdL4T9gBRSDHocM8vPIRp0_stIeh4OVhv2B_7-8e19-rh1_ffqy_PlSxEWqpwFtlZdd5KzoL3qse7UaI1ikDGhoXTQtojTROdRoAdKO01misR-ed2egLdvOeu8sztV6WMKYScRioo3lfQmul1tIIAr-8gzHPpWTswy6ThvwapAhvsoOQgWSHo-zwX3bwSMVXh1_2G_J2LD3YJeDzAYASYegzTDGVI9dq6aRR-h9QzojN</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>KITAMURA, Akihiko</creator><creator>ISO, Hiroyasu</creator><creator>IMANO, Hironori</creator><creator>OHIRA, Tetsuya</creator><creator>OKADA, Takeo</creator><creator>SATO, Shinichi</creator><creator>KIYAMA, Masahiko</creator><creator>TANIGAWA, Takeshi</creator><creator>YAMAGISHI, Kazumasa</creator><creator>SHIMAMOTO, Takashi</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men</title><author>KITAMURA, Akihiko ; ISO, Hiroyasu ; IMANO, Hironori ; OHIRA, Tetsuya ; OKADA, Takeo ; SATO, Shinichi ; KIYAMA, Masahiko ; TANIGAWA, Takeshi ; YAMAGISHI, Kazumasa ; SHIMAMOTO, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-a97271dd970d7a992fe7b006824a3a58c46ae741482d3aaa352333e479e8984b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Stenosis - diagnostic imaging</topic><topic>Carotid Stenosis - epidemiology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Risk Factors</topic><topic>Stroke - epidemiology</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Ultrasonography</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KITAMURA, Akihiko</creatorcontrib><creatorcontrib>ISO, Hiroyasu</creatorcontrib><creatorcontrib>IMANO, Hironori</creatorcontrib><creatorcontrib>OHIRA, Tetsuya</creatorcontrib><creatorcontrib>OKADA, Takeo</creatorcontrib><creatorcontrib>SATO, Shinichi</creatorcontrib><creatorcontrib>KIYAMA, Masahiko</creatorcontrib><creatorcontrib>TANIGAWA, Takeshi</creatorcontrib><creatorcontrib>YAMAGISHI, Kazumasa</creatorcontrib><creatorcontrib>SHIMAMOTO, Takashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KITAMURA, Akihiko</au><au>ISO, Hiroyasu</au><au>IMANO, Hironori</au><au>OHIRA, Tetsuya</au><au>OKADA, Takeo</au><au>SATO, Shinichi</au><au>KIYAMA, Masahiko</au><au>TANIGAWA, Takeshi</au><au>YAMAGISHI, Kazumasa</au><au>SHIMAMOTO, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>35</volume><issue>12</issue><spage>2788</spage><epage>2794</epage><pages>2788-2794</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Few cohort studies have examined the association of carotid intima-media thickness (IMT) and plaque characteristics with the risk of stroke in apparently healthy persons. We examined the relationship of carotid IMT and the surface, morphology, and calcification of carotid plaques with the incidence of stroke among Japanese men.
Carotid IMT and plaque were evaluated bilaterally with ultrasonography in 1289 men aged 60 to 74 years without a previous stroke or coronary heart disease. In this cohort, the subsequent incidence of stroke was investigated.
During the 4.5-year follow-up, 34 strokes occurred. The multivariate-adjusted relative risk (95% CI) for the highest versus lowest quartiles of maximum IMT of the common carotid artery (CCA; > or =1.07 versus < or =0.77 mm) was 3.0 (1.1 to 8.3) for stroke. The combination of CCA and internal carotid artery (ICA) wall thickness was a better predictor of the risk of stroke than was CCA wall thickness alone. Men with a plaque, defined as a focal wall thickness of > or =1.5 mm, in the ICA had a 3-fold higher risk of stroke than those without a plaque, and the plaque surface irregularity further increased the stroke risk. A significant excess risk of stroke was confined to men with an uncalcified plaque.
Increased IMT of the CCA and an uncalcified plaque in the ICA, as assessed by ultrasonography, are risk factors for stroke in elderly Japanese men.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15528460</pmid><doi>10.1161/01.STR.0000147723.52033.9e</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection; American Heart Association; Journals@Ovid Complete |
| subjects | Aged Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Arteries - diagnostic imaging Carotid Stenosis - diagnostic imaging Carotid Stenosis - epidemiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Japan - epidemiology Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Risk Factors Stroke - epidemiology Tunica Intima - diagnostic imaging Ultrasonography Vascular diseases and vascular malformations of the nervous system |
| title | Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men |
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