INCENP (Inner Centromere Protein) is Overexpressed in High Grade Non-Hodgkin B-cell Lymphomas
Inner centromere protein (INCENP) is a member of the Chromosomal Passenger Complex (CPC), which is a four member protein complex essential for proper completion of mitosis and cell division (cytokinesis). Inappropriate chromosomal segregation and cytokinesis due to deregulated expression of chromoso...
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| Veröffentlicht in: | Pathology oncology research 2009-03, Vol.15 (1), p.11-17 |
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| creator | Barbanis, Sotirios Ioannou, Maria Kouvaras, Evangelos Karasavvidou, Foteini Nakou, Marianna Papamichali, Roidoula Koukoulis, George |
| description | Inner centromere protein (INCENP) is a member of the Chromosomal Passenger Complex (CPC), which is a four member protein complex essential for proper completion of mitosis and cell division (cytokinesis). Inappropriate chromosomal segregation and cytokinesis due to deregulated expression of chromosome passenger proteins may lead to aneuploidy and cancer including lymphomas. According to our knowledge this is the first study investigating immunohistochemical expression of INCENP in lymphoma cases and cancer tissues in general. Our purpose was to characterize the expression of INCENP in cases of non-Hodgkin B-cell lymphomas, to compare the immunoreactivity between low and high grades and to evaluate the correlation between INCENP and MIB-1 labeling indices. We examined INCENP and MIB-1 immunoreactivity in paraffin sections of 55 samples of non-Hodgkin B-cell lymphomas, obtained from 55 patients, 31 men and 24 women. Thirty were of high grade and 25 were of low grade. Our results showed significantly higher nuclear immunohistochemical expression of INCENP in high grade B-cell lymphomas versus low grade ones. Also INCENP expression was significantly correlated with MIB-1 labeling index. Taken together our results point to a possible association between increased INCENP immunostaining and B-cell lymphoma aggressiveness and also stress the need for further investigating the expression of INCENP and other mitotic regulatory proteins in lymphomas and other malignant neoplasms. |
| doi_str_mv | 10.1007/s12253-008-9094-0 |
| format | Article |
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Inappropriate chromosomal segregation and cytokinesis due to deregulated expression of chromosome passenger proteins may lead to aneuploidy and cancer including lymphomas. According to our knowledge this is the first study investigating immunohistochemical expression of INCENP in lymphoma cases and cancer tissues in general. Our purpose was to characterize the expression of INCENP in cases of non-Hodgkin B-cell lymphomas, to compare the immunoreactivity between low and high grades and to evaluate the correlation between INCENP and MIB-1 labeling indices. We examined INCENP and MIB-1 immunoreactivity in paraffin sections of 55 samples of non-Hodgkin B-cell lymphomas, obtained from 55 patients, 31 men and 24 women. Thirty were of high grade and 25 were of low grade. Our results showed significantly higher nuclear immunohistochemical expression of INCENP in high grade B-cell lymphomas versus low grade ones. Also INCENP expression was significantly correlated with MIB-1 labeling index. Taken together our results point to a possible association between increased INCENP immunostaining and B-cell lymphoma aggressiveness and also stress the need for further investigating the expression of INCENP and other mitotic regulatory proteins in lymphomas and other malignant neoplasms.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-008-9094-0</identifier><identifier>PMID: 18752045</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aged ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Burkitt Lymphoma - metabolism ; Burkitt Lymphoma - pathology ; Cancer Research ; Cell Differentiation ; Chromosomal Proteins, Non-Histone - metabolism ; Female ; Humans ; Immunoenzyme Techniques ; Immunology ; Lymphoma ; Lymphoma, B-Cell - metabolism ; Lymphoma, B-Cell - pathology ; Lymphoma, Follicular - metabolism ; Lymphoma, Follicular - pathology ; Lymphoma, Large B-Cell, Diffuse - metabolism ; Lymphoma, Large B-Cell, Diffuse - pathology ; Male ; Medical research ; Neoplasm Staging ; Oncology ; Original Paper ; Pathology ; Prognosis ; Proteins</subject><ispartof>Pathology oncology research, 2009-03, Vol.15 (1), p.11-17</ispartof><rights>Arányi Lajos Foundation 2008</rights><rights>Arányi Lajos Foundation 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-97c36e35bbf8b75956c41a5012a03f608fb18f0b004e190e1bb6b01e668c85ef3</citedby><cites>FETCH-LOGICAL-c370t-97c36e35bbf8b75956c41a5012a03f608fb18f0b004e190e1bb6b01e668c85ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-008-9094-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-008-9094-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18752045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbanis, Sotirios</creatorcontrib><creatorcontrib>Ioannou, Maria</creatorcontrib><creatorcontrib>Kouvaras, Evangelos</creatorcontrib><creatorcontrib>Karasavvidou, Foteini</creatorcontrib><creatorcontrib>Nakou, Marianna</creatorcontrib><creatorcontrib>Papamichali, Roidoula</creatorcontrib><creatorcontrib>Koukoulis, George</creatorcontrib><title>INCENP (Inner Centromere Protein) is Overexpressed in High Grade Non-Hodgkin B-cell Lymphomas</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description>Inner centromere protein (INCENP) is a member of the Chromosomal Passenger Complex (CPC), which is a four member protein complex essential for proper completion of mitosis and cell division (cytokinesis). Inappropriate chromosomal segregation and cytokinesis due to deregulated expression of chromosome passenger proteins may lead to aneuploidy and cancer including lymphomas. According to our knowledge this is the first study investigating immunohistochemical expression of INCENP in lymphoma cases and cancer tissues in general. Our purpose was to characterize the expression of INCENP in cases of non-Hodgkin B-cell lymphomas, to compare the immunoreactivity between low and high grades and to evaluate the correlation between INCENP and MIB-1 labeling indices. We examined INCENP and MIB-1 immunoreactivity in paraffin sections of 55 samples of non-Hodgkin B-cell lymphomas, obtained from 55 patients, 31 men and 24 women. Thirty were of high grade and 25 were of low grade. Our results showed significantly higher nuclear immunohistochemical expression of INCENP in high grade B-cell lymphomas versus low grade ones. Also INCENP expression was significantly correlated with MIB-1 labeling index. Taken together our results point to a possible association between increased INCENP immunostaining and B-cell lymphoma aggressiveness and also stress the need for further investigating the expression of INCENP and other mitotic regulatory proteins in lymphomas and other malignant neoplasms.</description><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Burkitt Lymphoma - metabolism</subject><subject>Burkitt Lymphoma - pathology</subject><subject>Cancer Research</subject><subject>Cell Differentiation</subject><subject>Chromosomal Proteins, Non-Histone - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunology</subject><subject>Lymphoma</subject><subject>Lymphoma, B-Cell - metabolism</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Lymphoma, Follicular - metabolism</subject><subject>Lymphoma, Follicular - pathology</subject><subject>Lymphoma, Large B-Cell, Diffuse - metabolism</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Proteins</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE9vEzEQxS0Eon_gA3BBlpBQObidsdde7xGi0kSK0h7giKz1ZjbdkrWDnSD67XGUSFSVOM1o_HvPT4-xdwiXCFBfZZRSKwFgRQNNJeAFO0WtpJAW6pdll9iIqtHmhJ3l_ABFYxrzmp2grbWESp-yH7PF5Hpxxy9mIVDiEwrbFEdKxO9S3NIQPvEh89vf5fJnkyhnWvIh8Omwuuc3qV0SX8QgpnG5-lnOX0RH6zWfP46b-zi2-Q171bfrTG-P85x9_3r9bTIV89ub2eTzXHSqhq1o6k4ZUtr73vpal8Bdha0GlC2o3oDtPdoePEBF2ACh98YDkjG2s5p6dc4-Hnw3Kf7aUd66ccj7KG2guMvO1KjQyKaAH56BD3GXQsnmEFFZaVVVFQoPVJdizol6t0nD2KZHh-D2zbtD86407_bNOyia90fnnR9p-U9xrLoA8gDk8hRWlJ58_V_Xv-Fki8U</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Barbanis, Sotirios</creator><creator>Ioannou, Maria</creator><creator>Kouvaras, Evangelos</creator><creator>Karasavvidou, Foteini</creator><creator>Nakou, Marianna</creator><creator>Papamichali, Roidoula</creator><creator>Koukoulis, George</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>INCENP (Inner Centromere Protein) is Overexpressed in High Grade Non-Hodgkin B-cell Lymphomas</title><author>Barbanis, Sotirios ; 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Oncol. Res</stitle><addtitle>Pathol Oncol Res</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>15</volume><issue>1</issue><spage>11</spage><epage>17</epage><pages>11-17</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract>Inner centromere protein (INCENP) is a member of the Chromosomal Passenger Complex (CPC), which is a four member protein complex essential for proper completion of mitosis and cell division (cytokinesis). Inappropriate chromosomal segregation and cytokinesis due to deregulated expression of chromosome passenger proteins may lead to aneuploidy and cancer including lymphomas. According to our knowledge this is the first study investigating immunohistochemical expression of INCENP in lymphoma cases and cancer tissues in general. Our purpose was to characterize the expression of INCENP in cases of non-Hodgkin B-cell lymphomas, to compare the immunoreactivity between low and high grades and to evaluate the correlation between INCENP and MIB-1 labeling indices. We examined INCENP and MIB-1 immunoreactivity in paraffin sections of 55 samples of non-Hodgkin B-cell lymphomas, obtained from 55 patients, 31 men and 24 women. Thirty were of high grade and 25 were of low grade. Our results showed significantly higher nuclear immunohistochemical expression of INCENP in high grade B-cell lymphomas versus low grade ones. Also INCENP expression was significantly correlated with MIB-1 labeling index. Taken together our results point to a possible association between increased INCENP immunostaining and B-cell lymphoma aggressiveness and also stress the need for further investigating the expression of INCENP and other mitotic regulatory proteins in lymphomas and other malignant neoplasms.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>18752045</pmid><doi>10.1007/s12253-008-9094-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Burkitt Lymphoma - metabolism Burkitt Lymphoma - pathology Cancer Research Cell Differentiation Chromosomal Proteins, Non-Histone - metabolism Female Humans Immunoenzyme Techniques Immunology Lymphoma Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - pathology Lymphoma, Follicular - metabolism Lymphoma, Follicular - pathology Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Male Medical research Neoplasm Staging Oncology Original Paper Pathology Prognosis Proteins |
| title | INCENP (Inner Centromere Protein) is Overexpressed in High Grade Non-Hodgkin B-cell Lymphomas |
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