Resting cerebral blood flow, attention, and aging
Abstract Aging is accompanied by a decline of fluid cognitive functions, e.g., a slowing of information processing, working memory, and division of attention. This is at least partly due to structural and functional changes in the aging brain. Although a decrement of resting cerebral blood flow (CBF...
Gespeichert in:
| Veröffentlicht in: | Brain research 2009-04, Vol.1267, p.77-88 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 88 |
|---|---|
| container_issue | |
| container_start_page | 77 |
| container_title | Brain research |
| container_volume | 1267 |
| creator | Bertsch, Katja Hagemann, Dirk Hermes, Michael Walter, Christof Khan, Robina Naumann, Ewald |
| description | Abstract Aging is accompanied by a decline of fluid cognitive functions, e.g., a slowing of information processing, working memory, and division of attention. This is at least partly due to structural and functional changes in the aging brain. Although a decrement of resting cerebral blood flow (CBF) has been positively associated with cognitive functions in patients with brain diseases, studies with healthy participants have revealed inconsistent results. Therefore, we investigated the relation between resting cerebral blood flow and cognitive functions (tonic and phasic alertness, selective and divided attention) in two samples of healthy young and older participants. We found higher resting CBF and better cognitive performances in the young than in the older sample. In addition, resting CBF was inversely correlated with selective attention in the young and with tonic alertness in the elderly participants. This finding is discussed with regard to the neural efficiency hypothesis of human intelligence. |
| doi_str_mv | 10.1016/j.brainres.2009.02.053 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67131346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0006899309004636</els_id><sourcerecordid>67131346</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-3d24b9280882b17a713944b3ca0ce7098ab531f9a93780b22a8bd7a20f1b85a73</originalsourceid><addsrcrecordid>eNqFkk2LFDEQhoMo7rj6F5a-6Mluq5LuTnIRl8UvWBD8OIckXb1k7EnWpEfZf2-GGRW87CkJPPVW8aQYu0DoEHB8te1ctiFmKh0H0B3wDgbxgG1QSd6OvIeHbAMAY6u0FmfsSSnb-hRCw2N2hppLLkbcMPxMZQ3xpvGUqUYujVtSmpp5Sb9eNnZdKa4hxXqNU2NvKvmUPZrtUujZ6Txn3969_Xr1ob3-9P7j1eV163vF11ZMvHeaK1CKO5RWotB974S34EmCVtYNAmdttZAKHOdWuUlaDjM6NVgpztmLY-5tTj_2dUqzC8XTsthIaV_MWBNR9OO9IIcBpe5FBccj6HMqJdNsbnPY2XxnEMzBqtmaP1bNwaoBbqrVWnhx6rB3O5r-lZ00VuD5CbDF22XONvpQ_nIcheolDpV7c-SoivsZKJviA0VPU8jkVzOlcP8sr_-L8EuIoXb9TndUtmmfY_0Wg6bUAvPlsAOHFQANUGWN4jcCHKtb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20517943</pqid></control><display><type>article</type><title>Resting cerebral blood flow, attention, and aging</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Bertsch, Katja ; Hagemann, Dirk ; Hermes, Michael ; Walter, Christof ; Khan, Robina ; Naumann, Ewald</creator><creatorcontrib>Bertsch, Katja ; Hagemann, Dirk ; Hermes, Michael ; Walter, Christof ; Khan, Robina ; Naumann, Ewald</creatorcontrib><description>Abstract Aging is accompanied by a decline of fluid cognitive functions, e.g., a slowing of information processing, working memory, and division of attention. This is at least partly due to structural and functional changes in the aging brain. Although a decrement of resting cerebral blood flow (CBF) has been positively associated with cognitive functions in patients with brain diseases, studies with healthy participants have revealed inconsistent results. Therefore, we investigated the relation between resting cerebral blood flow and cognitive functions (tonic and phasic alertness, selective and divided attention) in two samples of healthy young and older participants. We found higher resting CBF and better cognitive performances in the young than in the older sample. In addition, resting CBF was inversely correlated with selective attention in the young and with tonic alertness in the elderly participants. This finding is discussed with regard to the neural efficiency hypothesis of human intelligence.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2009.02.053</identifier><identifier>PMID: 19272361</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Aged ; Aging - physiology ; Analysis of Variance ; Attention ; Attention - physiology ; Biological and medical sciences ; Brain - blood supply ; Brain - physiology ; Brain perfusion ; Cerebrovascular Circulation ; Cognition - physiology ; Cognitive performance ; Continuous arterial spin labeling ; Development. Senescence. Regeneration. Transplantation ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural efficiency ; Neurology ; Neuropsychological Tests ; Reaction Time ; Regional Blood Flow ; Sex Characteristics ; Vertebrates: nervous system and sense organs ; Young Adult</subject><ispartof>Brain research, 2009-04, Vol.1267, p.77-88</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-3d24b9280882b17a713944b3ca0ce7098ab531f9a93780b22a8bd7a20f1b85a73</citedby><cites>FETCH-LOGICAL-c482t-3d24b9280882b17a713944b3ca0ce7098ab531f9a93780b22a8bd7a20f1b85a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2009.02.053$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21384715$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19272361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bertsch, Katja</creatorcontrib><creatorcontrib>Hagemann, Dirk</creatorcontrib><creatorcontrib>Hermes, Michael</creatorcontrib><creatorcontrib>Walter, Christof</creatorcontrib><creatorcontrib>Khan, Robina</creatorcontrib><creatorcontrib>Naumann, Ewald</creatorcontrib><title>Resting cerebral blood flow, attention, and aging</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract Aging is accompanied by a decline of fluid cognitive functions, e.g., a slowing of information processing, working memory, and division of attention. This is at least partly due to structural and functional changes in the aging brain. Although a decrement of resting cerebral blood flow (CBF) has been positively associated with cognitive functions in patients with brain diseases, studies with healthy participants have revealed inconsistent results. Therefore, we investigated the relation between resting cerebral blood flow and cognitive functions (tonic and phasic alertness, selective and divided attention) in two samples of healthy young and older participants. We found higher resting CBF and better cognitive performances in the young than in the older sample. In addition, resting CBF was inversely correlated with selective attention in the young and with tonic alertness in the elderly participants. This finding is discussed with regard to the neural efficiency hypothesis of human intelligence.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Analysis of Variance</subject><subject>Attention</subject><subject>Attention - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain - physiology</subject><subject>Brain perfusion</subject><subject>Cerebrovascular Circulation</subject><subject>Cognition - physiology</subject><subject>Cognitive performance</subject><subject>Continuous arterial spin labeling</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neural efficiency</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Reaction Time</subject><subject>Regional Blood Flow</subject><subject>Sex Characteristics</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Young Adult</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LFDEQhoMo7rj6F5a-6Mluq5LuTnIRl8UvWBD8OIckXb1k7EnWpEfZf2-GGRW87CkJPPVW8aQYu0DoEHB8te1ctiFmKh0H0B3wDgbxgG1QSd6OvIeHbAMAY6u0FmfsSSnb-hRCw2N2hppLLkbcMPxMZQ3xpvGUqUYujVtSmpp5Sb9eNnZdKa4hxXqNU2NvKvmUPZrtUujZ6Txn3969_Xr1ob3-9P7j1eV163vF11ZMvHeaK1CKO5RWotB974S34EmCVtYNAmdttZAKHOdWuUlaDjM6NVgpztmLY-5tTj_2dUqzC8XTsthIaV_MWBNR9OO9IIcBpe5FBccj6HMqJdNsbnPY2XxnEMzBqtmaP1bNwaoBbqrVWnhx6rB3O5r-lZ00VuD5CbDF22XONvpQ_nIcheolDpV7c-SoivsZKJviA0VPU8jkVzOlcP8sr_-L8EuIoXb9TndUtmmfY_0Wg6bUAvPlsAOHFQANUGWN4jcCHKtb</recordid><startdate>20090424</startdate><enddate>20090424</enddate><creator>Bertsch, Katja</creator><creator>Hagemann, Dirk</creator><creator>Hermes, Michael</creator><creator>Walter, Christof</creator><creator>Khan, Robina</creator><creator>Naumann, Ewald</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090424</creationdate><title>Resting cerebral blood flow, attention, and aging</title><author>Bertsch, Katja ; Hagemann, Dirk ; Hermes, Michael ; Walter, Christof ; Khan, Robina ; Naumann, Ewald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-3d24b9280882b17a713944b3ca0ce7098ab531f9a93780b22a8bd7a20f1b85a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Analysis of Variance</topic><topic>Attention</topic><topic>Attention - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain - blood supply</topic><topic>Brain - physiology</topic><topic>Brain perfusion</topic><topic>Cerebrovascular Circulation</topic><topic>Cognition - physiology</topic><topic>Cognitive performance</topic><topic>Continuous arterial spin labeling</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neural efficiency</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Reaction Time</topic><topic>Regional Blood Flow</topic><topic>Sex Characteristics</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bertsch, Katja</creatorcontrib><creatorcontrib>Hagemann, Dirk</creatorcontrib><creatorcontrib>Hermes, Michael</creatorcontrib><creatorcontrib>Walter, Christof</creatorcontrib><creatorcontrib>Khan, Robina</creatorcontrib><creatorcontrib>Naumann, Ewald</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bertsch, Katja</au><au>Hagemann, Dirk</au><au>Hermes, Michael</au><au>Walter, Christof</au><au>Khan, Robina</au><au>Naumann, Ewald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resting cerebral blood flow, attention, and aging</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2009-04-24</date><risdate>2009</risdate><volume>1267</volume><spage>77</spage><epage>88</epage><pages>77-88</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Abstract Aging is accompanied by a decline of fluid cognitive functions, e.g., a slowing of information processing, working memory, and division of attention. This is at least partly due to structural and functional changes in the aging brain. Although a decrement of resting cerebral blood flow (CBF) has been positively associated with cognitive functions in patients with brain diseases, studies with healthy participants have revealed inconsistent results. Therefore, we investigated the relation between resting cerebral blood flow and cognitive functions (tonic and phasic alertness, selective and divided attention) in two samples of healthy young and older participants. We found higher resting CBF and better cognitive performances in the young than in the older sample. In addition, resting CBF was inversely correlated with selective attention in the young and with tonic alertness in the elderly participants. This finding is discussed with regard to the neural efficiency hypothesis of human intelligence.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19272361</pmid><doi>10.1016/j.brainres.2009.02.053</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2009-04, Vol.1267, p.77-88 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67131346 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Aging - physiology Analysis of Variance Attention Attention - physiology Biological and medical sciences Brain - blood supply Brain - physiology Brain perfusion Cerebrovascular Circulation Cognition - physiology Cognitive performance Continuous arterial spin labeling Development. Senescence. Regeneration. Transplantation Female Fundamental and applied biological sciences. Psychology Humans Magnetic Resonance Imaging Male Middle Aged Neural efficiency Neurology Neuropsychological Tests Reaction Time Regional Blood Flow Sex Characteristics Vertebrates: nervous system and sense organs Young Adult |
| title | Resting cerebral blood flow, attention, and aging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T18%3A01%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resting%20cerebral%20blood%20flow,%20attention,%20and%20aging&rft.jtitle=Brain%20research&rft.au=Bertsch,%20Katja&rft.date=2009-04-24&rft.volume=1267&rft.spage=77&rft.epage=88&rft.pages=77-88&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/j.brainres.2009.02.053&rft_dat=%3Cproquest_cross%3E67131346%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20517943&rft_id=info:pmid/19272361&rft_els_id=1_s2_0_S0006899309004636&rfr_iscdi=true |