The Small GTPase Rac2 Controls Phagosomal Alkalinization and Antigen Crosspresentation Selectively in CD8 + Dendritic Cells

A unique subpopulation of spleen dendritic cells (DCs) that express the CD8 surface marker efficiently present phagocytosed antigens to CD8 + T lymphocytes in a process called “crosspresentation,” which initiates cytotoxic immune responses. We now show that the small GTPase Rac2 plays a critical rol...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2009-04, Vol.30 (4), p.544-555
Hauptverfasser:	Savina, Ariel, Peres, Audrey, Cebrian, Ignacio, Carmo, Nuno, Moita, Catarina, Hacohen, Nir, Moita, Luis F., Amigorena, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Amino acids Animals Bone marrow Cancer CD8 Antigens CELLIMMUNO Cells, Cultured Cross-Priming Dendritic Cells - immunology Enzymes Fluorescent Antibody Technique Hydrogen-Ion Concentration Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic MOLIMMUNO NADPH Oxidase 2 NADPH Oxidases - metabolism Peptides Phagosomes - immunology Plasmids rac GTP-Binding Proteins - metabolism RAC2 GTP-Binding Protein Reactive Oxygen Species - metabolism Spleen
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