A Deoxyribozyme, Sero1C, Uses Light and Serotonin to Repair Diverse Pyrimidine Dimers in DNA

An in vitro selection search for DNAs capable of catalyzing photochemistry yielded two distinctive deoxyribozymes (DNAzymes) with photolyase activity: UV1C, which repaired thymine dimers within DNA using a UV light of > 300 nm wavelength and no extraneous cofactor, and Sero1C, which required the...

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Veröffentlicht in:	Journal of molecular biology 2009-04, Vol.388 (1), p.21-29
Hauptverfasser:	Thorne, Rebecca E., Chinnapen, Daniel J.-F., Sekhon, Gurpreet S., Sen, Dipankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence deoxyribozyme DNA - chemistry DNA Repair DNA, Catalytic - chemistry DNA, Catalytic - metabolism Kinetics Models, Biological Molecular Sequence Data Nucleic Acid Conformation Photochemistry photolyase pyrimidine dimers Pyrimidine Dimers - chemistry Pyrimidine Dimers - metabolism ribozyme serotonin Serotonin - chemistry Substrate Specificity
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