Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

Inhibitors of α v β 3 and α v β 5 integrins have previously been shown to inhibit tumor angiogenesis and growth and have entered human clinical trials. Andrew Reynolds and his coworkers now show that low (nanomolar) concentrations of these inhibitors can unexpectedly promote VEGF-dependent tumor ang...

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