Examination of the mechanisms of osteolysis in patients with metastatic breast cancer

The benefits of bisphosphonates (BPs) in reducing skeletal-related events (SREs) in patients with bone metastases has mainly been attributed to their potent osteoclast inhibiting effect. However, despite the use of modern systemic anticancer therapy including potent BPs, many patients with bone meta...

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Veröffentlicht in:	Oncology reports 2009-05, Vol.21 (5), p.1153-1159
Hauptverfasser:	TRINKAUS, Mateya, WEI SEONG OOI, AMIR, Ethan, POPOVIC, Snezana, KALINA, Marion, KAHN, Hariette, SINGH, Gurmit, GAINFORD, Mary Corona, CLEMONS, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Neoplasms - secondary Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Diseases of the osteoarticular system Female Humans Immunohistochemistry Medical sciences Middle Aged Neoplasm Staging Osteoblasts - pathology Osteoclasts - pathology Osteolysis - genetics Osteolysis - metabolism Osteolysis - pathology RANK Ligand - biosynthesis RANK Ligand - genetics Receptor Activator of Nuclear Factor-kappa B - biosynthesis Receptor Activator of Nuclear Factor-kappa B - genetics Retrospective Studies Tumors Tumors of striated muscle and skeleton Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics
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