Inhibition of Ataxia Telangiectasia Mutated Kinase Activity Enhances TRAIL-Mediated Apoptosis in Human Melanoma Cells

The aim of the present study was to elucidate the effects of ataxia telangiectasia mutated (ATM) kinase on the regulation of the extrinsic tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 2/DR5-mediated death pathway in human melanoma cells. We revealed that total ATM protein...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-04, Vol.69 (8), p.3510-3519
Hauptverfasser:	IVANOV, Vladimir N, HONGNING ZHOU, PARTRIDGE, Michael A, HEI, Tom K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Apoptosis - drug effects Ataxia Telangiectasia Mutated Proteins Biological and medical sciences CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - genetics Cell Line, Tumor Dermatology DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics Humans Medical sciences Melanoma - drug therapy Melanoma - enzymology Melanoma - metabolism Melanoma - pathology Mice Mice, Inbred BALB C Mice, Nude Morpholines - pharmacology NF-kappa B - metabolism Pharmacology. Drug treatments Phosphorylation Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Pyrones - pharmacology Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism RNA, Small Interfering - genetics STAT3 Transcription Factor - metabolism TNF-Related Apoptosis-Inducing Ligand - pharmacology Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics Tumors Tumors of the skin and soft tissue. Premalignant lesions Xenograft Model Antitumor Assays
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