An investigation of temperament endophenotype candidates for early emergence of the core cognitive component of eating disorders
This study was designed to investigate potential temperament endophenotypes for clinically significant importance of shape and weight. Seven temperament risk factors for eating disorders and the Eating Disorder Examination were assessed in 699 female twins aged 12-15 years. Each variable was evaluat...
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| Veröffentlicht in: | Psychological medicine 2009-05, Vol.39 (5), p.811-821 |
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| creator | Wilksch, S. M. Wade, T. D. |
| description | This study was designed to investigate potential temperament endophenotypes for clinically significant importance of shape and weight.
Seven temperament risk factors for eating disorders and the Eating Disorder Examination were assessed in 699 female twins aged 12-15 years. Each variable was evaluated against the following endophenotype criteria: associated with illness in the general population; found in non-affected family members at a higher rate than in the general population; and, heritable.
All seven variables were significantly associated with clinically significant importance of shape and weight, while thin-ideal internalization, ineffectiveness, body dissatisfaction and sensitivity to punishment were found at significantly elevated levels in non-affected twins, when controlling for sister's temperament score. These four variables had genetic correlations with importance of shape and weight, ranging from 0.48 to 0.95.
Future research should evaluate the stability of the identified endophenotypes and their utility for predicting significant growth in importance of shape and weight, and also whether different endophenotypes emerge when the importance of weight and shape reaches its peak in adolescents, around 15 to 16 years of age. |
| doi_str_mv | 10.1017/S0033291708004261 |
| format | Article |
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Seven temperament risk factors for eating disorders and the Eating Disorder Examination were assessed in 699 female twins aged 12-15 years. Each variable was evaluated against the following endophenotype criteria: associated with illness in the general population; found in non-affected family members at a higher rate than in the general population; and, heritable.
All seven variables were significantly associated with clinically significant importance of shape and weight, while thin-ideal internalization, ineffectiveness, body dissatisfaction and sensitivity to punishment were found at significantly elevated levels in non-affected twins, when controlling for sister's temperament score. These four variables had genetic correlations with importance of shape and weight, ranging from 0.48 to 0.95.
Future research should evaluate the stability of the identified endophenotypes and their utility for predicting significant growth in importance of shape and weight, and also whether different endophenotypes emerge when the importance of weight and shape reaches its peak in adolescents, around 15 to 16 years of age.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291708004261</identifier><identifier>PMID: 18752731</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult and adolescent clinical studies ; Anorexia Nervosa - epidemiology ; Anorexia Nervosa - genetics ; Anorexia Nervosa - psychology ; Biological and medical sciences ; Body Image ; Bulimia Nervosa - epidemiology ; Bulimia Nervosa - genetics ; Bulimia Nervosa - psychology ; Child ; Cognition & reasoning ; Cross-Sectional Studies ; Diseases in Twins - epidemiology ; Diseases in Twins - genetics ; Diseases in Twins - psychology ; Eating behavior disorders ; Eating disorders ; Female ; Genotype & phenotype ; Humans ; importance of shape and weight ; Internalization ; Medical sciences ; Miscellaneous ; Personality Assessment - statistics & numerical data ; Phenotype ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychometrics ; Psychopathology. Psychiatry ; Punishment ; Reference Values ; Risk Factors ; Self Concept ; Temperament ; twin studies ; Twins</subject><ispartof>Psychological medicine, 2009-05, Vol.39 (5), p.811-821</ispartof><rights>Copyright © Cambridge University Press 2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-62be7a25335b3bde5e165a9389b99e7b5e832ef09419bef2572e9b5ccac08a713</citedby><cites>FETCH-LOGICAL-c500t-62be7a25335b3bde5e165a9389b99e7b5e832ef09419bef2572e9b5ccac08a713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291708004261/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,12837,27915,27916,30990,30991,55619</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21331456$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18752731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilksch, S. M.</creatorcontrib><creatorcontrib>Wade, T. D.</creatorcontrib><title>An investigation of temperament endophenotype candidates for early emergence of the core cognitive component of eating disorders</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>This study was designed to investigate potential temperament endophenotypes for clinically significant importance of shape and weight.
Seven temperament risk factors for eating disorders and the Eating Disorder Examination were assessed in 699 female twins aged 12-15 years. Each variable was evaluated against the following endophenotype criteria: associated with illness in the general population; found in non-affected family members at a higher rate than in the general population; and, heritable.
All seven variables were significantly associated with clinically significant importance of shape and weight, while thin-ideal internalization, ineffectiveness, body dissatisfaction and sensitivity to punishment were found at significantly elevated levels in non-affected twins, when controlling for sister's temperament score. These four variables had genetic correlations with importance of shape and weight, ranging from 0.48 to 0.95.
Future research should evaluate the stability of the identified endophenotypes and their utility for predicting significant growth in importance of shape and weight, and also whether different endophenotypes emerge when the importance of weight and shape reaches its peak in adolescents, around 15 to 16 years of age.</description><subject>Adolescent</subject><subject>Adult and adolescent clinical studies</subject><subject>Anorexia Nervosa - epidemiology</subject><subject>Anorexia Nervosa - genetics</subject><subject>Anorexia Nervosa - psychology</subject><subject>Biological and medical sciences</subject><subject>Body Image</subject><subject>Bulimia Nervosa - epidemiology</subject><subject>Bulimia Nervosa - genetics</subject><subject>Bulimia Nervosa - psychology</subject><subject>Child</subject><subject>Cognition & reasoning</subject><subject>Cross-Sectional Studies</subject><subject>Diseases in Twins - epidemiology</subject><subject>Diseases in Twins - genetics</subject><subject>Diseases in Twins - psychology</subject><subject>Eating behavior disorders</subject><subject>Eating disorders</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>importance of shape and weight</subject><subject>Internalization</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Personality Assessment - statistics & numerical data</subject><subject>Phenotype</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychometrics</subject><subject>Psychopathology. Psychiatry</subject><subject>Punishment</subject><subject>Reference Values</subject><subject>Risk Factors</subject><subject>Self Concept</subject><subject>Temperament</subject><subject>twin studies</subject><subject>Twins</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks1u1TAQhS0EopfCA7BBFhLsAv6J43hZCi2ICoRa2EaOM0ldEjvYvhV3x6PjcKNWAqFubEvnm-MZHyP0lJJXlFD5-pwQzpmiktSElKyi99CGlpUqaiXr-2izyMWiH6BHMV4RQjkt2UN0QGspmOR0g34dOWzdNcRkB52sd9j3OME0Q9ATuITBdX6-BOfTbgZstOtspxNE3PuAQYdxh2GCMIAz8Kf2MlM-LMvgbLLXy2mavVvMsg75FjfgzkYfOgjxMXrQ6zHCk3U_RF9P3l0cvy_OPp9-OD46K4wgJBUVa0FqJjgXLW87EEAroRWvVasUyFZAzRn0RJVUtdAzIRmoVhijDam1pPwQvdz7zsH_2OZ5m8lGA-OoHfhtbCpJmVCK3wlmZ8nLsrwTZETUVQ4lg8__Aq_8Nrg8bWbKUknBFze6h0zwMQbomznYSYddQ0mzpN38k3auebYab9sJutuKNd4MvFgBHY0e-6CdsfGGY5TnDyGqzBV7zsYEP290Hb7nd-FSNNXpl4acfHxz_u3tp-Yi83xtVk9tsN0AtyP9v93fTvXRZw</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Wilksch, S. 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M. ; Wade, T. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-62be7a25335b3bde5e165a9389b99e7b5e832ef09419bef2572e9b5ccac08a713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult and adolescent clinical studies</topic><topic>Anorexia Nervosa - epidemiology</topic><topic>Anorexia Nervosa - genetics</topic><topic>Anorexia Nervosa - psychology</topic><topic>Biological and medical sciences</topic><topic>Body Image</topic><topic>Bulimia Nervosa - epidemiology</topic><topic>Bulimia Nervosa - genetics</topic><topic>Bulimia Nervosa - psychology</topic><topic>Child</topic><topic>Cognition & reasoning</topic><topic>Cross-Sectional Studies</topic><topic>Diseases in Twins - epidemiology</topic><topic>Diseases in Twins - genetics</topic><topic>Diseases in Twins - psychology</topic><topic>Eating behavior disorders</topic><topic>Eating disorders</topic><topic>Female</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>importance of shape and weight</topic><topic>Internalization</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Personality Assessment - statistics & numerical data</topic><topic>Phenotype</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychometrics</topic><topic>Psychopathology. Psychiatry</topic><topic>Punishment</topic><topic>Reference Values</topic><topic>Risk Factors</topic><topic>Self Concept</topic><topic>Temperament</topic><topic>twin studies</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilksch, S. M.</creatorcontrib><creatorcontrib>Wade, T. 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M.</au><au>Wade, T. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An investigation of temperament endophenotype candidates for early emergence of the core cognitive component of eating disorders</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>39</volume><issue>5</issue><spage>811</spage><epage>821</epage><pages>811-821</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>This study was designed to investigate potential temperament endophenotypes for clinically significant importance of shape and weight.
Seven temperament risk factors for eating disorders and the Eating Disorder Examination were assessed in 699 female twins aged 12-15 years. Each variable was evaluated against the following endophenotype criteria: associated with illness in the general population; found in non-affected family members at a higher rate than in the general population; and, heritable.
All seven variables were significantly associated with clinically significant importance of shape and weight, while thin-ideal internalization, ineffectiveness, body dissatisfaction and sensitivity to punishment were found at significantly elevated levels in non-affected twins, when controlling for sister's temperament score. These four variables had genetic correlations with importance of shape and weight, ranging from 0.48 to 0.95.
Future research should evaluate the stability of the identified endophenotypes and their utility for predicting significant growth in importance of shape and weight, and also whether different endophenotypes emerge when the importance of weight and shape reaches its peak in adolescents, around 15 to 16 years of age.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>18752731</pmid><doi>10.1017/S0033291708004261</doi><tpages>11</tpages></addata></record> |
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| ispartof | Psychological medicine, 2009-05, Vol.39 (5), p.811-821 |
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| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Cambridge University Press Journals Complete |
| subjects | Adolescent Adult and adolescent clinical studies Anorexia Nervosa - epidemiology Anorexia Nervosa - genetics Anorexia Nervosa - psychology Biological and medical sciences Body Image Bulimia Nervosa - epidemiology Bulimia Nervosa - genetics Bulimia Nervosa - psychology Child Cognition & reasoning Cross-Sectional Studies Diseases in Twins - epidemiology Diseases in Twins - genetics Diseases in Twins - psychology Eating behavior disorders Eating disorders Female Genotype & phenotype Humans importance of shape and weight Internalization Medical sciences Miscellaneous Personality Assessment - statistics & numerical data Phenotype Psychiatry Psychology. Psychoanalysis. Psychiatry Psychometrics Psychopathology. Psychiatry Punishment Reference Values Risk Factors Self Concept Temperament twin studies Twins |
| title | An investigation of temperament endophenotype candidates for early emergence of the core cognitive component of eating disorders |
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