Impact of anti- Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study
In order to test the impact of Giardia and geohelminthic infection on infant growth faltering in Bangladesh, a randomised double-blind placebo controlled intervention of 36 weeks’ duration was conducted in a rural community located 40 km northwest of Dhaka. Infants aged between 3 and 15 months were...
Gespeichert in:
| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 2009-05, Vol.103 (5), p.520-529 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 529 |
|---|---|
| container_issue | 5 |
| container_start_page | 520 |
| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| container_volume | 103 |
| creator | Goto, Rie Mascie-Taylor, C.G. Nicholas Lunn, Peter G. |
| description | In order to test the impact of
Giardia and geohelminthic infection on infant growth faltering in Bangladesh, a randomised double-blind placebo controlled intervention of 36 weeks’ duration was conducted in a rural community located 40
km northwest of Dhaka. Infants aged between 3 and 15 months were randomly assigned to either anti-
Giardia and anthelminthic treatment, anti-
Giardia treatment only, or a control. Weight and supine length were recorded every 4 weeks. Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and
Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and
G. intestinalis cysts were determined. Data on 222 fully compliant infants were analysed. No significant differences in intestinal permeability, biochemical or anthropometric variables were found between the intervention groups, although there were associations between improvement in small intestinal mucosal function and better weight-for-age and weight-for-height (length)
Z-scores. GSIgM titres indicated high endemicity with rapid re-infection of
Giardia among infants; over 95% of infants were positive throughout the study, whereas the stool examination showed very few infants with either geohelminth eggs or
Giardia cysts (ClinicalTrials.gov Identifier:
NCT00607074). |
| doi_str_mv | 10.1016/j.trstmh.2008.07.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67124955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1016/j.trstmh.2008.07.020</oup_id><els_id>S0035920308003349</els_id><sourcerecordid>20189210</sourcerecordid><originalsourceid>FETCH-LOGICAL-c524t-5c1c378a60c7d81a8c9020310a35a63e94f8acc7e2e9fc1b91a981aff0c8dc023</originalsourceid><addsrcrecordid>eNqNkctuEzEUhi0EoiHwBgh5A7tJfZmbWSC1FbQVFUgIEGJjOfaZxsEzDranJW_Do-JhorIDVkc-_v5z-xF6SsmKElofb1cpxNRvVoyQdkWaFWHkHlrQtmkLXhF-Hy0I4VUhGOFH6FGMW0JYRSvxEB1NkCjreoF-XvY7pRP2HVZDsgU-tyoYq_LLTJkNuN7mYDVOAVTqYcjwgO3Q5V98Hfxt2vyGMwUx2UE5vIPQg1pbZ9M-53EYQ86equHaKQNx8xIrHLLG9zaCwcaPawfF2tlcRvshBe9czsc0mv1j9KBTLsKTQ1yiT29efzy7KK7en1-enVwVumJlKipNNW9aVRPdmJaqVot8D06J4pWqOYiya5XWDTAQnaZrQZXIWNcR3RpNGF-iF3PdXfDfx7yJzMNpcE4N4Mco64ayUlTVP0FGaCsYJRksZ1AHH2OATu6C7VXYS0rkZKHcytlCOVkoSSOnkZfo2aH-uO7B_BEdPMvA8wOgolauy5fUNt5xjJZUiGYqdDxzftz9b-tiVtiY4MedRoVveX3eVPLiy1f5-bR-R97yD5Jm_tXMQzbmxkKQUVsYNBgbQCdpvP17w1-et94f</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20189210</pqid></control><display><type>article</type><title>Impact of anti- Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><creator>Goto, Rie ; Mascie-Taylor, C.G. Nicholas ; Lunn, Peter G.</creator><creatorcontrib>Goto, Rie ; Mascie-Taylor, C.G. Nicholas ; Lunn, Peter G.</creatorcontrib><description>In order to test the impact of
Giardia and geohelminthic infection on infant growth faltering in Bangladesh, a randomised double-blind placebo controlled intervention of 36 weeks’ duration was conducted in a rural community located 40
km northwest of Dhaka. Infants aged between 3 and 15 months were randomly assigned to either anti-
Giardia and anthelminthic treatment, anti-
Giardia treatment only, or a control. Weight and supine length were recorded every 4 weeks. Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and
Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and
G. intestinalis cysts were determined. Data on 222 fully compliant infants were analysed. No significant differences in intestinal permeability, biochemical or anthropometric variables were found between the intervention groups, although there were associations between improvement in small intestinal mucosal function and better weight-for-age and weight-for-height (length)
Z-scores. GSIgM titres indicated high endemicity with rapid re-infection of
Giardia among infants; over 95% of infants were positive throughout the study, whereas the stool examination showed very few infants with either geohelminth eggs or
Giardia cysts (ClinicalTrials.gov Identifier:
NCT00607074).</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1016/j.trstmh.2008.07.020</identifier><identifier>PMID: 18789466</identifier><identifier>CODEN: TRSTAZ</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Albendazole - therapeutic use ; Animals ; Anthelmintics - therapeutic use ; Anthropometry ; Antiprotozoal Agents - therapeutic use ; Bangladesh ; Biological and medical sciences ; Breast Feeding - statistics & numerical data ; Double-Blind Method ; Female ; General aspects ; Giardia intestinalis ; Giardiasis - complications ; Giardiasis - drug therapy ; Growth ; Growth Disorders - etiology ; Helminths ; Humans ; Infant ; Intestinal absorption ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - parasitology ; Longitudinal Studies ; Male ; Malnutrition ; Medical sciences ; Metabolic diseases ; Metronidazole - analogs & derivatives ; Metronidazole - therapeutic use ; Mothers - education ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 2009-05, Vol.103 (5), p.520-529</ispartof><rights>2008 Royal Society of Tropical Medicine and Hygiene</rights><rights>Royal Society of Tropical Medicine and Hygiene 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-5c1c378a60c7d81a8c9020310a35a63e94f8acc7e2e9fc1b91a981aff0c8dc023</citedby><cites>FETCH-LOGICAL-c524t-5c1c378a60c7d81a8c9020310a35a63e94f8acc7e2e9fc1b91a981aff0c8dc023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21419970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18789466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goto, Rie</creatorcontrib><creatorcontrib>Mascie-Taylor, C.G. Nicholas</creatorcontrib><creatorcontrib>Lunn, Peter G.</creatorcontrib><title>Impact of anti- Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>In order to test the impact of
Giardia and geohelminthic infection on infant growth faltering in Bangladesh, a randomised double-blind placebo controlled intervention of 36 weeks’ duration was conducted in a rural community located 40
km northwest of Dhaka. Infants aged between 3 and 15 months were randomly assigned to either anti-
Giardia and anthelminthic treatment, anti-
Giardia treatment only, or a control. Weight and supine length were recorded every 4 weeks. Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and
Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and
G. intestinalis cysts were determined. Data on 222 fully compliant infants were analysed. No significant differences in intestinal permeability, biochemical or anthropometric variables were found between the intervention groups, although there were associations between improvement in small intestinal mucosal function and better weight-for-age and weight-for-height (length)
Z-scores. GSIgM titres indicated high endemicity with rapid re-infection of
Giardia among infants; over 95% of infants were positive throughout the study, whereas the stool examination showed very few infants with either geohelminth eggs or
Giardia cysts (ClinicalTrials.gov Identifier:
NCT00607074).</description><subject>Albendazole - therapeutic use</subject><subject>Animals</subject><subject>Anthelmintics - therapeutic use</subject><subject>Anthropometry</subject><subject>Antiprotozoal Agents - therapeutic use</subject><subject>Bangladesh</subject><subject>Biological and medical sciences</subject><subject>Breast Feeding - statistics & numerical data</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>General aspects</subject><subject>Giardia intestinalis</subject><subject>Giardiasis - complications</subject><subject>Giardiasis - drug therapy</subject><subject>Growth</subject><subject>Growth Disorders - etiology</subject><subject>Helminths</subject><subject>Humans</subject><subject>Infant</subject><subject>Intestinal absorption</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - parasitology</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metronidazole - analogs & derivatives</subject><subject>Metronidazole - therapeutic use</subject><subject>Mothers - education</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctuEzEUhi0EoiHwBgh5A7tJfZmbWSC1FbQVFUgIEGJjOfaZxsEzDranJW_Do-JhorIDVkc-_v5z-xF6SsmKElofb1cpxNRvVoyQdkWaFWHkHlrQtmkLXhF-Hy0I4VUhGOFH6FGMW0JYRSvxEB1NkCjreoF-XvY7pRP2HVZDsgU-tyoYq_LLTJkNuN7mYDVOAVTqYcjwgO3Q5V98Hfxt2vyGMwUx2UE5vIPQg1pbZ9M-53EYQ86equHaKQNx8xIrHLLG9zaCwcaPawfF2tlcRvshBe9czsc0mv1j9KBTLsKTQ1yiT29efzy7KK7en1-enVwVumJlKipNNW9aVRPdmJaqVot8D06J4pWqOYiya5XWDTAQnaZrQZXIWNcR3RpNGF-iF3PdXfDfx7yJzMNpcE4N4Mco64ayUlTVP0FGaCsYJRksZ1AHH2OATu6C7VXYS0rkZKHcytlCOVkoSSOnkZfo2aH-uO7B_BEdPMvA8wOgolauy5fUNt5xjJZUiGYqdDxzftz9b-tiVtiY4MedRoVveX3eVPLiy1f5-bR-R97yD5Jm_tXMQzbmxkKQUVsYNBgbQCdpvP17w1-et94f</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Goto, Rie</creator><creator>Mascie-Taylor, C.G. Nicholas</creator><creator>Lunn, Peter G.</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Impact of anti- Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study</title><author>Goto, Rie ; Mascie-Taylor, C.G. Nicholas ; Lunn, Peter G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-5c1c378a60c7d81a8c9020310a35a63e94f8acc7e2e9fc1b91a981aff0c8dc023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Albendazole - therapeutic use</topic><topic>Animals</topic><topic>Anthelmintics - therapeutic use</topic><topic>Anthropometry</topic><topic>Antiprotozoal Agents - therapeutic use</topic><topic>Bangladesh</topic><topic>Biological and medical sciences</topic><topic>Breast Feeding - statistics & numerical data</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>General aspects</topic><topic>Giardia intestinalis</topic><topic>Giardiasis - complications</topic><topic>Giardiasis - drug therapy</topic><topic>Growth</topic><topic>Growth Disorders - etiology</topic><topic>Helminths</topic><topic>Humans</topic><topic>Infant</topic><topic>Intestinal absorption</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - parasitology</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metronidazole - analogs & derivatives</topic><topic>Metronidazole - therapeutic use</topic><topic>Mothers - education</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goto, Rie</creatorcontrib><creatorcontrib>Mascie-Taylor, C.G. Nicholas</creatorcontrib><creatorcontrib>Lunn, Peter G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goto, Rie</au><au>Mascie-Taylor, C.G. Nicholas</au><au>Lunn, Peter G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of anti- Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><stitle>Trans R Soc Trop Med Hyg</stitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>103</volume><issue>5</issue><spage>520</spage><epage>529</epage><pages>520-529</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>In order to test the impact of
Giardia and geohelminthic infection on infant growth faltering in Bangladesh, a randomised double-blind placebo controlled intervention of 36 weeks’ duration was conducted in a rural community located 40
km northwest of Dhaka. Infants aged between 3 and 15 months were randomly assigned to either anti-
Giardia and anthelminthic treatment, anti-
Giardia treatment only, or a control. Weight and supine length were recorded every 4 weeks. Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and
Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and
G. intestinalis cysts were determined. Data on 222 fully compliant infants were analysed. No significant differences in intestinal permeability, biochemical or anthropometric variables were found between the intervention groups, although there were associations between improvement in small intestinal mucosal function and better weight-for-age and weight-for-height (length)
Z-scores. GSIgM titres indicated high endemicity with rapid re-infection of
Giardia among infants; over 95% of infants were positive throughout the study, whereas the stool examination showed very few infants with either geohelminth eggs or
Giardia cysts (ClinicalTrials.gov Identifier:
NCT00607074).</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18789466</pmid><doi>10.1016/j.trstmh.2008.07.020</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0035-9203 |
| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 2009-05, Vol.103 (5), p.520-529 |
| issn | 0035-9203 1878-3503 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67124955 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Albendazole - therapeutic use Animals Anthelmintics - therapeutic use Anthropometry Antiprotozoal Agents - therapeutic use Bangladesh Biological and medical sciences Breast Feeding - statistics & numerical data Double-Blind Method Female General aspects Giardia intestinalis Giardiasis - complications Giardiasis - drug therapy Growth Growth Disorders - etiology Helminths Humans Infant Intestinal absorption Intestinal Mucosa - drug effects Intestinal Mucosa - parasitology Longitudinal Studies Male Malnutrition Medical sciences Metabolic diseases Metronidazole - analogs & derivatives Metronidazole - therapeutic use Mothers - education Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) |
| title | Impact of anti- Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T06%3A54%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20anti-%20Giardia%20and%20anthelminthic%20treatment%20on%20infant%20growth%20and%20intestinal%20permeability%20in%20rural%20Bangladesh:%20a%20randomised%20double-blind%20controlled%20study&rft.jtitle=Transactions%20of%20the%20Royal%20Society%20of%20Tropical%20Medicine%20and%20Hygiene&rft.au=Goto,%20Rie&rft.date=2009-05-01&rft.volume=103&rft.issue=5&rft.spage=520&rft.epage=529&rft.pages=520-529&rft.issn=0035-9203&rft.eissn=1878-3503&rft.coden=TRSTAZ&rft_id=info:doi/10.1016/j.trstmh.2008.07.020&rft_dat=%3Cproquest_cross%3E20189210%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20189210&rft_id=info:pmid/18789466&rft_oup_id=10.1016/j.trstmh.2008.07.020&rft_els_id=S0035920308003349&rfr_iscdi=true |