E3 ubiquitin ligases for MHC molecules

Recently, novel E3 ubiquitin ligases that target MHC molecules for lysosomal degradation have been discovered by several groups. All these E3s are membrane-bound and possess a variant type RING domain, termed the RING-CH or RING variant (RINGv) domain. They belong to a new E3 family designated Modul...

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Veröffentlicht in:	Current opinion in immunology 2009-02, Vol.21 (1), p.78-83
Hauptverfasser:	Ishido, Satoshi, Goto, Eiji, Matsuki, Yohei, Ohmura-Hoshino, Mari
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cytotoxicity, Immunologic Gene Expression Regulation - immunology Histocompatibility Antigens - genetics Histocompatibility Antigens - immunology Histocompatibility Antigens - metabolism Humans Immunity, Cellular Protein Transport RING Finger Domains - immunology Ubiquitin-Protein Ligases - immunology Ubiquitin-Protein Ligases - metabolism Ubiquitination - immunology Viral Proteins - immunology Viral Proteins - metabolism Virulence Virus Diseases - immunology Viruses - enzymology Viruses - immunology Viruses - pathogenicity
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