Vanillin Suppresses Metastatic Potential of Human Cancer Cells through PI3K Inhibition and Decreases Angiogenesis in Vivo
Vanillin, a food flavoring agent, has been shown to suppress cancer cell migration and metastasis in a mouse model, but its mechanism of action is unknown. In this report, we have examined the antimetastatic potential of vanillin and its structurally related compounds, vanillic acid, vanillyl alcoho...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2009-04, Vol.57 (8), p.3055-3063 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Lirdprapamongkol, Kriengsak Kramb, Jan-Peter Suthiphongchai, Tuangporn Surarit, Rudee Srisomsap, Chantragan Dannhardt, Gerd Svasti, Jisnuson |
| description | Vanillin, a food flavoring agent, has been shown to suppress cancer cell migration and metastasis in a mouse model, but its mechanism of action is unknown. In this report, we have examined the antimetastatic potential of vanillin and its structurally related compounds, vanillic acid, vanillyl alcohol, and apocynin on hepatocyte growth factor (HGF)-induced migration of human lung cancer cells by the Transwell assay. Vanillin and apocynin could inhibit cell migration, and both compounds selectively inhibited Akt phosphorylation of HGF signaling, without affecting phosphorylation of Met and Erk. Vanillin and apocynin could inhibit the enzymatic activity of phosphoinositide 3-kinase (PI3K), as revealed by an in vitro lipid kinase assay, suggesting that inhibition of PI3K activity was a mechanism underlying the inhibitory effect on cancer cell migration, and the presence of an aldehyde or ketone group in the vanillin structure was important for this inhibition. Vanillin and apocynin also inhibited angiogenesis, determined by the chick chorioallantoic membrane assay. |
| doi_str_mv | 10.1021/jf803366f |
| format | Article |
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In this report, we have examined the antimetastatic potential of vanillin and its structurally related compounds, vanillic acid, vanillyl alcohol, and apocynin on hepatocyte growth factor (HGF)-induced migration of human lung cancer cells by the Transwell assay. Vanillin and apocynin could inhibit cell migration, and both compounds selectively inhibited Akt phosphorylation of HGF signaling, without affecting phosphorylation of Met and Erk. Vanillin and apocynin could inhibit the enzymatic activity of phosphoinositide 3-kinase (PI3K), as revealed by an in vitro lipid kinase assay, suggesting that inhibition of PI3K activity was a mechanism underlying the inhibitory effect on cancer cell migration, and the presence of an aldehyde or ketone group in the vanillin structure was important for this inhibition. Vanillin and apocynin also inhibited angiogenesis, determined by the chick chorioallantoic membrane assay.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf803366f</identifier><identifier>PMID: 19368348</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Acetophenones - pharmacology ; Adenocarcinoma ; angiogenesis ; anticarcinogenic activity ; apocynin ; Benzaldehydes - pharmacology ; Bioactive Constituents ; Biological and medical sciences ; Cell Line, Tumor ; cell migration ; Cell Movement - drug effects ; enzyme inhibition ; Enzyme Inhibitors - pharmacology ; Food industries ; Fundamental and applied biological sciences. Psychology ; Hepatocyte Growth Factor - pharmacology ; human cell lines ; Humans ; kinases ; Lung Neoplasms ; Neoplasm Metastasis - prevention & control ; Neovascularization, Pathologic - prevention & control ; phenols ; Phosphatidylinositol 3-Kinases - antagonists & inhibitors ; phosphoinositide 3-kinase ; Signal Transduction - drug effects ; vanillin</subject><ispartof>Journal of agricultural and food chemistry, 2009-04, Vol.57 (8), p.3055-3063</ispartof><rights>Copyright © 2009 American Chemical Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a433t-46a7a2d6152d30f36af216de946b12fa8c80f7bf987519711bee1d7fd69c2dad3</citedby><cites>FETCH-LOGICAL-a433t-46a7a2d6152d30f36af216de946b12fa8c80f7bf987519711bee1d7fd69c2dad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf803366f$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf803366f$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21415305$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19368348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lirdprapamongkol, Kriengsak</creatorcontrib><creatorcontrib>Kramb, Jan-Peter</creatorcontrib><creatorcontrib>Suthiphongchai, Tuangporn</creatorcontrib><creatorcontrib>Surarit, Rudee</creatorcontrib><creatorcontrib>Srisomsap, Chantragan</creatorcontrib><creatorcontrib>Dannhardt, Gerd</creatorcontrib><creatorcontrib>Svasti, Jisnuson</creatorcontrib><title>Vanillin Suppresses Metastatic Potential of Human Cancer Cells through PI3K Inhibition and Decreases Angiogenesis in Vivo</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Vanillin, a food flavoring agent, has been shown to suppress cancer cell migration and metastasis in a mouse model, but its mechanism of action is unknown. In this report, we have examined the antimetastatic potential of vanillin and its structurally related compounds, vanillic acid, vanillyl alcohol, and apocynin on hepatocyte growth factor (HGF)-induced migration of human lung cancer cells by the Transwell assay. Vanillin and apocynin could inhibit cell migration, and both compounds selectively inhibited Akt phosphorylation of HGF signaling, without affecting phosphorylation of Met and Erk. Vanillin and apocynin could inhibit the enzymatic activity of phosphoinositide 3-kinase (PI3K), as revealed by an in vitro lipid kinase assay, suggesting that inhibition of PI3K activity was a mechanism underlying the inhibitory effect on cancer cell migration, and the presence of an aldehyde or ketone group in the vanillin structure was important for this inhibition. Vanillin and apocynin also inhibited angiogenesis, determined by the chick chorioallantoic membrane assay.</description><subject>Acetophenones - pharmacology</subject><subject>Adenocarcinoma</subject><subject>angiogenesis</subject><subject>anticarcinogenic activity</subject><subject>apocynin</subject><subject>Benzaldehydes - pharmacology</subject><subject>Bioactive Constituents</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>cell migration</subject><subject>Cell Movement - drug effects</subject><subject>enzyme inhibition</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepatocyte Growth Factor - pharmacology</subject><subject>human cell lines</subject><subject>Humans</subject><subject>kinases</subject><subject>Lung Neoplasms</subject><subject>Neoplasm Metastasis - prevention & control</subject><subject>Neovascularization, Pathologic - prevention & control</subject><subject>phenols</subject><subject>Phosphatidylinositol 3-Kinases - antagonists & inhibitors</subject><subject>phosphoinositide 3-kinase</subject><subject>Signal Transduction - drug effects</subject><subject>vanillin</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E9vFCEYBnBiNHZbPfgFlItNPIzywgzDHJv1TzfW2KS218k7DOyymYUtMCb99tLspr144sAvDw8PIe-AfQbG4cvWKiaElPYFWUDDWdUAqJdkwcplpRoJJ-Q0pS1jTDUte01OoBNSiVotyMMdejdNztObeb-PJiWT6C-TMWXMTtPrkI3PDicaLL2cd-jpEr02kS7NNCWaNzHM6w29XomfdOU3bnDZBU_Rj_Sr0dHgY-CFX7uwNt4kl2h56879DW_IK4tTMm-P5xm5_f7tz_Kyuvr9Y7W8uKqwFiJXtcQW-SjLv0bBrJBoOcjRdLUcgFtUWjHbDrZTbQNdCzAYA2NrR9lpPuIozsj5IXcfw_1sUu53LulSHr0Jc-plC1wwEAV-OkAdQ0rR2H4f3Q7jQw-sf9y5f9q52PfH0HnYmfFZHoct4OMRYNI42VhGc-nJcaihEawp7sPBWQw9rmMxtze81GEgOfCGPSehTv02zNGXtf5T6R_jE5sR</recordid><startdate>20090422</startdate><enddate>20090422</enddate><creator>Lirdprapamongkol, Kriengsak</creator><creator>Kramb, Jan-Peter</creator><creator>Suthiphongchai, Tuangporn</creator><creator>Surarit, Rudee</creator><creator>Srisomsap, Chantragan</creator><creator>Dannhardt, Gerd</creator><creator>Svasti, Jisnuson</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090422</creationdate><title>Vanillin Suppresses Metastatic Potential of Human Cancer Cells through PI3K Inhibition and Decreases Angiogenesis in Vivo</title><author>Lirdprapamongkol, Kriengsak ; Kramb, Jan-Peter ; Suthiphongchai, Tuangporn ; Surarit, Rudee ; Srisomsap, Chantragan ; Dannhardt, Gerd ; Svasti, Jisnuson</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a433t-46a7a2d6152d30f36af216de946b12fa8c80f7bf987519711bee1d7fd69c2dad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetophenones - pharmacology</topic><topic>Adenocarcinoma</topic><topic>angiogenesis</topic><topic>anticarcinogenic activity</topic><topic>apocynin</topic><topic>Benzaldehydes - pharmacology</topic><topic>Bioactive Constituents</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>cell migration</topic><topic>Cell Movement - drug effects</topic><topic>enzyme inhibition</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hepatocyte Growth Factor - pharmacology</topic><topic>human cell lines</topic><topic>Humans</topic><topic>kinases</topic><topic>Lung Neoplasms</topic><topic>Neoplasm Metastasis - prevention & control</topic><topic>Neovascularization, Pathologic - prevention & control</topic><topic>phenols</topic><topic>Phosphatidylinositol 3-Kinases - antagonists & inhibitors</topic><topic>phosphoinositide 3-kinase</topic><topic>Signal Transduction - drug effects</topic><topic>vanillin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lirdprapamongkol, Kriengsak</creatorcontrib><creatorcontrib>Kramb, Jan-Peter</creatorcontrib><creatorcontrib>Suthiphongchai, Tuangporn</creatorcontrib><creatorcontrib>Surarit, Rudee</creatorcontrib><creatorcontrib>Srisomsap, Chantragan</creatorcontrib><creatorcontrib>Dannhardt, Gerd</creatorcontrib><creatorcontrib>Svasti, Jisnuson</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lirdprapamongkol, Kriengsak</au><au>Kramb, Jan-Peter</au><au>Suthiphongchai, Tuangporn</au><au>Surarit, Rudee</au><au>Srisomsap, Chantragan</au><au>Dannhardt, Gerd</au><au>Svasti, Jisnuson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vanillin Suppresses Metastatic Potential of Human Cancer Cells through PI3K Inhibition and Decreases Angiogenesis in Vivo</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2009-04-22</date><risdate>2009</risdate><volume>57</volume><issue>8</issue><spage>3055</spage><epage>3063</epage><pages>3055-3063</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Vanillin, a food flavoring agent, has been shown to suppress cancer cell migration and metastasis in a mouse model, but its mechanism of action is unknown. In this report, we have examined the antimetastatic potential of vanillin and its structurally related compounds, vanillic acid, vanillyl alcohol, and apocynin on hepatocyte growth factor (HGF)-induced migration of human lung cancer cells by the Transwell assay. Vanillin and apocynin could inhibit cell migration, and both compounds selectively inhibited Akt phosphorylation of HGF signaling, without affecting phosphorylation of Met and Erk. Vanillin and apocynin could inhibit the enzymatic activity of phosphoinositide 3-kinase (PI3K), as revealed by an in vitro lipid kinase assay, suggesting that inhibition of PI3K activity was a mechanism underlying the inhibitory effect on cancer cell migration, and the presence of an aldehyde or ketone group in the vanillin structure was important for this inhibition. Vanillin and apocynin also inhibited angiogenesis, determined by the chick chorioallantoic membrane assay.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>19368348</pmid><doi>10.1021/jf803366f</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of agricultural and food chemistry, 2009-04, Vol.57 (8), p.3055-3063 |
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| language | eng |
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| subjects | Acetophenones - pharmacology Adenocarcinoma angiogenesis anticarcinogenic activity apocynin Benzaldehydes - pharmacology Bioactive Constituents Biological and medical sciences Cell Line, Tumor cell migration Cell Movement - drug effects enzyme inhibition Enzyme Inhibitors - pharmacology Food industries Fundamental and applied biological sciences. Psychology Hepatocyte Growth Factor - pharmacology human cell lines Humans kinases Lung Neoplasms Neoplasm Metastasis - prevention & control Neovascularization, Pathologic - prevention & control phenols Phosphatidylinositol 3-Kinases - antagonists & inhibitors phosphoinositide 3-kinase Signal Transduction - drug effects vanillin |
| title | Vanillin Suppresses Metastatic Potential of Human Cancer Cells through PI3K Inhibition and Decreases Angiogenesis in Vivo |
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