Dihydroquercetin (taxifolin) and other flavonoids as inhibitors of free radical formation at key stages of apoptosis

Formation of free radicals in mitochondria plays a key role in the development of apoptosis, which includes formation of superoxide by the respiratory chain, formation of radicals by cytochrome c-cardiolipin complex in the presence of hydrogen peroxide or lipids, and chain lipid peroxidation resulti...

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Veröffentlicht in:	Biochemistry (Moscow) 2009-03, Vol.74 (3), p.301-307
Hauptverfasser:	Vladimirov, Yu. A, Proskurnina, E. V, Demin, E. M, Matveeva, N. S, Lubitskiy, O. B, Novikov, A. A, Izmailov, D. Yu, Osipov, A. N, Tikhonov, V. P, Kagan, V. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Chemiluminescence Chromans - chemistry Chromans - pharmacology Cytochrome Cytochromes c - metabolism Dose-Response Relationship, Drug Flavonoids Flavonoids - chemistry Flavonoids - pharmacology Free radicals Free Radicals - antagonists & inhibitors Free Radicals - metabolism Hydrogen peroxide Life Sciences Lipids Liver - cytology Liver - drug effects Liver - metabolism Microbiology Mitochondrial DNA Molecular Structure Peroxidase - antagonists & inhibitors Peroxidase - metabolism Peroxidation Quercetin - analogs & derivatives Quercetin - chemistry Quercetin - pharmacology Rutin - chemistry Rutin - pharmacology Superoxides - antagonists & inhibitors Superoxides - metabolism
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