Three-dimensional high-resolution imaging of cardiac proteins to construct models of intracellular Ca2+ signalling in rat ventricular myocytes

Quantitative understanding of the Ca 2+ handling in cardiac ventricular myocytes requires accurate knowledge of cardiac ultrastructure and protein distribution. We have therefore developed high-resolution imaging and analysis approaches to measure the three-dimensional distribution of immunolabelled...

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Veröffentlicht in:	Experimental physiology 2009-05, Vol.94 (5), p.496-508
Hauptverfasser:	Soeller, Christian, Jayasinghe, Isuru D., Li, Pan, Holden, Arun V., Cannell, Mark B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Signaling Fluorescent Antibody Technique, Indirect Imaging, Three-Dimensional In Vitro Techniques Microscopy, Confocal Models, Cardiovascular Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Myofibrils - metabolism Myofibrils - ultrastructure Rats Rats, Wistar Ryanodine Receptor Calcium Release Channel - metabolism Stochastic Processes
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