Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

Common features such as elastic fibre destruction, mucoid accumulation, and smooth muscle cell apoptosis are co-localized in aneurysms of the ascending aorta of various aetiologies. Recent experimental studies reported an activation of TGF-β in aneurysms related to Marfan (and Loeys-Dietz) syndrome....

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Veröffentlicht in:	The Journal of pathology 2009-05, Vol.218 (1), p.131-142
Hauptverfasser:	Gomez, Delphine, Al Haj Zen, Ayman, Borges, Luciano F, Philippe, Monique, Gutierrez, Paulo Sampaio, Jondeau, Guillaume, Michel, Jean-Baptiste, Vranckx, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aorta - metabolism Aorta - pathology Aortic Aneurysm - complications Aortic Aneurysm - genetics Aortic Aneurysm - metabolism bicuspid aortic valves Biological and medical sciences Biomarkers - analysis Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Cell Differentiation decorin Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Gene Expression Humans Immunoblotting - methods Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Latent TGF-beta Binding Proteins - analysis Latent TGF-beta Binding Proteins - genetics LTBP-1 Marfan syndrome Marfan Syndrome - complications Marfan Syndrome - genetics Marfan Syndrome - metabolism Medical sciences Middle Aged Muscle, Smooth, Vascular - pathology PAI-1 Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques proteoglycans Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Signal Transduction - physiology Smad2 Protein - analysis Smad2 Protein - genetics Smad2 Protein - metabolism Statistics, Nonparametric TGF-β Transforming Growth Factor beta1 - analysis Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism
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